科学基金与口腔医学

口腔医学是医学的一个重要分支,它涉及口腔及其相关器官疾病(包括口颌面软硬组织的损伤、疾病和口颌发育异常等)的预防、诊断和治疗。口腔医学在基础理论、研究方法与医学其他分支学科类似。但是,口腔医学由于它所研究器官的特殊性,在疾病的诊断和治疗方法上与医学其他学科也有     

细胞因子诱导的NK细胞过继免疫治疗恶性肿瘤的初步应用

目的　采集不同类型恶性肿瘤患者外周血,扩增CINK细胞,并观察自体CINK细胞过继免疫治疗的疗效和安全性.方法　利用抗CD3 单抗、IL-2、PHA从9 例肿瘤患者PBMC中诱导扩增CINK细胞,2 周左右开始自体回输.结果　CINK细胞经培养后细胞总数和CD3- CD56+NK细胞均获大量增殖.肿瘤患者经自体CINK 细胞免疫治疗后, CD3、CD4 T 细胞、NK 细胞、CD4/CD8的比例均显著提高(P<0.01),睡眠、食欲等指标也有相应改善,治疗过程中未见副作用. 结论　自体CINK细胞过继免疫治疗可以显著提高患者免疫功能,改善患者生活质量,且副作用小.     

期权费用化小议

股票期权制度成为安然事件后会计界备受关注的一个新兴领域，本文通过对美国股票期权会计理论发展的分析．对我国股票期权制度在现阶段的实施提出了一些建议。     

用Visual Basic设计屏幕保护程序

本文论述了屏幕保护程序的特点,讨论了如何用VisualBasic设计屏幕保护程序,通过典型的设计示例说明了屏幕保护程序的设计。     

陶瓷化学镀镍的研究

研究了陶瓷化学镀镍的实验操作方法、工艺条件及各种因素对镀层的影响,确定了陶瓷镀镍的最佳工艺方法及控制条件.     

基于SIFT的车标识别算法

针对车标识别过程中匹配阈值难、识别速度慢的问题,提出一种基于尺度不变特征变换(SIFT)的特征匹配车标识别算法.利用SIFT算子对图像的视角、平移、放射、亮度、旋转等不变特性进行提取,并采用BP神经网络算法自主选取车标图像特征进行分类、匹配和识别.仿真实验结果表明,简单车标和复杂车标的识别率平均值均达90%以上,该算法识别速度较快、识别率较高,能满足实际应用的需要.     

双积分制下汽车生产商生产决策优化

本文研究了燃料消耗量积分和新能源汽车积分"双积分制"下汽车生产商生产决策问题,基于持股比例和内部期权协议建立了传统能源车与新能源汽车联合决策模型,在积分不足、积分富余和积分平衡三种策略情形下求解了最优定价、产量和内部积分协议价,并针对市场积分价格和汽车销售量的实际波动求解了生产计划的鲁棒区间及其应急调整策略.研究结果表明:持股比例主要影响内部协议价形成,持股比例越高,内部协议价越趋近于外部市场价;初始生产计划存在多维非对称鲁棒区间,汽车生产商可通过价格响应机制实现生产计划扰动管理及积分策略切换;控制积分交易限量将改变最优生产计划及其应急调整策略.     

Leaching behavior of V,Pb, Cd,Cr, and As from stone coal waste rock with different particle sizes

This paper investigates the leaching behavior of heavy metals (V, Pb, Cd, Cr, and As) from stone coal waste rocks with various particle sizes using dynamic leaching experiments. The results show that the dissolved concentrations of V and As initially increased and then slightly decreased as time progressed and that the dissolved concentrations of Pb, Cd, and Cr were high in the early stage before decreasing. The particle size of the stone coal waste rocks strongly influenced the heavy metal concentration in the leaching solutions. The effects of the particle size of the stone coal waste rocks on the dissolved concentrations of V, Pb, and As decreased in the order fine fraction > medium fraction > coarse fraction, and the effects of particle size on the dissolved concentrations of Cr and Cd decreased in the order medium fraction > coarse fraction > fine fraction and coarse fraction > medium fraction > fine fraction, respectively. The quantities of heavy metals dissolved from the stone coal waste rock with fine particle sizes were observed to decrease in the order V (17104.36 μg/kg) > As (609.41 μg/kg) > Pb (469.24 μg/kg) > Cr (56.35 μg/kg) > Cd (27.52 μg/kg), and the dissolution rates decreased in the order As (2.96%) > Pb (0.93%) > V (0.35%) > Cd (0.25%) > Cr (0.01%). The specific surface area, pore size of the stone coal waste rocks, and chemical forms of heavy metals also influenced the release of heavy metals from the stone coal waste rocks. Kinetic analysis showed that the dissolution of heavy metals fundamentally agreed with the rate equation controlled by the shrinking core model. The results of this study are expected to serve as a reference for the evaluation of heavy metals contamination from stone coal waste rocks.     

The hidden disintegration of cluster heterogeneity in Fe-based glass-forming alloy melt

The evolution of liquid metal at high temperature is known much less than their solid states. This is partially due to that the message concerning clusters, metastable phase or heterogeneity in liquid is usually too slight to be traced. Here, we shed some light on the nature of structural evolution of Fe-based glass-forming alloy during overheating process by the investigation of high-temperature melt viscometry and first principles simulations. It was found that a structural transition around 1400 ℃ occurred in the melts of initial homogeneous ingot, heterogeneous ingot and amorphous ribbons jointly, and was confirmed by the results from differential scanning calorimeter(DSC), and ab initio molecular dynamics(AIMD). Combining these results with Fe-Si-B ternary phase diagram and the melting characteristics of Fe-B compounds, it is safe to conclude that the disintegration of Fe_2B type clusters to Fe_3B-type clusters leads to the observed transition. These results offer a significant reference for the preparation and property control of Fe-based amorphous alloys.     

酸性木聚糖酶产生菌XYW5的筛选及酶学性质

【目的】选育优良的产酸性木聚糖酶的微生物,考察酸性木聚糖酶的酶学性质(尤其是pH值为4.0),为实现纤维素乙醇低成本清洁生产打下基础。【方法】从广西大学农场采集土壤,富集后经产酸性木聚糖酶的培养,比较酸性木聚糖酶酶活力,选育酸性木聚糖酶高产菌株,鉴定菌种,分析酶学性质。【结果】筛选出产酸性木聚糖酶酶活力较高的菌株XYW5。扩增菌株XYW5的ITS rDNA序列,经测序分析比对,将其初步鉴定为日本曲霉Aspergillus japonicus XYW5。菌株XYW5产酸性木聚糖酶和酸性木糖苷酶的酶活力最高分别达(26. 26±0. 97)U/mL和(0.63±0.02) U/mL,比活力分别为(85.50±0.63) U/mg和(1.80±0.01) U/mg;其酸性木聚糖酶最适温度和最适pH值分别为65℃和6.5,酸性木糖苷酶最适温度和最适pH值分别为70℃和4.5;酸性木聚糖酶兼有酸性CMCase酶活力,达到8.54 U/mL。【结论】菌株XYW5所产的酸性木聚糖酶具有开发成为优良工业酸性木聚糖酶的潜力。