Planetary science: bedrock formation at Meridiani Planum

The Mars Exploration Rover Opportunity discovered sulphate-rich sedimentary rocks at Meridiani Planum on Mars, which are interpreted by McCollom and Hynek as altered volcanic rocks. However, their conclusions are derived from an incorrect representation of our depositional model, which is upheld by more recent Rover data. We contend that all the available data still support an aeolian and aqueous sedimentary origin for Meridiani bedrock.     

The autonomy of models and explanation: anomalous molecular rearrangements in early twentieth-century physical organic chemistry

During the 1930s and 1940s, American physical organic chemists employed electronic theories of reaction mechanisms to construct models offering explanations of organic reactions. But two molecular rearrangements presented enormous challenges to model construction. The Claisen and Cope rearrangements were predominantly inaccessible to experimental investigation and they confounded explanation in theoretical terms. Drawing on the idea that models can be autonomous agents in the production of scientific knowledge, I argue that one group of models in particular were functionally autonomous from the Hughes–Ingold theory. Cope and Hardy’s models of the Claisen and Cope rearrangements were resources for the exploration of the Hughes–Ingold theory that otherwise lacked explanatory power. By generating ‘how-possibly’ explanations, these models explained how these rearrangements could happen rather than why they did happen. Furthermore, although these models were apparently closely connected to theory in terms of their construction, I argue that partial autonomy issued in extra-logical factors concerning the attitudes of American chemists to the Hughes–Ingold theory. And in the absence of a complete theoretical hegemony, a degree of consensus was reached concerning modelling the Claisen rearrangement mechanism.     

Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface.

Activated platelets bind numerous adhesive and procoagulant proteins by receptor-mediated processes. Although there is little evidence to suggest that these processes are heterogeneous in platelets, we previously found that platelets co-stimulated with collagen and thrombin express functional alpha-granule factor V only on a subpopulation of cells. Here we show that these cells, referred to as 'COAT-platelets', bind additional alpha-granule proteins, including fibrinogen, von Willebrand factor, thrombospondin, fibronectin and alpha2-antiplasmin. These proteins are all transglutaminase substrates, and inhibitors of transglutaminase prevent the production of COAT-platelets. A synthetic transglutaminase substrate (CP15) also binds to COAT-platelets, and analysis by high performance liquid chromatography/mass spectrometry shows that a product is formed with a relative molecular mass (Mr) equal to CP15 plus 176. Serotonin, an abundant component of platelet-dense granules, has an Mr of 176, and fibrinogen isolated from COAT-platelets contains covalently linked serotonin. Synthetic bovine serum albumin-(serotonin)6 binds selectively to COAT-platelets and also inhibits the retention of procoagulant proteins on COAT-platelets. These data indicate that COAT-platelets use serotonin conjugation to augment the retention of procoagulant proteins on their cell surface through an as yet unidentified serotonin receptor.     

Circuit cavity electromechanics in the strong-coupling regime

Demonstrating and exploiting the quantum nature of macroscopic mechanical objects would help us to investigate directly the limitations of quantum-based measurements and quantum information protocols, as well as to test long-standing questions about macroscopic quantum coherence. Central to this effort is the necessity of long-lived mechanical states. Previous efforts have witnessed quantum behaviour, but for a low-quality-factor mechanical system. The field of cavity optomechanics and electromechanics, in which a high-quality-factor mechanical oscillator is parametrically coupled to an electromagnetic cavity resonance, provides a practical architecture for cooling, manipulation and detection of motion at the quantum level. One requirement is strong coupling, in which the interaction between the two systems is faster than the dissipation of energy from either system. Here, by incorporating a free-standing, flexible aluminium membrane into a lumped-element superconducting resonant cavity, we have increased the single-photon coupling strength between these two systems by more than two orders of magnitude, compared to previously obtained coupling strengths. A parametric drive tone at the difference frequency between the mechanical oscillator and the cavity resonance dramatically increases the overall coupling strength, allowing us to completely enter the quantum-enabled, strong-coupling regime. This is evidenced by a maximum normal-mode splitting of nearly six bare cavity linewidths. Spectroscopic measurements of these 'dressed states' are in excellent quantitative agreement with recent theoretical predictions. The basic circuit architecture presented here provides a feasible path to ground-state cooling and subsequent coherent control and measurement of long-lived quantum states of mechanical motion.     

Protein Phosphorylation Site Prediction via Feature Discovery Support Vector Machine

Protein phosphorylation/dephosphorylation is the central mechanism of post-translational modification which regulates cellular responses and phenotypes. Due to the efficiency and resource constraints of the in vivo methods for identifying phosphorylation sites, there is a strong motivation to computationally predict potential phosphorylation sites. In this work, we propose to use a unique set of features to represent the peptides surrounding the amino acid sites of interest and use feature selection support vector machine to predict whether the serine/threonine sites are potentially phosphorylable, as well as selecting important features that may lead to phosphorylation. Experimental results indicate that the new features and the prediction method can more effectively predict protein phosphorylation sites than the existing state of the art methods. The features selected by our prediction model provide biological insights to the in vivo phosphorylation.     

Student, Curricular and Public Agency Needs: A Focus on Competency Achievement

This paper presents a framework that addresses a public child welfare agency??s need for a highly trained child welfare workforce with specialized competencies, situating these competencies within the human services educational profession??s accreditation standards, while simultaneously meeting the learning needs of professionals returning to school for additional graduate training. The framework integrates three disparate literatures. The first that frames employees returning to a university setting for additional education and training as a human resources benefit. The second body of literature that addresses the annual review of employee performance via employment assessment systems. And the final body that examines parallel organizational processes related to the development of a product, in our case, a professional with a graduate degree. The framework, developed using a soft system methodology approach, and evaluated by means of an electronic portfolio, integrates these three bodies of literature and allows for the real time curricular and agency assessment of competency achievement. While using a professional graduate training program as an exemplar, implications for broader systemic practice are discussed.     

Effects of 2,4-D on a Populus tremuloides community in the western United States-22 years after treatment

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Quaking aspen ( Populus tremuloides Michx.) stands were accidentally sprayed with 2,4-D in a sagebrush control program in western Wyoming in 1958. We visited the site during the summer of 1981 to evaluate the long-term effect on the aspen trees and the associated vegetation. Initially, some observers believed that the aspen had been “destroyed.” Subsequent data indicate just the opposite—aspen stocking appeared to have been improved by the treatment. On two of the sampled clones, 22 years after spraying, there were approximately 17,000 more suckers/ha on the sprayed than on the unsprayed plots. These are adequate numbers to restock the site to pretreatment densities. Although undergrowth vegetation appeared to be changed as a result of the treatment, this cannot be attributed solely to the herbicide because heavy grazing, mostly by domestic livestock, has occurred on the grazing allotment. A similarity index was calculated between sprayed and unsprayed portions of the same aspen clones. Forbs were still less on the sprayed areas, whereas grasses were similar on the sprayed and unsprayed areas. Spraying apparently does not have as adverse an effect on aspen communities as some conservationists originally thought.        

Kramer Palouse natural area

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The 27-acre Kramer Palouse Natural Area located in southeastern Washington State represents the best remaining example of what was once the most productive portion of the original Palouse Prairie. This area is being maintained in its pristine condition as a key to the past and as a memory to a unique and once extensive prairie land by the Department of Forestry and Range Management at Washington State University.