Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.     

A kind of Generalized Learning Model

1　IntroductionSymboliclearning,connectivelearning,fuzzylearningandevolutionarylearningarethepresentfundamentalmethodsformachinelearning[1～3].Eachofthemhascharacteristicsandadvantages,andcancarryoutmachinelearningtasksincertainregioneffectively.Howe...     

红外焦平面阵列非均匀校正算法研究

红外图像的非均匀性已经成为制约红外焦平面阵列成像质量的限制性因素。本文对红外非均匀性的定义和来源进行了深入的探讨,给出了几种非均匀校正算法及其实验结果,最后对各种校正算法的特点进行了归纳总结。     

滞后广义系统的渐近稳定与镇定

广义系统的渐近稳定与镇定问题是广义系统理论的基本问题之一,在许多领域均有应用,时滞广义系统的研究与无时滞广义系统相比要困难得多。利用广义Lyapunov泛函方法研究了具滞后的广义系统的渐近稳定性和镇定问题,给出了渐近稳定判定定理,设计了适当的反馈律,以实现滞后广义系统的镇定,方法简单,直观,易于理解,给出的例子说明了该定理的可行性。     

高动态GPS/INS组合导航算法研究

首先介绍了新型深组合GPS/INS系统原理图及组合导航滤波算法。在该算法中,组合卡尔曼滤波器除完成INS误差及GPS接收机时钟误差的估计外,还参与了GPS码跟踪,即完成传统码跟踪环中环路滤波器的功能。采用自适应码跟踪误差估计器补偿组合卡尔曼滤波器测量值中的相关分量,从而消除了传统组合中不稳定的主要根源。然后进行了计算机仿真计算,仿真结果表明,新型深组合GPS/INS导航算法适用于机动性较高的载体。     

太极拳干预社区中老年人亚健康状态的临床随机对照试验

目的:评价太极拳干预中老年亚健康的疗效。方法:采用随机单盲方法,将符合亚健康诊断标准的受试者100例,随机分为太极拳干预组和一般运动干预组。两组受试者分别进行每周三次,每次30min的太极拳锻炼和一般体育运动锻炼,疗程均为16周。临床疗效观察采用SF-36生命质量评分。结果:太极拳干预组生命质量干预前后评分差值与一般体育运动组比较显示:在总体健康和生命活力两个维度的差异有统计学意义。结论:太极拳较一般运动能更好地改善中老年亚健康人群生命质量。     

Magnetocaloric effect in Er-Al-Co bulk metallic glasses

A series of Er-Al-Co bulk metallic glasses (BMGs) have been prepared by the copper mold casting method. The glass forming ability and magnetocaloric effect (MCE) for these alloys have been investigated. The second-order magnetic transition from para-magnetic to ferromagnetic states takes place at about 9 K. These BMGs exhibit excellent MCE because of their large effective magneton number; Er56Al24Co20 BMG has a maximum entropy change and refrigeration capacity of 16.06 J kg-1 K-1 and 546 J kg-1,respectively...     

RH精炼钢中全氧量变化与操作改进

为了使钢中全氧量控制在一个适当的水平,在武钢炼钢总厂RH真空脱气装置对低碳、超低碳钢进行了脱氧净化试验.结果表明,影响全氧去除的因素按作用高低依次是出钢溶解氧水平,溶解氧与钢包渣的交互作用,钢包渣,和真空处理净化时间.通过改进工艺生产了全氧量≤10×10-6,非金属夹杂物尺寸<10μm的清洁钢水,建立了一个钢包内钢水全氧浓度随时间变化的新方程,该方程考虑了全氧的表观平衡含量及环流、扩散传质对去除氧化物夹杂速率的影响.     

The determination of atmospheric phosphine in Ny-lesund

Phoshpine (PH3), a volatile and toxic gas, has been proved to commonly exist in the environment.The determination of gaseous phosphine and its emission fluxes in Ny-lesund is reported in this paper.Results showed that gaseous phosphine exist in Arctic atmosphere commonly and the concentration of phosphine ranged from 16.3-600.2 ng/m3, with the maximum concentration of phosphine in tundra areas and the minimum in surface air of ocean.The concentration of phosphine ranged from 65.79-1259 ng/m3 in colliery at...     

SP 3D在硫磺回收项目中的定制与开发应用

采用三维工厂设计系统SP 3D对某硫磺回收装置项目开展布置设计的过程中,通过定制、扩展和二次开发等工作,达到完善设计标准数据库和更加智能化工作的目的。举例介绍了管架数据库扩展、图面定制二次开发和地下管线交叉点报告等工作,展示了专业知识与专业软件的深入结合,可以提升设计效率和降低设计错误,从而提高了工程设计质量。