论毛泽东的道德观及其时代价值

毛泽东道德观是马克思主义思想道德与中华民族传统伦理道德的有机结合.毛泽东道德观的主要内涵是以共产主义思想为指导、集体主义为基本原则,围绕为人民服务这一核心,以"五爱"为具体行为规范,以革命功利主义为评价标准,以做"五种人"为道德目标.毛泽东道德观是一本历久弥新的人生教科书,在今天仍有着其时代价值.     

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

The Abl kinase inhibitor imatinib mesylate is the preferred treatment for Philadelphia chromosome-positive (Ph(+)) chronic myeloid leukemia (CML) in chronic phase but is much less effective in CML blast crisis or Ph(+) B-cell acute lymphoblastic leukemia (B-ALL). Here, we show that Bcr-Abl activated the Src kinases Lyn, Hck and Fgr in B-lymphoid cells. BCR-ABL1 retrovirus-transduced marrow from mice lacking all three Src kinases efficiently induced CML but not B-ALL in recipients. The kinase inhibitor CGP76030 impaired the proliferation of B-lymphoid cells expressing Bcr-Abl in vitro and prolonged survival of mice with B-ALL but not CML. The combination of CGP76030 and imatinib was superior to imatinib alone in this regard. The biochemical target of CGP76030 in leukemia cells was Src kinases, not Bcr-Abl. These results implicate Src family kinases as therapeutic targets in Ph(+) B-ALL and suggest that simultaneous inhibition of Src and Bcr-Abl kinases may benefit individuals with Ph(+) acute leukemia.     

VEGF links hippocampal activity with neurogenesis, learning and memory

An enriched environment is associated with hippocampal plasticity, including improved cognitive performance and increased neurogenesis. Here, we show that hippocampal expression of vascular endothelial growth factor (VEGF) is increased by both an enriched environment and performance in a spatial maze. Hippocampal gene transfer of VEGF in adult rats resulted in approximately 2 times more neurogenesis associated with improved cognition. In contrast, overexpression of placental growth factor, which signals through Flt1 but not kinase insert domain protein receptors (KDRs), had negative effects on neurogenesis and inhibited learning, although it similarly increased endothelial cell proliferation. Expression of a dominant-negative mutant KDR inhibited basal neurogenesis and impaired learning. Coexpression of mutant KDR antagonized VEGF-enhanced neurogenesis and learning without inhibiting endothelial cell proliferation. Furthermore, inhibition of VEGF expression by RNA interference completely blocked the environmental induction of neurogenesis. These data support a model in which VEGF, acting through KDR, mediates the effect of the environment on neurogenesis and cognition.     

论知识经济时代下高职教育创新

该文论述了高职教育必须提高思想认识,构建合格的“双师型”教师队伍,改革教学方法手段和内容,实行开放式办学,转变教育体制,实现教育观念、师资队伍建设、教育体制、教学方法手段和内容以及办学方式的创新,以迎接知识经济的挑战,培养合格的创新型高职人才,保持高职教育自身得以生存与发展。     

Data fusion based on fuzzy measures

Choquet integral based on fuzzy measure is a very popular data fusion approach. A major problem in applying the Choquet integral is how to determine a large number of fuzzy measures as the number of attributes increases. The λ-fuzzy measure proposed by Sugeno is a powerful method to resolve this problem. However, the modeling ability of the λ-fuzzy measure is too limited to satisfy actual requirements. In this paper, an extended λ-fuzzy measure is proposed using Shapley value index, and the limitation of the λ-fuzzy measure is significantly overcome under little additional computational loads. The extended fuzzy measure has stronger modeling power than the λ-fuzzy measure, straightforwardly representing interaction among attributes. We apply the extended fuzzy measure to an artificial data set and a real dataset in an iron-steel plant. The results verify the usefulness of the extended fuzzy measure compared with other main existing methods.     

脚手架及模板支撑系统失稳问题分析

从脚手架及模板支撑系统的组成出发,分析了引起系统跨塌的各种原因,提出预防事故发生的相应措施。     

论钢琴演奏技巧和音乐的表现力

文章从以加强自己演奏技巧的训练和提高音乐表达能力及个人的音乐素养进行了论述。     

机械噪声的产生和控制

分析了机械噪声产生的原因,介绍了机械噪声的传播,阐述了控制机械噪声的一般原则与步骤。     

从哲学反思中探析马克思主义哲学教学创新

目前,我国高校的马克思主义哲学教学中存在着大学生学习积极性不高等问题。这些问题产生的根本原因不在于马克思主义哲学本身或其教学方法,而在于教学理念的失误。我们要改变马克思主义哲学的教学现状,就必须创新和重构一种与马克思主义哲学学科相适应的新的教学理念。