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排序方式: 共有419条查询结果,搜索用时 375 毫秒
21.
Frank W. Pfrieger 《Cellular and molecular life sciences : CMLS》2009,66(13):2037-2047
Brain function relies on communication among neurons via highly specialized contacts, the synapses, and synaptic dysfunction lies at the heart of age-, disease-, and injury-induced defects of the nervous system. For these reasons, the formation—and repair—of synaptic connections is a major focus of neuroscience research. In this review, I summarize recent evidence that synapse development is not a cell-autonomous process and that its distinct phases depend on assistance from the so-called glial cells. The results supporting this view concern synapses in the central nervous system as well as neuromuscular junctions and originate from experimental models ranging from cell cultures to living flies, worms, and mice. Peeking at the future, I will highlight recent technical advances that are likely to revolutionize our views on synapse–glia interactions in the developing, adult and diseased brain. 相似文献
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Daniel Umlauf Svetlana Frank Thomas Pap Jessica Bertrand 《Cellular and molecular life sciences : CMLS》2010,67(24):4197-4211
Osteoarthritis is one of the most common forms of musculoskeletal disease and the most prominent type of arthritis encountered in all countries. Although great efforts have been made to investigate cartilage biology and osteoarthritis pathology, the treatment has lagged behind that of other arthritides, as there is a lack of effective disease-modifying therapies. Numerous approaches for dealing with cartilage degradation have been tried, but enjoyed very little success to develop approved OA treatments with not only symptomatic improvement but also structure-modifying effect. In this review we discuss the most recent findings regarding the regulation of cartilage biology and pathology and highlight their potential therapeutic values. 相似文献
24.
Jayantha Arnold Arvind Sangwaiya Vijay Manglam Frank Geoghegan Mark Thursz Mark Busbridge 《河南科技》2010,(3)
AIM: To examine body fluids such as ascitic fluid (AF),saliva,bile and pleural effusions for the presence of hepcidin using a novel radioimmunoassay (RIA).METHODS: Serum samples were collected from 25 healthy volunteers (mean age: 36 ± 11.9 years,11 males,14 females).In addition bile was obtained from 12 patients undergoing endoscopic retrograde cholangiopancreatography (mean age: 66.9 ± 16.7 years,M:F = 5:7).Saliva was collected from 17 healthy volunteers (mean age: 35 ± 9.9 years,M:F = 8:9).Pleural and AF... 相似文献
25.
Metallurgy: high nickel release from 1- and 2-euro coins 总被引:1,自引:0,他引:1
The amount of nickel is regulated in European products that come into direct and prolonged contact with human skin because this metal may cause contact allergy, particularly hand eczema. Here we show that 1- and 2-euro coins induce positive skin-test reactions in sensitized individuals and release 240-320-fold more nickel than is allowed under the European Union Nickel Directive. A factor contributing to this high release of nickel is corrosion due to the bimetallic structure of these coins, which generates a galvanic potential of 30-40 mV in human sweat. 相似文献
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提出了一种由样品辨识、模糊推理和控制处理 3个子网模块构成的基于知识的多层神经网络 .这种网络由各子网分别构成并按照最初的模糊控制结构适当连接而建立 ,具有明确区分各组成子网功能及其知识流结构 .由于综合了模糊逻辑的推理过程及神经网络的学习能力 ,使它能够在其结构中以模糊规则的形式引入语言知识并通过网络的训练及自学习对这些知识进行加工 ,从而实现了真正意义上的自适应模糊控制器 .最后还讨论了这种 NFN网络在动态过程控制中的应用 相似文献
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The homeotic protein AGAMOUS controls microsporogenesis by regulation of SPOROCYTELESS 总被引:1,自引:0,他引:1
Ito T Wellmer F Yu H Das P Ito N Alves-Ferreira M Riechmann JL Meyerowitz EM 《Nature》2004,430(6997):356-360
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Deloukas P Earthrowl ME Grafham DV Rubenfield M French L Steward CA Sims SK Jones MC Searle S Scott C Howe K Hunt SE Andrews TD Gilbert JG Swarbreck D Ashurst JL Taylor A Battles J Bird CP Ainscough R Almeida JP Ashwell RI Ambrose KD Babbage AK Bagguley CL Bailey J Banerjee R Bates K Beasley H Bray-Allen S Brown AJ Brown JY Burford DC Burrill W Burton J Cahill P Camire D Carter NP Chapman JC Clark SY Clarke G Clee CM Clegg S Corby N Coulson A Dhami P Dutta I Dunn M Faulkner L Frankish A 《Nature》2004,429(6990):375-381
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