插装阀组集成控制液压系统瞬时失效机理解析

为从理论上揭示插装阀组集成控制液压系统瞬时失效的原因,以混凝土泵液压系统为例,提出了基于流体逻辑理论的插装阀组启闭状态组合的解析方法,并运用混凝土泵液压系统的数字化模型验证其有效性.研究结果表明,当负载处于一定范围时,个别插装阀的不当开启会导致不同插装阀的容腔短暂串通,造成液压系统的瞬时失效,而增加插装阀控制腔压力可以...     

货架摆放量影响需求的库存管理

建立某些商品的需求与库存管理模型,从商品自身的销售弹性与替代品的销售弹性出发,设定摆放量充足时货架摆放量与需求量是指数函数关系;当摆放量小于一定量时,顾客的需求为一常数,并且允许顾客流失和延迟销售;在此基础上建立货架摆放量与需求量的模型.并通过解析解的情况,求出最优解.     

变压器设计原则的探讨

变压器是指用来改变交流电压大小的一种电气设备。它是根据电磁感应的设计原理,把某一等级交流的电压变换成另一等级交流的电压,从而满足不同负荷的需要。变压器不论在工作还是在生活中都有非常重要的作用,而且越来越得到广泛的应用和推广。其安全可靠性也是变压器发展的最大瓶颈,因此变压器在电力系统、供用电系统等各大系统中都占有举足轻重的作用。文章就变压器的设计原则、原理特点进行一定的探讨。     

Evidence for a spin-aligned neutron-proton paired phase from the level structure of (92)Pd

Shell structure and magic numbers in atomic nuclei were generally explained by pioneering work that introduced a strong spin-orbit interaction to the nuclear shell model potential. However, knowledge of nuclear forces and the mechanisms governing the structure of nuclei, in particular far from stability, is still incomplete. In nuclei with equal neutron and proton numbers (N = Z), enhanced correlations arise between neutrons and protons (two distinct types of fermions) that occupy orbitals with the same quantum numbers. Such correlations have been predicted to favour an unusual type of nuclear superfluidity, termed isoscalar neutron-proton pairing, in addition to normal isovector pairing. Despite many experimental efforts, these predictions have not been confirmed. Here we report the experimental observation of excited states in the N = Z = 46 nucleus (92)Pd. Gamma rays emitted following the (58)Ni((36)Ar,2n)(92)Pd fusion-evaporation reaction were identified using a combination of state-of-the-art high-resolution γ-ray, charged-particle and neutron detector systems. Our results reveal evidence for a spin-aligned, isoscalar neutron-proton coupling scheme, different from the previous prediction. We suggest that this coupling scheme replaces normal superfluidity (characterized by seniority coupling) in the ground and low-lying excited states of the heaviest N = Z nuclei. Such strong, isoscalar neutron-proton correlations would have a considerable impact on the nuclear level structure and possibly influence the dynamics of rapid proton capture in stellar nucleosynthesis.     

抗蛔虫人源单链抗体库的构建及鉴定

目的:构建抗蛔虫人源单链抗体库,从中筛选建抗蛔虫人源特异性单链抗体.方法:分离10个患蛔虫病人的淋巴细胞,提取总RNA反转录为cDNA,PCR扩增人抗体重链(VH)和轻链(VL)可变区基因,采用SOE-PCR法将VH和VL片段随机拼接成scFv片段,并克隆入噬菌粒载体pCANTAB5E中,构建噬菌体单链抗体库.结果:初...     

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in principle, reversible and often amenable to drug intervention, the promise of targeting such pathways therapeutically has been limited by an incomplete understanding of cancer-specific dependencies on epigenetic regulators. Here we describe a non-biased approach to probe epigenetic vulnerabilities in acute myeloid leukaemia (AML), an aggressive haematopoietic malignancy that is often associated with aberrant chromatin states. By screening a custom library of small hairpin RNAs (shRNAs) targeting known chromatin regulators in a genetically defined AML mouse model, we identify the protein bromodomain-containing 4 (Brd4) as being critically required for disease maintenance. Suppression of Brd4 using shRNAs or the small-molecule inhibitor JQ1 led to robust antileukaemic effects in vitro and in vivo, accompanied by terminal myeloid differentiation and elimination of leukaemia stem cells. Similar sensitivities were observed in a variety of human AML cell lines and primary patient samples, revealing that JQ1 has broad activity in diverse AML subtypes. The effects of Brd4 suppression are, at least in part, due to its role in sustaining Myc expression to promote aberrant self-renewal, which implicates JQ1 as a pharmacological means to suppress MYC in cancer. Our results establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in AML and, potentially, other cancers, and highlight the utility of RNA interference (RNAi) screening for revealing epigenetic vulnerabilities that can be exploited for direct pharmacological intervention.     

CaWO4:Eu3+,M3+(M=Tb,Sm,Bi,Dy)的水热合成及发光性能研究

利用水热合成法制备CaWO4∶Eu3+以及CaWO4∶Eu3+,M3+(M=Tb,Sm,Bi,Dy)系列钨酸盐基荧光粉,利用XRD表征产物CaWO4∶Eu3+(5%)的晶体结构,结果表明其结构和CaWO4的标准物相结构相似,为四方晶系结构;研究了CaWO4∶Eu3+的发光性能以及第二掺杂离子M3+(M=Tb,Sm,Bi...     

公路下充填开采的相似材料及数值模拟研究

针对公路下大量压煤的实际情况,为尝试性地探索公路下采煤的合适方法,利用相似材料模拟实验对公路下充填开采进行了研究,通过实验得到了公路在充填开采状态下所产生的移动和变形值;同时利用有限元软件ADINA进行三维数值模拟,将数值模拟与相似材料模拟实验的结果进行了对比分析,并研究了开采时煤层倾角、采深对公路稳定性的影响.研究表...     

光肩星天牛对糖槭挥发物的EAG及嗅觉行为反应

[目的]分析影响光肩星天牛定位寄主的糖槭挥发物成分,解析挥发物在光肩星天牛搜寻和定位寄主过程中的作用,为光肩星天牛的综合防控提供依据.[方法]利用热脱附气质联用法(thermal desorption gas chromatog-raphy-mass spectrometry,TCT-GC-MS)分析鉴定糖槭挥发物组分...     

南江峡谷公园陆生贝类物种多样性研究

对南江峡谷公园不同生境陆生软体动物的物种多样性进行了研究,在4个不同生境中进行了定量调查和采集,共获5 000余号标本,经鉴定,得65种,隶属于2个亚纲2目11科36属。多样性分析结果表明:4种不同生境的物种丰富度指数DMA的取值范围在1.092~4.492之间,多样性指数H′的范围是0.812~0.903,均匀度指数Jsw为0.250~0.505。根据不同生境物种的相似性系数CC进行系统聚类,4种生境在相似性系数为0.250水平时以被归并为两组,即原生森林组和次生环境组。原生森林一旦遭受彻底破坏,其内原有的陆生贝类物种种类和数量将会显著下降。