2-Carboxyethylgermanium sesquioxide,a synthetic organogermanium compound,as an inducer of contrasuppressor T cells

2-Carboxyethylgermanium sesquioxide (Ge-132), a synthesized organogermanium compound with immunomodulaing activities, was shown to be an inducer of anti-suppressor T cells in normal mice. The suppressor cell activity of T6S cells, a clone of burn-induced CD8⁺ IL-4-producing suppressor T cells, was clearly inhibited when a mixed lymphocyte-tumor cell reaction of the clone was conducted with splenic mononuclear cells from mice treated orally with a 100 mg/kg dose of Ge-132. The activity of anti-suppressor cells was demonstrated in spleens of mice 2 days after treatment with Ge-132 and reached its peak on day 3. The anti-suppressor cells induced by the compound were of a contrasuppressor T cell-linage, because they were characterized as CD4⁺ CD28⁺ TCR/⁺ Vicia villosa lectin-adherent T cells. These cells produced IFN- but did not produce IL-2, IL-4, IL-6 or IL-10 in their culture fluids. CD4⁺ anti-suppressor T cells induced by Ge-132 may be different from other subsets of CD4⁺ T cells because Th1 and Th2 cells generated in our laboratory did not adhere toVicia villosa lectin-coated petri dishes, and each produced specific cytokines. Th1 cells produced IFN- and IL-2 while Th2 cells produce IL-4 and IL-10 in vitro. These results suggest that Ge-132 may be useful as an inducer of contrasuppressor T cells in immunocompromised individuals bearing suppressor T cells. To eliminate suppressor T cells from immunocompromised hosts may result in improved resistance from various opportunistic infections.     

Cl−/HCO 3 − exchanger is operative in isolated enterocytes from rat jejunum

Enterocytes isolated from rat jejunum were tested for the existence of a Cl^–/HCO ₃ ^– exchange, previously evidenced in basolateral membrane vesicles but not in brush border. Cells were found to retain functional integrity and transport capabilities long enough to allow Cl^– fluxes to be measured. Both efflux and uptake experiments indicate that a Cl^–/HCO ₃ ^– antiport, inhibited by 4,4-diisothiocyanostilbene-2-2-disulfonic acid (DIDS), is functional under resting conditions.     

The use of cyclophosphamide as an enhancer of the vaccine against foot-and-mouth disease

The immunization of biungulate animals with killed foot-and-mouth disease virus (FMDV) requires periodic vaccinations due to a low vaccine immunogenicity. Therefore, FMDV antigens need to be combined with adjuvants such as aluminum hydroxide, saponin or oil emulsions. Animal handling for periodic inoculations, and the repeated doses of vaccines that have to be administered increase the commercialization costs. Moreover, the use of adjuvants may induce adverse effects.In the present work we show that it is possible to increase the life span of neutralizing antibodies in serum when a single dose of cyclophosphamide (Cy) is administered four days before vaccination with aluminum hydroxidesaponin FMDV vaccine.     

苏州大学教职工体育活动现状的调查与分析

本文以苏州大学教职工为研究对象,采用问卷与面访相结合的研究方法进行调查。结果发现,教职工对体育活动的爱好与实际参与存在较大差异,对实施全民健身计划认识不足,针对上述现状,提出今后在高校实施全民健身计划需待解决的若干问题。     

高炉异常炉况判断专家系统的设计与实现

探讨了高炉异常炉况判断专家系统的结构,讨论了从传感器数据中抽取高炉况特征的方法,时态黑板结构与时间知识表示,对于炉况特征的模糊量化和专家知识中的参数设定,系统采用机器学习方法自动调整,对于高炉异常炉况的操作方法,系统采用规划－动作－反应方法向用出动国作建议,并对所动作动作建议实现实时的重构解释。     

同时快速更换轧辊和导卫的高刚度机座

提出了一种可同时快速更换轧辊和导卫装置的高刚度轧机机座,适用于棒材、线材和型材轧制．该机座在机架上安装一个称为卡式箱的装置,卡式箱内可以预装轧辊和导卫,并在轧制线外调整好,可以实现轧辊和导卫一次吊装,快速更换．     

浅谈“无板起跳”训练法对提高业余跳远运动员助跑速度利用率的作用

在跳远技术教学训练中,阶段性采用取消跳板跳远的训练方法,消除运动员起跳前减速上板起跳的错误条件反射,提高速度利用率,从而最大限度地提高跳远成绩。     

一个课题的数据管理系统的设计

本文讨论了对“河西走廊荒漠绿洲交错区草地培育优化生态模式研究”课题中的数据建立数据管理系统的主要设计思想,并给出了该数据管理系统的主控模块程序清单。     

全国高研期刊论文数据库及其管理信息系统的研制

简要介绍了国家“八五”重点教育科研课题“建立中国教育文献数据库”的子课题“建立全国高教研究期刊及论文数据库”中对数据库及其管理系统软件的设计思想及其实现技术。     

系列硫氮环分子的量子化学从头算研究

本文用量子化学从头算方法对系列硫氮环分子的几何构型进行了全优化,得到了硫氮环分子基态的稳定构型,说明了各环型分子的成键情况。通过各硫氮环分子稳定性的比较,确定只有一部分硫氮环分子具有“多电子芳香性”。预测S_2N_3~+和S_5N_2~(2+)合成的可能性。