The genus Bassus Fabricius, 1804 (Hymenoptera: Braconidae: Agathidinae) in China,with description of three new species

Five species of Bassus Fabricius, are recognized to occur in China, of which three are new: Bassus guangxiensis sp. nov., Bassus levisulcus sp. nov. and Bassus robustus sp. nov. The new species are described and fully illustrated. Bassus albozonatus van Achterberg & Long, is recorded from China for the first time. A key to the Chinese species of the genus Bassus is provided.www.zoobank.org/urn:lsid:zoobank.org:pub:17297254-9E84-4D0F-AE8C-1F7264393137     

Does the miracle argument embody a base rate fallacy?

One way to reconstruct the miracle argument for scientific realism is to regard it as a statistical inference: since it is exceedingly unlikely that a false theory makes successful predictions, while it is rather likely that an approximately true theory is predictively successful, it is reasonable to infer that a predictively successful theory is at least approximately true. This reconstruction has led to the objection that the argument embodies a base rate fallacy: by focusing on successful theories one ignores the vast number of false theories some of which will be successful by mere chance.In this paper, I shall argue that the cogency of this objection depends on the explanandum of the miracle argument. It is cogent if what is to be explained is the success of a particular theory. If, however, the explanandum of the argument is the distribution of successful predictions among competing theories, the situation is different. Since the distribution of accidentally successful predictions is independent of the base rate, it is possible to assess the base rate by comparing this distribution to the empirically found distribution of successful predictions among competing theories.     

The genome of the model beetle and pest Tribolium castaneum

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.     

A recurrent mutation in PALB2 in Finnish cancer families

BRCA1, BRCA2 and other known susceptibility genes account for less than half of the detectable hereditary predisposition to breast cancer. Other relevant genes therefore remain to be discovered. Recently a new BRCA2-binding protein, PALB2, was identified. The BRCA2-PALB2 interaction is crucial for certain key BRCA2 DNA damage response functions as well as its tumour suppression activity. Here we show, by screening for PALB2 mutations in Finland that a frameshift mutation, c.1592delT, is present at significantly elevated frequency in familial breast cancer cases compared with ancestry-matched population controls. The truncated PALB2 protein caused by this mutation retained little BRCA2-binding capacity and was deficient in homologous recombination and crosslink repair. Further screening of c.1592delT in unselected breast cancer individuals revealed a roughly fourfold enrichment of this mutation in patients compared with controls. Most of the mutation-positive unselected cases had a familial pattern of disease development. In addition, one multigenerational prostate cancer family that segregated the c.1592delT truncation allele was observed. These results indicate that PALB2 is a breast cancer susceptibility gene that, in a suitably mutant form, may also contribute to familial prostate cancer development.     

随机模糊环境下企业动态生产计划编制

企业面对多变的内外部条件,处于动态、随机、模糊环境下。在这种环境下,企业如何决策自己的发展规划,制定合理的计划,并确保计划目标的实现,是一个关键的问题。应用多阶段决策理论,结合随机与模糊理论,构造了企业多阶段动态发展模型,建立了全状态转移矩阵,提出了随机熵权等概念,并对典型的动态发展与随机模糊企业系统--煤矿企业系统进行生产接续计划的编制,力争对多阶段决策理论和随机模糊理论的发展有所贡献。     

Two types of muscarinic acetylcholine receptors in Drosophila and other arthropods

Muscarinic acetylcholine receptors (mAChRs) play a central role in the mammalian nervous system. These receptors are G protein-coupled receptors (GPCRs), which are activated by the agonists acetylcholine and muscarine, and blocked by a variety of antagonists. Mammals have five mAChRs (m1–m5). In this study, we cloned two structurally related GPCRs from the fruit fly Drosophila melanogaster, which, after expression in Chinese hamster ovary cells, proved to be muscarinic acetylcholine receptors. One mAChR (the A-type; encoded by gene CG4356) is activated by acetylcholine (EC₅₀, 5 × 10^?8 M) and muscarine (EC₅₀, 6 × 10^?8 M) and blocked by the classical mAChR antagonists atropine, scopolamine, and 3-quinuclidinyl-benzilate (QNB), while the other (the B-type; encoded by gene CG7918) is also activated by acetylcholine, but has a 1,000-fold lower sensitivity to muscarine, and is not blocked by the antagonists. A- and B-type mAChRs were also cloned and functionally characterized from the red flour beetle Tribolium castaneum. Recently, Haga et al. (Nature 2012, 482: 547–551) published the crystal structure of the human m2 mAChR, revealing 14 amino acid residues forming the binding pocket for QNB. These residues are identical between the human m2 and the D. melanogaster and T. castaneum A-type mAChRs, while many of them are different between the human m2 and the B-type receptors. Using bioinformatics, one orthologue of the A-type and one of the B-type mAChRs could also be found in all other arthropods with a sequenced genome. Protostomes, such as arthropods, and deuterostomes, such as mammals and other vertebrates, belong to two evolutionarily distinct lineages of animal evolution that split about 700 million years ago. We found that animals that originated before this split, such as cnidarians (Hydra), had two A-type mAChRs. From these data we propose a model for the evolution of mAChRs.     

The Entropies Evaluation of the High-entropy System and its Determination of Operating Entropy

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