川东高陡构造成因地质模式与含气性分析

川东高陡构造位于四川盆地东部 ,由一系列 NE-NNE向的隔档式褶皱组成。其构造变形经历了由隔槽式褶皱到“两背一断”,最终形成隔挡式褶皱的演化过程。在“两背一断”先存构造研究基础上 ,按继承发展的观点 ,综合运用伸展构造、反转构造、断层相关褶皱等构造新理论 ,系统探讨了川东高陡构造形成演化的成因地质模式 ,结合志留系主力生烃层的生气高峰期 ,对地腹不同成因类型的构造圈闭含气性进行了分析。     

求实与务实:高校学生思想政治工作新探

在高校学生思想政治工作中 ,求实与务实是引导大学生树立正确“三观”的基本方法 ,是高校实践“三个代表”的最佳切入点 ,也是解决大学生思想问题的有效途径     

Antibacterial agents based on the cyclic D,L-alpha-peptide architecture

The rapid emergence of bacterial infections that are resistant to many drugs underscores the need for new therapeutic agents. Here we report that six- and eight-residue cyclic d,l-alpha-peptides act preferentially on Gram-positive and/or Gram-negative bacterial membranes compared to mammalian cells, increase membrane permeability, collapse transmembrane ion potentials, and cause rapid cell death. The effectiveness of this class of materials as selective antibacterial agents is highlighted by the high efficacy observed against lethal methicillin-resistant Staphylococcus aureus infections in mice. Cyclic d,l-alpha-peptides are proteolytically stable, easy to synthesize, and can be derived from a potentially vast membrane-active sequence space. The unique abiotic structure of the cyclic peptides and their quick bactericidal action may also contribute to limit temporal acquirement of drug resistant bacteria. The low molecular weight d,l-alpha-peptides offer an attractive complement to the current arsenal of naturally derived antibiotics, and hold considerable potential in combating a variety of existing and emerging infectious diseases.     

基于PC架构Linux NAT性能优化

阐述了采用Netfilter/iptables技术来实现NAT的缘由 ,并分析了此项技术在Linux内核 2 .4中的一个重要新特性 ,即“连接跟踪” ;着重讨论了提高基于配有Linux操作系统的普通PC机上的NAT性能的方法 ,包括重编内核 ,防止空对话及修改tcp连接超时设定 ;通过一组系统状态监测曲线图证明这样一个廉价系统作为一些昂贵的路由设备的替代是稳定可靠的     

Expression of recombinant human lysozyme in the milk of transgenic mice

Human lysozyme is a 130-aa (amino acid) alkaline polypeptide, and has both anti-bacterial and anti-viral properties which make it an important component of human natural immunity system. As a first step toward the ultimate goal of improving the anti-bacterial properties of bovine and ovine milk, a transgenic mouse that contains the genomic DNA sequence of the human lysozme gene has been generated for the first time. From 83 mice generated by microinjection, a total of 6 positive transgenic mice were identified by PCR and Southern blot. F1 mice positive for transgene in lines were also detected by PCR. This shows that transgene could be transmitted from founder transgenic mice to their offspring. Recombinant human lysozyme (rHlys) was found in the whey of 3 female positive transgenic mice by Western blot. The highest concentration of rHlys for transgenic mice was 0.2mg/mL. The antibacterial activity of the whey for transgenic mice was highly enhanced up to 0.4 times as much as that of human, while that of non-transgenic mouse was very low. Although the lysozyme activity of transgenic mice is still lower than that of human, the rHlys exhibits the same specific activity as that of human lysozyme. It provides a strong basis for further studies into the possible application of rHlys express in mammary gland.     

Thermodynamic characterization of two novel spin-crossover complexes

Spin-crossover complexes are of great interest to the scientists because of their potential application in molecular-based electronic devices. Some octahedral metal compounds with 3dn (4 ≤ n ≤ 7) configuration can induce a spin state conversion through a fine tuning condition (temperature, pressure, light irradiation, etc.). If the conversion occurs reversibly with a hystersis loop and color change, it will make the system possessing memory effect. The memory effect can be magnified and the …     

Interleaving distribution of multifractal strength of 16-channel EEG signals

Muitifractai characteristics of 16-channel human electroencephalogram (EEG) signals under eye-closed rest are analyzed for the first time. The result shows that the EEGs from the different sites on the scalp have different muitifractai characteristics and the muitifractai strength value △α exhibits a kind of interleaving and left-right opposite distribution on scalp. This distribution rule is consistent with the localization of function and the iateralization theory in physiology. So △α can become an effective parameter to describe the brain potential character. And such a △α stable distribution rule on sites of the scalp means a classic cerebral cortex active state.     

Cardiac protective role of a novel erythrocyte-derived depressing factor on rats and its Ca^2＋ mechanism

The cardiac protective role of a novel erythro-cyte-derived depressing factor (EDDF) on spontaneous hy-pertensive rats (SHR), calcium overload (CaO) rats and Wistar rats and its mechanism was evaluated. Mean artery pressure (MAP), heart rate (HR) and LVdp/dtmax were measured by physiological recorder. The effect of EDDF on the Ca2+-ATPase activity in myocardial sarcoplasmic reticu-lum (SR) of CaO rats was determined by inorganic phos-phate assay. Calcium transport in myocytes was measured by 45Ca2+ radioactive isotope measurement. The phosphoryla-tion levels of extracellular signal-regulated protein kinases (ERK1/2) in myocardial tissue of SHR and CaO rats were measured by Western blot method. And the ultrastructures of cardiac muscle cells were observed with the transmission electron microscope. The results indicated that EDDF could significantly decrease MAP, HR and LVdp/dtmax in a dose dependent manner (P < 0.05). It seems that the mechanism might relate with activating the Ca2+-APTase, enhancing the uptake and release of Ca2+ from SR (P < 0.05), decreasing the phosphorylation levels of ERK1/2 of myocytes (P < 0.01) and lightening the ultrastructural lesion of cardiac muscle cells. In CaO rats, the Ca2+-ATPase activity decreased clearly com-pared to control (64.99 7.16 vs 94.48 7.68 nmol·min-1 ·mg-1 protein, P < 0.01), while EDDF (100 mg/mL) could significantly increase the activity (87.93 ?9.54 vs 64.99 ?7.16, P < 0.05, n = 7). Both uptake and release rate of Ca2+ (祄ol 45Ca2+/g protein/min) from myocardial SR of CaO rats re-markably decreased compared to control (32.40 ?2.70 and 15.46 ?1.49 vs 61.09 ?10.89 and 25.47 ?4.29, P < 0.05); EDDF (100 mg/mL) could significantly stimulate their activi-ties (50.48 6.76 and 21.76 2.75 vs 32.40 2.70 and 15.46 1.49, P < 0.05). EDDF could evidently down-regulate the phosphorylation of ERK1/2 in myocardial tissue from SHR and CaO rats (P < 0.01), lighten the ultrastructural lesion of cardiac muscle cells of SHR as well. It is concluded that EDDF seems to play protective roles on both structure and function of heart, which closely related with amelioration of Ca2+ transport and inhibition of Ca2+-MAP kinase pathway.     

诗骚性情漂泊魂－－杨骚心解

现代学史研究中有一种“寻找－转变－定格”的评价模式,以此来评价诗人杨骚多有失当。作为一位浪漫诗人,诗骚性情是进入其艺术世界的关键入口,贫病、多情、精神漂泊是他诗骚性情的一体三面。他的创作活动主要活跃于20－30年代,而他最好的诗作就在前期而不是在“转变”之后。即便是“转变”后的创作、爱情生活和社会政治活动也能够从其诗骚性情作由内而外的解释。     

《飞向宇宙》MCAI课件的制作

本文概要介绍《飞向宇宙》多媒体计算机辅助教学（MCAI）课件的制作过程,经了多媒体课件的通用制作方法,应用多媒体技术发展起来的多媒体CAI课件成为极具吸引力的现代化教学手段,它改变了传统的教育思想、教学模式,加速了教学现代化的进程。