工业机器人的多微机自适应控制算法

本文应用参数辨识和动态递阶控制方法研究工业机器人轨迹控制问题,提出了一种采用多微机系统的自适应控制算法,其在线执行时间短,便于实现。计算机仿真结果表明,本算法其有良好的控制效果。     

世界文化遗产利益相关者管理的理想模式研究--以布达拉宫为例

文章从利益相关者理论出发,构建了布达拉宫利益相关者管理的理想模式。作者把布达拉宫的利益相关者划分为决定性的利益相关者、可依靠的利益相关者和引起危险的利益相关者,针对不同的利益相关者,提出了具体管理内容和评价指标。     

超细Co-γ-Fe_2O_3磁粉的研制

应用TEM、XPS、XRD等分析技术,研究了包钴过程中各种因素对钴改性γ-Fe_2O_3磁粉的微观结构以及磁性能的影响。结果表明,钴铁氧体的形成是Co-γ-Fe_2O_3磁粉磁性能提高的主要原因。包少量钴(钴含量<1%),可使原磁粉的矫顽力提高约6.37kA/m。     

半经验分子轨道理论中Slater轨道指数对分子性质的一些影响

半经验分子轨道理论中 Slater 轨道指数§可表示成原子静电荷 q 的函数。本文按这种方法讨论了§随 q 的这种变化对分子性质的一些影响。     

维修“天窗”对电气化重载专线输送能力的影响

采用运行图模拟和理论分析相结合的方法,论证了电气化重载专线维修“天窗”的预留方式,并分析了各种“天窗”的预留方案对输送能力的影响.     

Green核积分方程迭代配置解的误差展开

本文讨论了Ｇｒｅｅｎ核积分方程的迭代配置方法，得到了迭代配置解的一个多项误差展开式。     

菲涅耳半波带法公式A_K=a_1/2±a_k/2中K值的范围

本文对在点光源照明情况下,用菲涅耳半波带法求考察点P合振幅的近似公式A_k=a_1/2±a_k/2中K值的适用范围进行了讨论,纠正了某些光学书籍中对K值范围加以限制的结论     

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

The Abl kinase inhibitor imatinib mesylate is the preferred treatment for Philadelphia chromosome-positive (Ph(+)) chronic myeloid leukemia (CML) in chronic phase but is much less effective in CML blast crisis or Ph(+) B-cell acute lymphoblastic leukemia (B-ALL). Here, we show that Bcr-Abl activated the Src kinases Lyn, Hck and Fgr in B-lymphoid cells. BCR-ABL1 retrovirus-transduced marrow from mice lacking all three Src kinases efficiently induced CML but not B-ALL in recipients. The kinase inhibitor CGP76030 impaired the proliferation of B-lymphoid cells expressing Bcr-Abl in vitro and prolonged survival of mice with B-ALL but not CML. The combination of CGP76030 and imatinib was superior to imatinib alone in this regard. The biochemical target of CGP76030 in leukemia cells was Src kinases, not Bcr-Abl. These results implicate Src family kinases as therapeutic targets in Ph(+) B-ALL and suggest that simultaneous inhibition of Src and Bcr-Abl kinases may benefit individuals with Ph(+) acute leukemia.     

Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia

Cleft lip, with or without cleft palate (CL/P), is one of the most common birth defects, occurring in 0.4 to 2.0 per 1,000 infants born alive. Approximately 70% of CL/P cases are non-syndromic (MIM 119530), but CL/P also occurs in many single-gene syndromes, each affecting a protein critical for orofacial development. Here we describe positional cloning of the gene responsible for an autosomal recessive CL/P-ectodermal dysplasia (ED) syndrome (CLPED1; previously ED4; ref. 2), which we identify as PVRL1, encoding nectin-1, an immunoglobulin (Ig)-related transmembrane cell-cell adhesion molecule that is part of the NAP cell adhesion system. Nectin-1 is also the principal cell surface receptor for alpha-herpesviruses (HveC; ref. 7), and the high frequency of CLPED1 on Margarita Island in the Caribbean Sea might result from resistance of heterozygotes to infection by these viruses.