关于刚体绕定点运动几个问题的探讨

本文从一个新的角度讨论了定点运动刚体运动方程的建立,推导了角速度、角加速度及任一点的速度、加速度的计算公式,并且举例说明了各个公式的应用。     

颗粒-流体系统表观粘度和粒子群曳力系数的研究

利用RV20-M型转子粘度仪测定了玻璃珠-甘油体系的表观粘度,提出了体系表观粘度的关联式。并对单颗粒-流体系统的Re数和粒子的曳力系数进行修正,给出了一个适用于Re_m<2×10~5的多颗粒-液体系统中粒子曳力系数的关系式。     

三相流化床内不同空间位置压强脉动的特征分析

利用半导体应变片压力传感器。测定了不同操作条件下气-液-固三相流化床内不同轴向和径向位置压强的脉动信号。根据压强脉动信号波形和频域的分析结果,研究了三相流化床不同空间位置压强的脉动特征。发现在一定操作条件下,床层不同轴向位置上压强的脉动特征不同,而不同径向上压强的脉动特征则基本相似。     

资本市场中的头羊-从羊模型

针对目前中国证券市场中普遍存在着个人投资者对机构投资者的羊群行为这一特殊现象 ,建立了一个头羊 -从羊模型 .通过一定的参数假设和计算 ,定量地指出这种羊群行为增加了资产价格的波动 ,并且在大多数情况下头羊的收益大于从羊的收益 .但是随着头羊数量的增加和头羊收到的信息中的噪声增加 ,头羊 -从羊的收益之差减少 .最后从模型结论引申出稳定市场、改善市场结构、增加信息效率的建议.     

韩中“义狗说话”比较研究

韩国和中国民间,长期以来流播着大量的"义狗说话".对两国同类型故事的梳理和分析比较,可以发现韩国"义狗说话"既受到中国民间故事的影响,同时也在许多方面有着自己的独创性.     

Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis

The filamins are cytoplasmic proteins that regulate the structure and activity of the cytoskeleton by cross-linking actin into three-dimensional networks, linking the cell membrane to the cytoskeleton and serving as scaffolds on which intracellular signaling and protein trafficking pathways are organized (reviewed in refs. 1,2). We identified mutations in the gene encoding filamin B in four human skeletal disorders. We found homozygosity or compound heterozygosity with respect to stop-codon mutations in autosomal recessive spondylocarpotarsal syndrome (SCT, OMIM 272460) and missense mutations in individuals with autosomal dominant Larsen syndrome (OMIM 150250) and the perinatal lethal atelosteogenesis I and III phenotypes (AOI, OMIM 108720; AOIII, OMIM 108721). We found that filamin B is expressed in human growth plate chondrocytes and in the developing vertebral bodies in the mouse. These data indicate an unexpected role in vertebral segmentation, joint formation and endochondral ossification for this ubiquitously expressed cytoskeletal protein.     

A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac

With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout collection. The P-element transposon, the workhorse of D. melanogaster molecular genetics, has a pronounced nonrandom insertion spectrum. It has been estimated that 87% saturation of the approximately 13,500-gene complement of D. melanogaster might require generating and analyzing up to 150,000 insertions. We describe specific improvements to the lepidopteran transposon piggyBac and the P element that enabled us to tag and disrupt genes in D. melanogaster more efficiently. We generated over 29,000 inserts resulting in 53% gene saturation and a more diverse collection of phenotypically stronger insertional alleles. We found that piggyBac has distinct global and local gene-tagging behavior from that of P elements. Notably, piggyBac excisions from the germ line are nearly always precise, piggyBac does not share chromosomal hotspots associated with P and piggyBac is more effective at gene disruption because it lacks the P bias for insertion in 5' regulatory sequences.     

Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans

Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the gene FLNA, is a widely expressed protein that regulates re-organization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes and second messengers. We identified localized mutations in FLNA that conserve the reading frame and lead to a broad range of congenital malformations, affecting craniofacial structures, skeleton, brain, viscera and urogenital tract, in four X-linked human disorders: otopalatodigital syndrome types 1 (OPD1; OMIM 311300) and 2 (OPD2; OMIM 304120), frontometaphyseal dysplasia (FMD; OMIM 305620) and Melnick-Needles syndrome (MNS; OMIM 309350). Several mutations are recurrent, and all are clustered into four regions of the gene: the actin-binding domain and rod domain repeats 3, 10 and 14/15. Our findings contrast with previous observations that loss of function of FLNA is embryonic lethal in males but manifests in females as a localized neuronal migration disorder, called periventricular nodular heterotopia (PVNH; refs. 3-6). The patterns of mutation, X-chromosome inactivation and phenotypic manifestations in the newly described mutations indicate that they have gain-of-function effects, implicating filamin A in signaling pathways that mediate organogenesis in multiple systems during embryonic development.     

急性运动对血清氧自由基代谢水平影响的实验研究

本实验旨在观察急性运动后血清中氧自由基代谢水平的变化情况,本实验采用自身对照的方法,24名受试者于实验前和实验后各进行一次血清中MDA、SOD以及GSH-px的水平测试.运动方式为:以75%VO2max蹬功率自行车,持续1h.结果表明:急性较大强度运动后机体中产生了大量氧自由基,同时体内抗氧化酶的活性也明显增加,自由基生成与清除的动态平衡并未遭到破坏.     

有氧健身操对单纯性肥胖大学生心功能影响的实验研究

目的 探讨有氧健身运动对单纯性肥胖大学生心功能的影响;方法 选取西安工业大学25名单纯性肥胖男大学生,以有氧健身运动为原则,以心功能指标为评价系统,在安静状态下,采用MCA-4B心功测试系统测试单纯性肥胖男大学生有氧健身锻炼前后部分心功能指标;结果 有氧健身锻炼前后,心功能主要指标锻炼前后存在显著性差异;结论 有氧健身操可以很好地改善单纯性肥胖大学生的心功能.