The FN3 and BRCT motifs in the exomer component Chs5p define a conserved module that is necessary and sufficient for its function

Chs5p is a component of the exomer, a coat complex required to transport the chitin synthase Chs3p from the trans-Golgi network to the plasma membrane. The Chs5p N-terminal region exhibits fibronectin type III (FN3) and BRCT domains. FN3 domains are present in proteins that mediate adhesion processes, whereas BRCT domains are involved in DNA repair. Several fungi—including Schizosaccharomyces pombe, which has no detectable amounts of chitin—have proteins similar to Chs5p. Here we show that the FN3 and BRCT motifs in Chs5p behave as a module that is necessary and sufficient for Chs5p localization and for cargo delivery. The N-terminal regions of S. cerevisiae Chs5p and S. pombe Cfr1p are interchangeable in terms of Golgi localization, but not in terms of exomer assembly, showing that the conserved function of this module is protein retention in this organelle and that the interaction between the exomer components is organism-specific.     

Aging behavior of a copper-bearing high-strength low-carbon steel

The effects of aging temperature and time on the hardness and impact toughness of a copper-bearing high-strength low-carbon steel were investigated. The hardness of the aged samples reached maxima after 1 h and 5 h of aging at 500 and 450℃, respectively; this increase in hardness was followed by a decrease in hardness until a temperature of 700℃, at which secondary hardening was observed. The impact toughness of the aged steel was found to be higher for 5 h of aging. Transmission electron microscopy confirmed the presence of carbide and copper precipitates; also, the secondary hardening could be the result of the transformation of austenite (formed in the aging treatment) to martensite. Differential scanning calorimetry of the steel was performed to better understand the precipitation behavior. The results revealed that the precipitation of the steel exhibited two significant stages of copper precipitate nucleation and coarsening of the precipitates, with corresponding activation energies of 49 and 238 kJ·mol-1, respectively.     

The Critical Heuristics of Iranian Banking Credit System: Analysis of the Antithetical Opinions of the Beneficiaries

Systemic Practice and Action Research - Considering the unfortunate intensification of the Non-performing loans in Iran`s credits system makes it vital to study the current system shortcomings....     

Combined Moho Parameters Determination Using CRUST1.0 and Vening Meinesz-Moritz Model

According to Vening Meinesz-Moritz (VMM) global inverse isostatic problem, either the Moho density contrast (crust-mantle density contrast) or the Moho geometry can be estimated by solv-ing a non-linea...     

Kinetics of magnetite oxidation under non-isothermal conditions

Oxidation of magnetite concentrates, which occurs during the pellet induration process, must be deeply understood to enable the appropriate design of induration machines. In the present paper, the kinetics of the magnetite oxidation reaction was studied. Primary samples were obtained from the Gol-e-Gohar iron ore deposit. Magnetic separation and flotation decreased the sulfur content in the samples to be approximately 0.1wt%. Thermogravimetric analysis was used to measure mass changes during the oxidation of magnetite and, consequently, the conversion values. The aim of this study was to use isoconversional methods to calculate the kinetic parameters. The Coats-Redfern method was also used to obtain the activation energy. Thermogravimetric analyses were run at three different heating rates. The Coats-Redfern results were too ambiguous for a meaningful interpretation. In the case of the isoconversional method, however, the mean activation energy and pre-exponential factor of the oxidation reaction were obtained as 67.55 kJ and 15.32×108 min-1, respectively. Such a large activation energy implies that temperature strongly affects the reaction rate. The oxidation reaction exhibits a true multi-step nature that is predominantly controlled by chemical reaction and diffusion mechanisms.     

Synthesis of WC powder through microwave heating of WO3-C mixture

A simple, easy, and low-cost process for the fabrication of tungsten carbide (WC) powder through microwave heating of WO₃-C mixtures was developed. Thermodynamic calculations and experimental investigations were carried out for WO₃-C and W-C systems, and a formation mechanism was proposed. In the results, for the synthesis of WC, the use of over stoichiometric amount of C together with a specially assembled experimental setup (which effectively retains heat in the system) is necessary. The WC powder is successfully obtained by heating WO₃:5C mixture for 900s in a domestic microwave oven.     

炭化对聚丙烯腈/酚醛基炭/炭复合材料结构和力学性能影响

由湿法叠涂制得的聚丙烯腈(PA N )/酚醛基碳/碳(C/C )复合材料在高性能结构材料领域具有应用潜力.为了了解炭化步骤对聚丙烯腈/酚醛基碳/碳复合材料结构和力学性能的影响 ,进行了层间断裂韧性(模式Ⅱ)测试.由于结构特征与裂纹形成机理的相互关系对C/C-SiC复合材料的制备很重要 ,采用阿基米德方法、扫描电子显微镜(SEM )和三点弯曲试验对复合材料的结构进行表征.实验结果显示 ,碳/碳(C/C)试件的层间断裂韧性为碳纤维增强酚醛塑料(CFRP)试件的59.7%.