改进的支持向量机低分辨雷达目标分类算法

针对雷达目标识别系统中存在库外目标、各特征属性分类性能不一致,低分辨雷达不同类别目标特征值分布区间混叠的问题。文中基于支持向量机分类算法,对目标样本特征值进行置信度分析,获得置信区间,利用代价函数确定拒识门限,对库外目标以及混叠区域目标进行拒识分析;并根据训练样本先验识别率使用注水原理分配特征属性权重;在此基础上利用支持向量机进行目标识别。雷达实测数据实验结果表明,引入置信拒识分析与注水分配加权后,分类器性能得到了有效改善。     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.     

Test for Heteroscedasticity in Partially Linear Regression Models

Testing heteroscedasticity determines whether the regression model can predict the dependent variable consistently across all values of the explanatory variables. Since the proposed tests could not detect heteroscedasticity in all cases, more precisely in heavy-tailed distributions, the authors established new comprehensive test statistic based on Levene's test. The authors built the asymptotic normality of the test statistic under the null hypothesis of homoscedasticity based on the recent theory of analysis of variance for the infinite factors level. The proposed test uses the residuals from a regression model fit of the mean function with Levene's test to assess homogeneity of variance. Simulation studies show that our test yields better than other methods in almost all cases even if the variance is a nonlinear function. Finally, the proposed method is implemented through a real data-set.     

非线性光机械系统中的弱力探测

从理论上研究了包含光学参量放大器的非线性腔光机械系统的弱力探测性能.一方面,发现通过调节光学参量放大器的非线性增益以及输入光场与腔场之间的有效失谐,可以减小压缩正交中约14 dB的量子噪声,从而将弱力探测灵敏度提高2倍以上.另一方面,分析了非线性腔结合零差测量产生的反作用噪声相消现象并且实现量子非破坏测量的方法.     

Erratum to: Hesperomyces virescens (Fungi,Ascomycota, Laboulbeniales) attacking Harmonia axyridis (Coleoptera,Coccinellidae) in its native range

正Published online:14 March 2014óScience China Press and Springer-Verlag Berlin Heidelberg 2014Erratum to:Chin.Sci.Bull.(2014)59(5–6):528–532DOI 10.1007/s11434-013-0060-1In the original publication of this paper,the first name and the last name of the first author has been documented     

TRIZ理论在风电产品设计中的应用

介绍了TRIZ理论的产生及其理论体系,重点介绍了其在产品设计创新中应用最为广泛的TRIZ矛盾理论,包括矛盾的定义、分类及相关的解决原理,并结合实例说明了TRIZ理论的矛盾理论在风电产品设计中的应用及在企业中推广TRIZ理论的重要意义。