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81.
M E MacDonald A Novelletto C Lin D Tagle G Barnes G Bates S Taylor B Allitto M Altherr R Myers 《Nature genetics》1992,1(2):99-103
Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180. 相似文献
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Shape skeletonization (i.e., medial axis extraction) is powerful in many visual computing applications, such as pattern recognition, object segmentation, registration, and animation. In this paper, the authors expand the use of diffusion equations combined with distance field information to approximate medial axes of arbitrary 3D differential properties. It offers an alternative solids represented by polygonal meshes based on their but natural way for medial axis extraction for commonly used 3D polygonal models. By solving the PDE along time axis, this system can not only quickly extract diffusion-based medial axes of input meshes, but also allow users to visualize the extraction process at each time step. In addition, the proposed model provides users a set of manipulation toolkits to sculpt extracted medial axes, then use diffusion-based techniques to recover corresponding deformed shapes according to the original input datasets. This skeleton-based shape manipulation offers a fast and easy way for animation and deformation of complicated mesh objects. 相似文献
84.
Systemic Intervention in a University Department: Reflections on Arrested Action Research 总被引:1,自引:1,他引:0
Don Houston 《Systemic Practice and Action Research》2008,21(2):133-152
This paper reflects on my experience as an insider researcher attempting to use critical systems ideas and practices to promote
quality improvement in a university engineering department. Reflection is a key part of learning. This paper is intended to
contribute to critically, self-reflective learning for the community of systems practitioners. These reflections on my questions
about participation, ethics, politics of process, and the choices and actions resulting from them may help others to formulate
their own. The complexity of systems practice places substantial demands on the researcher, particularly in the case of insider,
practitioner research. Nevertheless, the exploration of critical systems approaches to critique boundaries and structure ‘problems’
in the core aspects of higher education in locally meaningful ways should continue. While demanding, it still can work to
promote learning about authentic quality. 相似文献
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A. Thienemann 《Cellular and molecular life sciences : CMLS》1948,4(10):411-411
Ohne Zusammenfassung 相似文献
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A. Policard 《Cellular and molecular life sciences : CMLS》1948,4(3):113-114
Summary By means of intratracheal injection, particles of metalloid silicium about five microns in size are introduced into the lungs of guinea pigs, and the secondary parenchymatous reactions are studied from 10 minutes to 105 days. In the dust cells, the silicium is progressively broken up into very small particles of less than 1 micron in size. The cells do not show degeneration or mummification as the ordinary silica cells (Mavrogordato) do. 相似文献
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