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961.
Einstein learned from the magnet and conductor thought experiment how to use field transformation laws to extend the covariance of Maxwells electrodynamics. If he persisted in his use of this device, he would have found that the theory cleaves into two Galilean covariant parts, each with different field transformation laws. The tension between the two parts reflects a failure not mentioned by Einstein: that the relativity of motion manifested by observables in the magnet and conductor thought experiment does not extend to all observables in electrodynamics. An examination of Ritzs work shows that Einsteins early view could not have coincided with Ritzs on an emission theory of light, but only with that of a conveniently reconstructed Ritz. One Ritz-like emission theory, attributed by Pauli to Ritz, proves to be a natural extension of the Galilean covariant part of Maxwells theory that happens also to accommodate the magnet and conductor thought experiment. Einsteins famous chasing a light beam thought experiment fails as an objection to an ether-based, electrodynamical theory of light. However it would allow Einstein to formulate his general objections to all emission theories of light in a very sharp form. Einstein found two well known experimental results of 18th and 19th century optics compelling (Fizeaus experiment, stellar aberration), while the accomplished Michelson-Morley experiment played no memorable role. I suggest they owe their importance to their providing a direct experimental grounding for Lorentz local time, the precursor of Einsteins relativity of simultaneity, and doing it essentially independently of electrodynamical theory. I attribute Einsteins success to his determination to implement a principle of relativity in electrodynamics, but I urge that we not invest this stubbornness with any mystical prescience.I am grateful to Diana Buchwald, Olivier Darrigol, Allen Janis, Michel Janssen, Robert Rynasiewicz and John Stachel for helpful discussion and for assistance in accessing source materials. 相似文献
962.
963.
Cichon S Buervenich S Kirov G Akula N Dimitrova A Green E Schumacher J Klopp N Becker T Ohlraun S Schulze TG Tullius M Gross MM Jones L Krastev S Nikolov I Hamshere M Jones I Czerski PM Leszczynska-Rodziewicz A Kapelski P Bogaert AV Illig T Hauser J Maier W Berrettini W Byerley W Coryell W Gershon ES Kelsoe JR McInnis MG Murphy DL Nurnberger JI Reich T Scheftner W O'Donovan MC Propping P Owen MJ Rietschel M Nöthen MM McMahon FJ Craddock N 《Nature genetics》2004,36(8):783-4; author reply 784-5
964.
McClelland M Sanderson KE Clifton SW Latreille P Porwollik S Sabo A Meyer R Bieri T Ozersky P McLellan M Harkins CR Wang C Nguyen C Berghoff A Elliott G Kohlberg S Strong C Du F Carter J Kremizki C Layman D Leonard S Sun H Fulton L Nash W Miner T Minx P Delehaunty K Fronick C Magrini V Nhan M Warren W Florea L Spieth J Wilson RK 《Nature genetics》2004,36(12):1268-1274
Salmonella enterica serovars often have a broad host range, and some cause both gastrointestinal and systemic disease. But the serovars Paratyphi A and Typhi are restricted to humans and cause only systemic disease. It has been estimated that Typhi arose in the last few thousand years. The sequence and microarray analysis of the Paratyphi A genome indicates that it is similar to the Typhi genome but suggests that it has a more recent evolutionary origin. Both genomes have independently accumulated many pseudogenes among their approximately 4,400 protein coding sequences: 173 in Paratyphi A and approximately 210 in Typhi. The recent convergence of these two similar genomes on a similar phenotype is subtly reflected in their genotypes: only 30 genes are degraded in both serovars. Nevertheless, these 30 genes include three known to be important in gastroenteritis, which does not occur in these serovars, and four for Salmonella-translocated effectors, which are normally secreted into host cells to subvert host functions. Loss of function also occurs by mutation in different genes in the same pathway (e.g., in chemotaxis and in the production of fimbriae). 相似文献
965.
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer 总被引:7,自引:0,他引:7
Huusko P Ponciano-Jackson D Wolf M Kiefer JA Azorsa DO Tuzmen S Weaver D Robbins C Moses T Allinen M Hautaniemi S Chen Y Elkahloun A Basik M Bova GS Bubendorf L Lugli A Sauter G Schleutker J Ozcelik H Elowe S Pawson T Trent JM Carpten JD Kallioniemi OP Mousses S 《Nature genetics》2004,36(9):979-983
The identification of tumor-suppressor genes in solid tumors by classical cancer genetics methods is difficult and slow. We combined nonsense-mediated RNA decay microarrays and array-based comparative genomic hybridization for the genome-wide identification of genes with biallelic inactivation involving nonsense mutations and loss of the wild-type allele. This approach enabled us to identify previously unknown mutations in the receptor tyrosine kinase gene EPHB2. The DU 145 prostate cancer cell line, originating from a brain metastasis, carries a truncating mutation of EPHB2 and a deletion of the remaining allele. Additional frameshift, splice site, missense and nonsense mutations are present in clinical prostate cancer samples. Transfection of DU 145 cells, which lack functional EphB2, with wild-type EPHB2 suppresses clonogenic growth. Taken together with studies indicating that EphB2 may have an essential role in cell migration and maintenance of normal tissue architecture, our findings suggest that mutational inactivation of EPHB2 may be important in the progression and metastasis of prostate cancer. 相似文献
966.
Janecke AR Thompson DA Utermann G Becker C Hübner CA Schmid E McHenry CL Nair AR Rüschendorf F Heckenlively J Wissinger B Nürnberg P Gal A 《Nature genetics》2004,36(8):850-854
We identified three consanguineous Austrian kindreds with 15 members affected by autosomal recessive childhood-onset severe retinal dystrophy, a genetically heterogeneous group of disorders characterized by degeneration of the photoreceptor cells. A whole-genome scan by microarray analysis of single-nucleotide polymorphisms (ref. 2) identified a founder haplotype and defined a critical interval of 1.53 cM on chromosome 14q23.3-q24.1 that contains the gene associated with this form of retinal dystrophy. RDH12 maps in this region and encodes a retinol dehydrogenase proposed to function in the visual cycle. A homozygous 677A-->G transition (resulting in Y226C) in RDH12 was present in all affected family members studied, as well as in two Austrian individuals with sporadic retinal dystrophy. We identified additional mutations in RDH12 in 3 of 89 non-Austrian individuals with retinal dystrophy: a 5-nucleotide deletion (806delCCCTG) and the transition 565C-->T (resulting in Q189X), each in the homozygous state, and 146C-->T (resulting in T49M) and 184C-->T (resulting in R62X) in compound heterozygosity. When expressed in COS-7 cells, Cys226 and Met49 variants had diminished and aberrant activity, respectively, in interconverting isomers of retinol and retinal. The severe visual impairment of individuals with mutations in RDH12 is in marked contrast to the mild visual deficiency in individuals with fundus albipunctatus caused by mutations in RDH5, encoding another retinal dehydrogenase. Our studies show that RDH12 is associated with retinal dystrophy and encodes an enzyme with a unique, nonredundant role in the photoreceptor cells. 相似文献
967.
Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19 总被引:7,自引:0,他引:7
Seow HF Bröer S Bröer A Bailey CG Potter SJ Cavanaugh JA Rasko JE 《Nature genetics》2004,36(9):1003-1007
Hartnup disorder (OMIM 234500) is an autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. We localized a gene causing Hartnup disorder to chromosome 5p15.33 and cloned a new gene, SLC6A19, in this region. SLC6A19 is a sodium-dependent and chloride-independent neutral amino acid transporter, expressed predominately in kidney and intestine, with properties of system B(0). We identified six mutations in SLC6A19 that cosegregated with disease in the predicted recessive manner, with most affected individuals being compound heterozygotes. The disease-causing mutations that we tested reduced neutral amino acid transport function in vitro. Population frequencies for the most common mutated SLC6A19 alleles are 0.007 for 517G --> A and 0.001 for 718C --> T. Our findings indicate that SLC6A19 is the long-sought gene that is mutated in Hartnup disorder; its identification provides the opportunity to examine the inconsistent multisystemic features of this disorder. 相似文献
968.
969.
Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment 总被引:2,自引:0,他引:2
Moran MA Buchan A González JM Heidelberg JF Whitman WB Kiene RP Henriksen JR King GM Belas R Fuqua C Brinkac L Lewis M Johri S Weaver B Pai G Eisen JA Rahe E Sheldon WM Ye W Miller TR Carlton J Rasko DA Paulsen IT Ren Q Daugherty SC Deboy RT Dodson RJ Durkin AS Madupu R Nelson WC Sullivan SA Rosovitz MJ Haft DH Selengut J Ward N 《Nature》2004,432(7019):910-913
Since the recognition of prokaryotes as essential components of the oceanic food web, bacterioplankton have been acknowledged as catalysts of most major biogeochemical processes in the sea. Studying heterotrophic bacterioplankton has been challenging, however, as most major clades have never been cultured or have only been grown to low densities in sea water. Here we describe the genome sequence of Silicibacter pomeroyi, a member of the marine Roseobacter clade (Fig. 1), the relatives of which comprise approximately 10-20% of coastal and oceanic mixed-layer bacterioplankton. This first genome sequence from any major heterotrophic clade consists of a chromosome (4,109,442 base pairs) and megaplasmid (491,611 base pairs). Genome analysis indicates that this organism relies upon a lithoheterotrophic strategy that uses inorganic compounds (carbon monoxide and sulphide) to supplement heterotrophy. Silicibacter pomeroyi also has genes advantageous for associations with plankton and suspended particles, including genes for uptake of algal-derived compounds, use of metabolites from reducing microzones, rapid growth and cell-density-dependent regulation. This bacterium has a physiology distinct from that of marine oligotrophs, adding a new strategy to the recognized repertoire for coping with a nutrient-poor ocean. 相似文献
970.
Migratory birds are known to use the geomagnetic field as a source of compass information. There are two competing hypotheses for the primary process underlying the avian magnetic compass, one involving magnetite, the other a magnetically sensitive chemical reaction. Here we show that oscillating magnetic fields disrupt the magnetic orientation behaviour of migratory birds. Robins were disoriented when exposed to a vertically aligned broadband (0.1-10 MHz) or a single-frequency (7-MHz) field in addition to the geomagnetic field. Moreover, in the 7-MHz oscillating field, this effect depended on the angle between the oscillating and the geomagnetic fields. The birds exhibited seasonally appropriate migratory orientation when the oscillating field was parallel to the geomagnetic field, but were disoriented when it was presented at a 24 degrees or 48 degrees angle. These results are consistent with a resonance effect on singlet-triplet transitions and suggest a magnetic compass based on a radical-pair mechanism. 相似文献