基于HMM的多维数据下扶贫对象状态预测

针对扶贫领域中贫困、脱贫和返贫状态预测不准确,影响状态变迁的关键因素难以识别的问题,从扶贫基础数据和多个行业数据中提取8个关键特征和22个观测状态,构建观察状态和隐含状态关联关系,建立扶贫对象状态预测隐马尔可夫模型(hidden markov model,HMM)。以某深度贫困县连续3年的数据为样本,进行参数训练、测试实验和结果验证,结果表明该方法对返贫、贫困和脱贫状态有较强的预测能力,误差率较低,且能准确识别出影响返贫的关键要素。该方法对指导精准扶贫工作具有非常重要的实际意义。     

Lawson-Mislove问题的一个必要条件

借助于Dcpo上的Scott拓扑,引进Scott吸收Dcpo的概念,并证明了函数空间上Scott拓扑与Isbell拓扑一致的必要条件是该函数空间的值域Dcpo是Scott吸收的.结果表明,Scott吸收性是Lawson-Mislove问题的一个必要性刻画.     

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

A combined genome-wide association and linkage study was used to identify loci causing variation in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10(-8)) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The association replicated in p.Phe508del homozygotes (P = 0.006) from a separate family based study (n = 557), with P = 1.49 × 10(-9) for the three-study joint meta-analysis. Linkage analysis of 486 sibling pairs from the family based study identified a significant quantitative trait locus on chromosome 20q13.2 (log(10) odds = 5.03). Our findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

Analysis for MIMO correlated frequency-selective channel in the presence of interference

The space time spreading, superimposed training sequences, and space-time coding are used to present a multiple input and multiple output （MIMO） systems model, and a closed-form of average error probability upper bound expression for MIMO correlated frequency-selective channel in the presence of interference （co-channel interference and jamming signals） is derived. Moreover, the correlation at both ends of the wireless link that can be incorporated equivalently into correlation at the transmit end is also derived, which is significant to analyze space-time link algorithm of MIMO systems.     

短波跳频FH/QDPSK系统信道自适应监测的研究(Ⅱ)

基于短波跳频FH/QDPSK系统的FFT解调,利用FFT解调的结果,提出了在瑞利衰落信道中对信道的BER进行实时自适应监测方法,该方法利用伪错监测及其非线性外推较好地解决了在较短的监测时间内获得较为精确的监测结果。模拟结果表明,采用伪错的非线性外推算法,其估值的最大绝对误差不超过0.28,最大相对误差不超过12.1%。     

HSLWAC梁收缩和徐变预应力损失试验

对5根高强轻骨料混凝土梁、1根低强轻骨料混凝土梁和1根普通混凝土梁进行了持续1年的预应力损失试验,并进行了与普通混凝土对比的收缩和徐变材性试验.试验结果表明,相同强度的轻骨料混凝土的早期收缩小于普通混凝土,后期收缩大于普通混凝土;相同强度的轻骨料混凝土徐变系数小于普通混凝土;轻骨料混凝土梁的预应力损失比普通混凝土梁的预应力损失大.结合编制的混凝土结构时随性能分析程序,基于材料收缩徐变试验进行分析,计算结果与试验结果吻合较好.采用多种规范方法对所做试验和文献的预应力损失进行了分析对比,建议了高强轻骨料混凝土梁预应力损失计算公式.     

The Moment of China's Internet Companies Management Method

文章介绍了我国互联网企业的资本结构后,从市场、技术、人力资源3个方面分析了我国互联网企业的管理之道,最后讨论了互联网企业文化建设的不足和原因.以及如何提高策略.     

Identification of susceptibility genes loci associated with type 2 diabetes

In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Han Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111875, rs1081661, rs7754840, rs4506565, rs13266634, rs4402960, and rs5643981 by using the method of polymerase chain reaction-ligase detection reaction (PCR-LDR). In a case-control study, we have genotyped the 10 candidate susceptibility SNP loci, and here, we reported that the SNP rs5219 in KCNJ1...