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11.
Danielle Kamato Muhamad Ashraf Rostam Rebekah Bernard Terrence J. Piva Nitin Mantri Daniel Guidone Wenhua Zheng Narin Osman Peter J. Little 《Cellular and molecular life sciences : CMLS》2015,72(4):799-808
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. 相似文献
12.
林红喜 《江西科技师范学院学报》2003,(6):27-28,74
本文探讨了数控技术专业毕业综合实训的改革思路,提出按职业资格标准强化技能培训,使学生在毕业前获得数控机床操作职业资格证书,切实提高学生的职业素质与就业竞争能力。 相似文献
13.
LuJian-ke 《武汉大学学报:自然科学英文版》2004,9(1):1-5
The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. 相似文献
14.
Abrupt climate change:Debate or action 总被引:4,自引:1,他引:3
CHENGHai 《科学通报(英文版)》2004,49(18):1997-2002
Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere. 相似文献
15.
RAOLan-lan CAIDong-han 《武汉大学学报:自然科学英文版》2004,9(4):404-406
We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small. 相似文献
16.
李同军 《哈尔滨商业大学学报(自然科学版)》2003,19(3):326-328
给出用指形砂轮磨制螺旋插齿刀的通用CAD/CAM数学模型 ,并结合具体算例验证了方法及模型的可靠性 相似文献
17.
卢彤 《科技情报开发与经济》2004,14(12):234-235
通过对滹沱河河道电磁波三角高程测量中K值(大气折光系数)变化的分析,总结出该地区K值的变化规律,并提出三角高程测量中应注意的问题。 相似文献
18.
酸性硅溶胶沉淀法制备超微细活性白炭黑 总被引:2,自引:0,他引:2
对酸性硅溶胶沉淀法生产超微细活性白炭黑的工艺进行了研究;探讨了生产过程中硅溶胶的pH值,反应终点pH值,反应温度以及分散剂等条件;制备了较高品质的产品,其性能接近或超过国外同类产品. 相似文献
19.
童永承 《湖北师范学院学报(自然科学版)》1992,(6)
计数器电路的分析讨论相当费时和麻烦。本文提出了一个分析此一问题的一般方法,总结且证明了同步2~N—m 进计数器定理。在此基础上构成了一系列各类计数器,使分析讨论简单明了。 相似文献
20.
Static extracting method of software intended behavior based on API functions invoking 总被引:1,自引:0,他引:1
The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior's dynamic and trusted authentication. In this paper, the author proposes a specified measure of extracting SIBDS (software intended behaviors describing sets) statically from the binary executable using the software's API functions invoking, and also introduces the definition of the structure used to store the SIBDS in detail. Experimental results demonstrate that the extracting method and the storage structure definition offers three strong properties: (i) it can describe the software's intended behavior accurately; (ii) it demands a small storage expense; (iii) it provides strong capability to defend against mimicry attack. 相似文献