水泥稳定碎石底基层试验段施工技术的探讨

通过对试验段的施工来检验并确定水泥稳定碎石底基层及试验段混合料的施工配合比、试验段主要施工人员及机械设备配置试验段所需材料的各项技术参数试验段的施工工艺和施工方法。     

知识与政治:女性主义立场论的批判性反思

本文分析了女性主义立场论与马克思主义阶级立场理论的亲合与分离以及其激进的政治立场所面临的困境,指出当放弃了对多元立场的独断论的政治赋权,温和的女性主义立场论对科学与政治关系的认识将呈现出更民主与更合理的理论向度。     

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140?mm?Hg systolic blood pressure or ≥90?mm?Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.     

黑龙江七星河国家级湿地自然保护区生态旅游开发的SWOT分析

采用SWOT分析法较为详细地分析了七星河国家级湿地自然保护区发展生态旅游业的优势、弱势、机遇和威胁。得出黑龙江七星国家级河湿地自然保护区不仅具备景观资源独特、动植物资源丰富、旅游环境优越等开展湿地生态旅游的先决条件,而且拥有国内外生态旅游发展的有利形势和地方政策大力支持的大好机遇;但同时存在湿地保护和专业人员匮乏、旅游...     

SolidWorks与Pro/Engineer之间图形数据交换方式的研究

以设计单缸柴油机时所遇到的Solid Works与Pro/E之间图形数据交换问题为例,对IGES,Parasolid 和STEP三种数据交换标准作了比较分析,提出了基于STEP标准实现数据交换的方法,应用此方法提高了单缸柴油机设计效率.同时介绍了SolidWorks软件中特有的特征识别(Feature Works)功能...     

海岸带生态健康评价方法综述

生态健康是指人与环境关系的健康,是测度人的生产生活环境及其赖以生存的生命支持系统的代谢过程和服务功能完好程度的系统指标,包括人体和人群的生理和心理生态健康、人居物理环境、生物环境和代谢环境的健康及产业和区域生态服务功能的健康.文章综述了海岸带生态健康评价的主要方法.这些方法不仅可用于海岸带的生态健康评价,同样可用于其他生态系统的健康评价.     

我国化学化工领域毕业生及学位授予情况的调研与分析

本文基于对我国化学化工领域2006-2010年间本科生、硕士研究生和博士研究生培养情况的调研数据,分析了不同学位层次毕业生数量变化趋势、毕业生在各学科门类及培养单位的分布情况,进而讨论了我国化学化工领域学生培养的结构特点及人才队伍趋势.     

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in social interactions, deficits in communication as well as restricted interests and repetitive behaviours. The neurological basis and circuitry mechanisms underlying these abnormal behaviours are poorly understood. SHANK3 is a postsynaptic protein, whose disruption at the genetic level is thought to be responsible for the development of 22q13 deletion syndrome (Phelan-McDermid syndrome) and other non-syndromic ASDs. Here we show that mice with Shank3 gene deletions exhibit self-injurious repetitive grooming and deficits in social interaction. Cellular, electrophysiological and biochemical analyses uncovered defects at striatal synapses and cortico-striatal circuits in Shank3 mutant mice. Our findings demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice.