Evolution and stability of holographic soliton pairs

Previous works concerning the generation of spatial optical solitons using interference pattern[1―5] can be divided into two categories: First, the interference of two beams was used to generate a periodic spatial pat-tern and then the pattern is injecte…     

Limited number of patrilines in horse domestication

Genetic studies using mitochondrial DNA (mtDNA) have identified extensive matrilinear diversity among domestic horses. Here, we show that this high degree of polymorphism is not matched by a corresponding patrilinear diversity of the male-specific Y chromosome. In fact, a screening for single-nucleotide polymorphisms (SNPs) in 14.3 kb of noncoding Y chromosome sequence among 52 male horses of 15 different breeds did not identify a single segregation site. These observations are consistent with a strong sex-bias in the domestication process, with few stallions contributing genetically to the domestic horse.     

Hox cluster disintegration with persistent anteroposterior order of expression in Oikopleura dioica

Tunicate embryos and larvae have small cell numbers and simple anatomical features in comparison with other chordates, including vertebrates. Although they branch near the base of chordate phylogenetic trees, their degree of divergence from the common chordate ancestor remains difficult to evaluate. Here we show that the tunicate Oikopleura dioica has a complement of nine Hox genes in which all central genes are lacking but a full vertebrate-like set of posterior genes is present. In contrast to all bilaterians studied so far, Hox genes are not clustered in the Oikopleura genome. Their expression occurs mostly in the tail, with some tissue preference, and a strong partition of expression domains in the nerve cord, in the notochord and in the muscle. In each tissue of the tail, the anteroposterior order of Hox gene expression evokes spatial collinearity, with several alterations. We propose a relationship between the Hox cluster breakdown, the separation of Hox expression domains, and a transition to a determinative mode of development.     

A Bayesian analysis of periodic integration

Recent empirical research into the seasonal and trend properties of macroeconomic time series using periodic models has resulted in strong evidence in favour of periodic integration (PI). PI implies that the differencing filter necessary to remove a stochastic trend varies across seasons and, hence, that seasonal fluctuations are related to the stochastic trend. Previous studies finding evidence of PI have used classical econometric techniques. In this paper, we investigate the possible sensitivity of this empirical result by using Bayesian techniques. An application of posterior odds analysis and highest posterior density interval tests to several quarterly UK macroeconomic series suggests strong evidence for PI, even when we allow for structural breaks in the deterministic seasonals. A predictive exercise indicates that PI usually outperforms other competing models in terms of out-of-sample forecasting. © 1997 John Wiley & Sons, Ltd.     

Forecasting stock market volatility using (non-linear) Garch models

In this paper we study the performance of the GARCH model and two of its non-linear modifications to forecast weekly stock market volatility. The models are the Quadratic GARCH (Engle and Ng, 1993) and the Glosten, Jagannathan and Runkle (1992) models which have been proposed to describe, for example, the often observed negative skewness in stock market indices. We find that the QGARCH model is best when the estimation sample does not contain extreme observations such as the 1987 stock market crash and that the GJR model cannot be recommended for forecasting.     

Model‐based forecast adjustment: With an illustration to inflation

This paper introduces the idea of adjusting forecasts from a linear time series model where the adjustment relies on the assumption that this linear model is an approximation of a nonlinear time series model. This way of creating forecasts could be convenient when inference for a nonlinear model is impossible, complicated or unreliable in small samples. The size of the forecast adjustment can be based on the estimation results for the linear model and on other data properties such as the first few moments or autocorrelations. An illustration is given for a first‐order diagonal bilinear time series model, which in certain properties can be approximated by a linear ARMA(1, 1) model. For this case, the forecast adjustment is easy to derive, which is convenient as the particular bilinear model is indeed cumbersome to analyze in practice. An application to a range of inflation series for low‐income countries shows that such adjustment can lead to some improved forecasts, although the gain is small for this particular bilinear time series model.     

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

DNA interstrand crosslink repair requires several classes of proteins, including structure-specific endonucleases and Fanconi anemia proteins. SLX4, which coordinates three separate endonucleases, was recently recognized as an important regulator of DNA repair. Here we report the first human individuals found to have biallelic mutations in SLX4. These individuals, who were previously diagnosed as having Fanconi anemia, add SLX4 as an essential component to the FA-BRCA genome maintenance pathway.     

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis. Because increased proteolytic activity owing to mutated PRSS1 enhances the risk for chronic pancreatitis, mutations in the gene encoding anionic trypsinogen (PRSS2) may also predispose to disease. Here we analyzed PRSS2 in individuals with chronic pancreatitis and controls and found, to our surprise, that a variant of codon 191 (G191R) is overrepresented in control subjects: G191R was present in 220/6,459 (3.4%) controls but in only 32/2,466 (1.3%) affected individuals (odds ratio 0.37; P = 1.1 x 10(-8)). Upon activation by enterokinase or trypsin, purified recombinant G191R protein showed a complete loss of trypsin activity owing to the introduction of a new tryptic cleavage site that renders the enzyme hypersensitive to autocatalytic proteolysis. In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.