短波CHESS跳频系统的性能分析

以提高短波数据传输速率为主要目的的CHESS系统及技术目前受到普遍关注.先介绍了CHESS系统,对其核心技术--差分跳频的原理、相应G函数跳频图案的性能进行了研究,并对其性能进行了检验,得出了一些有益的结论.     

微量Mg对纯Ag的性能影响

 在99.995%Ag中添加8×10^-5Mg制成99.99%纯Ag,进行机械性能测试试验.当ε=98%时,在25℃下保存200d,其强度和硬度稳定不变.即在99.995%的高纯Ag中存在有微量镁,使Ag在结晶过程中出现少量Ag溶Mg的固溶体颗粒,细化Ag的晶粒,晶界增多,变形抗力增大.起到强化和稳定机械性能的作用.     

核辐射技术及其在材料科学领域的应用

核辐射技术在材料科学领域得到了广泛的应用,利用辐射技术对无机材料、高分子材料进行改性和加工已成为一支新兴的高技术产业。综述了辐射技术在材料的改性和加工领域的应用研究进展,并详细介绍该单位在采用反应堆辐照技术研制碳化硅（SiC）陶瓷纤维、辐射交联法制备三元乙丙橡胶（EPDM）密封材料、辐射接枝合成偕胺肟型螯合树脂等方面开展的工作。     

12CaO·7Al2O3型精炼合成渣物性与脱硫试验

对近两年从国外发展起来的新型精炼合成渣 12 Ca O· 7Al2 O3的烧成工艺、物性和脱硫能力进行了试验研究。结果表明 ,该渣系原料来源广泛 ,成本较低 ;以 12 Ca O· 7Al2 O3为低熔点相 ,具有较低的熔化温度 ,在精炼温度下具有较好的流动性 ;由于具有很高的碱度和 Al2 O3含量 ,因而具有较强的脱硫能力和吸附铝脱氧产物的能力 ,并且在精炼过程中还可配加大量石灰 ,进一步提高其脱硫能力 ,尤其适用于铝脱氧钢     

Ciliary proteins Fap43 and Fap44 interact with each other and are essential for proper cilia and flagella beating

Cilia beating is powered by the inner and outer dynein arms (IDAs and ODAs). These multi-subunit macrocomplexes are arranged in two rows on each outer doublet along the entire cilium length, except its distal end. To generate cilia beating, the activity of ODAs and IDAs must be strictly regulated locally by interactions with the dynein arm-associated structures within each ciliary unit and coordinated globally in time and space between doublets and along the axoneme. Here, we provide evidence of a novel ciliary complex composed of two conserved WD-repeat proteins, Fap43p and Fap44p. This complex is adjacent to another WD-repeat protein, Fap57p, and most likely the two-headed inner dynein arm, IDA I1. Loss of either protein results in altered waveform, beat stroke and reduced swimming speed. The ciliary localization of Fap43p and Fap44p is interdependent in the ciliate Tetrahymena thermophila.     

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy.     

Control of a key transition from prostrate to erect growth in rice domestication

The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication.     

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder.     

基于功率谱密度与随机配置网络的低压串联电弧故障检测

低压串联电弧电流为非平稳信号,故障特征区分度低且具有随机性,给电弧故障特征提取和准确检测带来困难,提出了基于功率谱密度与随机配置网络的低压串联电弧故障检测方法。首先,搭建了串联电弧故障发生平台,采集不同负载类型的电流数据,构建数据集。其次,采用功率谱密度对电流信号执行随机信号分析,实现对电流信号的定量化频域特征描述,增强故障电流与正常电流特征的区分度。然后,采用随机配置网络构建串联电弧故障检测模型,将功率谱密度特征用于随机配置网络的自适应训练学习,提升网络训练效率和模型故障检测能力。在本文构建的电流数据集上,串联电弧故障检测的平均准确率达到96.156 7%,证明了方法的有效性。     

剪切闸板防喷器剪切性能评价

剪切闸板防喷器是井控设备的重要组成部分之一,其作用是在钻井过程中遇到突发情况时及时剪断钻杆并密封井口,其剪切性能直接关系到钻井作业的安全.以某新型上直下V结构的剪切闸板防喷器为研究对象,通过显示动力学模块对剪切闸板剪切钻杆的过程进行数值仿真模拟,分析研究闸板的剪切性能.并用该剪切闸板分别剪切5 in和5.5 in两种不...