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991.
Salamah M. Alwahsh Hassan Rashidi David C. Hay 《Cellular and molecular life sciences : CMLS》2018,75(8):1307-1324
The prevalence of liver diseases is increasing globally. Orthotopic liver transplantation is widely used to treat liver disease upon organ failure. The complexity of this procedure and finite numbers of healthy organ donors have prompted research into alternative therapeutic options to treat liver disease. This includes the transplantation of liver cells to promote regeneration. While successful, the routine supply of good quality human liver cells is limited. Therefore, renewable and scalable sources of these cells are sought. Liver progenitor and pluripotent stem cells offer potential cell sources that could be used clinically. This review discusses recent approaches in liver cell transplantation and requirements to improve the process, with the ultimate goal being efficient organ regeneration. We also discuss the potential off-target effects of cell-based therapies, and the advantages and drawbacks of current pre-clinical animal models used to study organ senescence, repopulation and regeneration. 相似文献
992.
A C-Mn dual-phase steel was soaked at 800℃ for 90 s and then either rapidly cooled to 450℃ and held for 30 s (process A) or rapidly cooled to 350℃ and then reheated to 450℃ (process B) to simulate the hot-dip galvanizing process. The influence of the hot-dip galvanizing process on the microstructure and mechanical properties of 600-MPa hot-dip galvanized dual-phase steel (DP600) was investigated using optical microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and tensile tests. The results showed that, in the case of process A, the microstructure of DP600 was composed of ferrite, martensite, and a small amount of bainite. The granular bainite was formed in the hot-dip galvanizing stage, and martensite islands were formed in the final cooling stage after hot-dip galvanizing. By contrast, in the case of process B, the microstructure of the DP600 was composed of ferrite, martensite, bainite, and cementite. In addition, compared with the yield strength (YS) of the DP600 annealed by process A, that for the DP600 annealed by process B increased by approximately 50 MPa because of the tempering of the martensite formed during rapid cooling. The work-hardening coefficient (n value) of the DP600 steel annealed by process B clearly decreased because the increase of the YS affected the computation result for the n value. However, the ultimate tensile strength (UTS) and elongation (A80) of the DP600 annealed by process B exhibited less variation compared with those of the DP600 annealed by process A. Therefore, DP600 with excellent comprehensive mechanical properties (YS=362 MPa, UTS=638 MPa, A80=24.3%, n=0.17) was obtained via process A. 相似文献
993.
以深黄被孢霉为出发菌 ,通过硫酸二乙酯 (DES)诱变 ,获得优化的变异菌株 XM-1 .经初筛、复筛及传代实验 ,表明其是稳定的变异株 .变异株 XM-1在 2 8℃下 ,发酵 1 2 0 h后 ,菌体生物量为 1 5 .1 g/L ,油脂量为 7.5 g/L .与原始菌相比 ,生物量、油脂量分别提高了43.8%和 47% . 相似文献
994.
Diego Reginensi Patricia Carulla Sara Nocentini Oscar Seira Abel Torres-Espín Andreu Matamoros-Angles Rosalina Gavín María Teresa Moreno-Flores Francisco Wandosell Josep Samitier Xavier Trepat Xavier Navarro José Antonio del Río 《Cellular and molecular life sciences : CMLS》2015,72(14):2719-2737
Olfactory ensheathing cell (OEC) transplantation emerged some years ago as a promising therapeutic strategy to repair injured spinal cord. However, inhibitory molecules are present for long periods of time in lesioned spinal cord, inhibiting both OEC migration and axonal regrowth. Two families of these molecules, chondroitin sulphate proteoglycans (CSPG) and myelin-derived inhibitors (MAIs), are able to trigger inhibitory responses in lesioned axons. Mounting evidence suggests that OEC migration is inhibited by myelin. Here we demonstrate that OEC migration is largely inhibited by CSPGs and that inhibition can be overcome by the bacterial enzyme Chondroitinase ABC. In parallel, we have generated a stable OEC cell line overexpressing the Nogo receptor (NgR) ectodomain to reduce MAI-associated inhibition in vitro and in vivo. Results indicate that engineered cells migrate longer distances than unmodified OECs over myelin or oligodendrocyte-myelin glycoprotein (OMgp)-coated substrates. In addition, they also show improved migration in lesioned spinal cord. Our results provide new insights toward the improvement of the mechanisms of action and optimization of OEC-based cell therapy for spinal cord lesion. 相似文献
995.
Ping Song Tharmarajan Ramprasath Huan Wang Ming-Hui Zou 《Cellular and molecular life sciences : CMLS》2017,74(16):2899-2916
Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn), kynurenic acid (KA), 3-hydroxykynurenine (3-HK), xanthurenic acid (XA), and 3-hydroxyanthranilic acid (3-HAA). Increased catabolite concentrations in serum are associated with several cardiovascular diseases (CVD), including heart disease, atherosclerosis, and endothelial dysfunction, as well as their risk factors, including hypertension, diabetes, obesity, and aging. The first catabolic step in KP is primarily controlled by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO). Following this first step, the KP has two major branches, one branch is mediated by kynurenine 3-monooxygenase (KMO) and kynureninase (KYNU) and is responsible for the formation of 3-HK, 3-HAA, and quinolinic acid (QA); and another branch is controlled by kynurenine amino-transferase (KAT), which generates KA. Uncontrolled Trp catabolism has been demonstrated in distinct CVD, thus, understanding the underlying mechanisms by which regulates KP enzyme expression and activity is paramount. This review highlights the recent advances on the effect of KP enzyme expression and activity in different tissues on the pathological mechanisms of specific CVD, KP is an inflammatory sensor and modulator in the cardiovascular system, and KP catabolites act as the potential biomarkers for CVD initiation and progression. Moreover, the biochemical features of critical KP enzymes and principles of enzyme inhibitor development are briefly summarized, as well as the therapeutic potential of KP enzyme inhibitors against CVD is briefly discussed. 相似文献
996.
We investigate the energy nonadditivity relationship E(AαB) = E(A) + E(B) + αE(A)E(B) which is often considered in the development of the statistical physics of nonextensive systems. It was recently found that α in this equation was not constant for a given system in a given situation and could not characterize nonextensivity for that system. In this work, we select several typical nonextensive systems and compute the behavior of α when a system changes its size or is divided into subsystems in different fashions. Three kinds of interactions are considered. It is found by a thought experiment that α depends on the system size and the interaction as expected and on the way we divide the system. However, one of the major results of this work is that, for given system, α has a minimum with respect to division position. Around this position, there is a zone in which α is more or less constant, a situation where the sizes of the subsystems are comparable. The width of this zone depends on the interaction and on the system size. We conclude that if α is considered approximately constant in this zone, the two mathematical difficulties raised in previous studies are solved, meaning that the nonadditive relationship can characterize the nonadditivity of the system as an approximation. In all the cases, α tends to zero in the thermodynamic limit (N→∞) as expected. 相似文献
997.
LI JinHua PAN YongXin LIU QingSong QIN HuaFeng DENG ChengLong CHE RenChao & YANG XinAnKey Laboratory of the Earth’s Deep Interior Institute of Geology Geophysics Chinese Academy of Sciences Beijing China Graduate University of Chinese Academy of Sciences Beijing Franco-Chinese Biomineralization Nano-structures Laboratory State Key Laboratory of Lithospheric Evolution Chinese Academy of S... 《科学通报(英文版)》2010,55(1):38-44
The magnetic properties of magnetosome magnetite are of interdisciplinary interest because magnetosomes are potential carriers of natural remanent magnetization and paleoenvironment, as well as novel nano-biomaterials in biotechnological and biomedical applications. We carried out magnetic and electron transmission microscopy analyses of fresh Magnetospirillum magneticum AMB-1 whole cells and isolated magnetosomes. Results revealed that AMB-1 synthesized single-domain magnetite magneto-somes, which are arra... 相似文献
998.
朱墨 《首都师范大学学报(自然科学版)》2005,26(2):63-68
综述了寻找孢子体自交不亲和雌雄S决定子的过程,以及孢子体自交不亲和中的显隐性关系及其分类,并提出将来自交不亲和研究的方向。 相似文献
999.
Thomas L. SAATY 《系统科学与系统工程学报(英文版)》2004,13(4):385-404
1. Introduction This is the fourth exposition on theAnalytic Hierarchy Process. It is true thatmany decisions we make subconsciously ariseout of our physical and biological needs andderive from the pressure to survive physically.We also make subconsciou… 相似文献
1000.
Jingyuan YU Xiaoji ZHOU Shan FENG Beijing Institute of Information Control P.O. Box Beijing Chian Huazhong University of Science Technology 《系统科学与系统工程学报(英文版)》2005,14(4):462-475
1 Introduction Science of complexity and complex systems is a relatively new area In wide fields from chemistry, biology, environment, geo-science, climatology to economics and sociology, complexity has been studied from diverse views and understandings Systems science, which could be traced back to Ludwig von Bertalanffy’foundational work on general system theory, plays an active role in complexity studies From system perspectives, relevant concepts often include interaction, feedback, evol… 相似文献