一种基于多任务学习的多模态情感识别方法

为了通过设置辅助任务学习到更具有情感倾向性的视频和语音表示,进而提升模态融合的效果,提出一种基于多任务学习的多模态情感识别模型,使用多模态共享层来学习视觉和语音模型的情感信息.在MOSI数据集和MOSEI数据集上的实验表明,添加两个辅助的单模态情感识别任务后,模型可以学习到更有效的单模态情感表示,并且在两个数据集上的情...     

钢筋混凝土十字形异形柱-板柱连接抗弯承载力的研究

为了研究柱截面形式为异形柱的板柱连接冲切受力性能,进行了柱截面形状分别为3种典型异形柱(十字形、T形和L形)和对比方柱所构成的板柱连接的冲切特性试验.根据所进行的柱截面为十字形异形柱-板柱连接冲切特性的试验成果,提出了十字形柱-板柱连接的屈服线形式,并应用屈服线理论,导出了十字形异形柱-板柱连接的抗弯承载力表达式.该式形式简单、应用方便,其理论计算值与试验值比较,符合较好.结果可供类似柱形的板柱连接强度计算时参考.     

相容粗糙集在音频检索中的应用

针对数字技术的发展促使个人的多媒体数据资料量越来越大,给人们的使用造成很大的不便,人们迫切需要能对这些资料进行检索和管理的工具,提出了利用相容粗糙集理论对音频数据进行预检索的新方法,即在相容类的近似空间中对音频数据进行预检索.实验结果表明,该方法可以有效地克服等价粗糙集在音频检索方面的限制,对提高检索效率具有一定的作用.     

板式换热器中蒸汽凝结换热特性

在板式换热器的蒸汽凝结换热试验台上进行了实验研究,获取蒸汽完全凝结和部分凝结两种典型工况下的换热和压降特性．且就板式换热器中蒸汽凝结过程的换热进行分析和处理,得到了一个在板片槽道中蒸汽凝结换热系数关联式．并推荐用于板式换热器的蒸汽凝结换热系数的计算．     

Effects of electromagnetic field and lubricate condition on the surface quality of magnesium alloy billet during LFEC processing

The microstructures of the magnesium billets could be improved markedly by low-frequency electromagnetic casting(LFEC)processing.In fact,the low-frequency electromagnetic field(LFEF)also has favorite effect on the surface quality of billet.However,few public reports on the surface quality of LFEC magnesium billets could be found.Therefore,a new crystallizer with a metal internal sleeve together with a kind of lubricant was designed aiming at lowing surface turning quantity,and the effects of casting velocit...     

External synchronization of two dynamical systems with uncertain parameters

External synchronization is addressed as two or more dynamical systems with synchronous motions, which is also regarded as master-slave system. In this paper, two dynamical systems, one employs a hysteretic term to model the friction phenomenon, the other involves a hardening stiffness component with the third order of displacement due to flexible deformation, are controlled to converge to the same trajectory. The control strategy is extended from feedback control for all parameters known to adaptive contro...     

重症急性胰腺炎病人外周血单个核细胞线粒体DNA拷贝数的意义

目的探讨重症急性胰腺炎患者外周血单个核细胞线粒体DNA拷贝数与患者病情严重程度、预后的相关性。方法分离研究对象（重症急性胰腺炎患者34名,健康对照组17名）外周血单个核细胞,采用荧光实时定量PCR检测各组PBMC线粒体DNA相对舍量,其与严重程度、预后的相关性。结果重症急性胰腺炎患者线粒体DNA含量较健康对照组明显降低（P〈0．05）。患者单个核细胞线粒体DNA拷贝教与APACHEⅡ评分呈负相关（r=-0．425）其中并发症组mtDNA拷贝数显著低于无并发症组（P〈0．05）。结论重症急性胰腺炎患者外周血单个核细胞中线粒体DNA含量显著下降,与患者APACHEⅡ评分呈负相关,且低水平的线粒体DNA拷贝数提示并发症发生率的升高,因此,线粒体DNA拷贝数可作为潜在评估患者病情危重程度及预后的指标,这一发现值得进一步大型,前瞻性的研究。     

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.     

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.     

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

Strong signatures of positive selection at newly arising genetic variants are well documented in humans, but this form of selection may not be widespread in recent human evolution. Because many human traits are highly polygenic and partly determined by common, ancient genetic variation, an alternative model for rapid genetic adaptation has been proposed: weak selection acting on many pre-existing (standing) genetic variants, or polygenic adaptation. By studying height, a classic polygenic trait, we demonstrate the first human signature of widespread selection on standing variation. We show that frequencies of alleles associated with increased height, both at known loci and genome wide, are systematically elevated in Northern Europeans compared with Southern Europeans (P < 4.3 × 10(-4)). This pattern mirrors intra-European height differences and is not confounded by ancestry or other ascertainment biases. The systematic frequency differences are consistent with the presence of widespread weak selection (selection coefficients ～10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15)).