Genetic variation at the alcohol dehydrogenase locus inDrosophila melanogaster: A third ubiquitous allele

Summary A 3rd allele at theAdh locus,Adh ^FCh.D., has been found at polymorphic frequencies in natural populations ofD. melanogaster. The ADH-FChD enzyme has properties distinct from those of the 2 more common forms of ADH. TheAdh polymorphism should now be analyzed as a triallelic system.     

Effect of conditioned media on nerve cell differentiation

Summary Glial conditioned medium strongly stimulates the morphological maturation of cultured neuronal cells, while fibroblast and meningeal conditioned media have weaker effects.Acknowledgment. We acknowledge the expert technical assistance of Mrs M.F. Knoetgen.     

Abnormal sensitivity to erythropoietin in the erythroblast precursors in Vaquez disease]

Marrow specimens of patients with polycythemia vera rise to erythrocytic colonies in vitro without addition of erythropoietin to the culture. This behavior was never observed with marrow cells of normal subjects or secondary erythrocytosis. These results indicate that the sensitivity of some erythrocytic progenitor cells to erythropoietin is altered in polycythemia vera.     

Removal of polyethylene glycols from immunoglobulin samples by adsorption chromatography on polystyrene beads

Summary A chromatographic method is described for 80% removal of polyethylene glycol of different types, 600–6000, from human immunoglobulin preparations. Bio-beads SM-2 were used in batch procedures or packed on a 16×100 mm column. The polyethylene glycols were desorbed with 75% ethanol.     

Dialyzable serum factors alter cellular immunity in pregnancy

Summary Lymphocyte responsiveness was found to be decreased in pregnant and increased in habitually aborting women. This is attributed to a dialyzable serum factor(s), that can be removed from the surface of lymphocytes by repeated washing.     

Threo-3,4-Dihydroxyphenylserine,a poor source of noradrenaline in the rat

Résumé Chez le rat, les injections dedl-thréo-3,4-dihydroxyphénylsérine, un précurseur pharmacologique synthétique de la noradrénaline, provoquent une conversion de moins de 1% au 4-hydroxy-3-méthoxyphényl-glycol, le métabolite urinaire majeur de la noradrénaline dans cette espèce. Un nouveau cheminement qui entraîne une coupure latérale de la chaîne prit environ 10% de la dose et un autre 10% fût excrété comme un amino-acideO-méthylé; le sort de quelque 80% est inconnu.