Exact inference for two exponential populations with competing risks data

In a reliability comparative test, the joint censoring model is usually adopted to evaluate the performances of units with the same facility. However, most researchers ignore the pos- sibility that there is more than one factor for the failure when a test unit fails. To solve this problem, we consider a joint Type-II hybrid censoring model for the analysis of exponential competing failure data. Based on the maximum likelihood theory, we compute the maximum likelihood estimators （MLEs） of parameters and then obtain the condition ensuring MLEs existence for every unknown parameter. Then we derive the conditional exact distributions and corresponding moment properties for parameters by the moment generating function （MGF）. A Monte-Carlo simulation is conducted to compare the performances of different ways. And finally, we conduct a numerical example to illustrate the proposed method.     

1000 mm2 cross-section wire a led four tension exhibition put to traction practice

文章介绍了宁东一山东±660 kV直流输电示范工程(晋4标段)1 000 mm2大截面导线一牵四张力展放施工中,使用4个转向滑车转向布置牵引场的实践过程及施工中的注意事项.     

基于双层多粒子群算法的HDEHR系统资源分配

为解决集中式区域医疗信息集成系统存在的访问瓶颈问题,设计了一种层次化分布式EHR集成模型HDEHR(hierarchical distributed EHR).介绍了HDEHR模型的总体架构,指出了该模型中的系统资源分配问题.为HDEHR系统资源分配问题进行了形式化定义,提出一种采用平均等待时间和网络与节点资源利用均衡度的调和模型作为最优化目标函数.根据HDEHR模型层次化的特点设计了一种双层多粒子群算法BLMSPSO(bi-level multi-swarm PSO),并用其解决了模型资源的最优化分配问题.采用HDEHR-Sim仿真平台进行了试验,对HDEHR算法和集中式EHR模型进行了比较.结果表明,该系统具备线性响应能力,能很好地解决集中式EHR集成模型存在访问瓶颈的问题.     

支持风险投资的政策体系和制度设计研究

风险投资产业的蓬勃发展,需要政府部门的大力支持和推进。首先对现有国内外支持风险投资的政策进行了分析和评价,进而探讨了促进风险投资的制度设计。通过整合一系列的资源要素,形成系统化的制度环境,我国未来的风险投资产业将能够获得长足的发展。     

浅谈低价中标暴露的问题与对策

文章阐述了目前建筑市场实施最低价中标过程中暴露的问题,就如何更好地使用最低价中标法提出了一些自己的建设性建议.     

浅议如何提高煤炭运销企业员工的科学素质

目前,煤炭运销企业面临国内诸多新形势、新任务、新挑战,受到不确定因素的影响,企业科学发展着力需求一批有知识、懂业务、能力强、素质高的职工队伍,在企业建设中能够充分发挥群体作用,以便适应当前市场经济变幻莫测、企业形势此起彼伏的需求,亟待解决的是创建学习型企业,提高职工队伍素质,培养造就一支过硬的团队是煤炭运销企业又好又快科学发展的必要途径,也是建立健全现代化煤炭运销企业的基础保证.     

航空铝合金预腐蚀疲劳寿命退化规律

航空铝合金材料在服役过程中常因腐蚀损伤而导致疲劳断裂问题,通过采用扫描电镜及疲劳寿命测试等方法,研究了不同预腐蚀损伤对2xxx铝合金在不同应力比下疲劳寿命的影响,探讨了预腐蚀损伤对疲劳裂纹萌生扩展的影响机理.结果表明:预腐蚀损伤对2xxx铝合金材料疲劳寿命的影响显著,材料的疲劳性能随着腐蚀损伤程度的增加而明显下降.同时建立了预腐蚀损伤对材料疲劳极限的影响系数C-T-R模型,材料疲劳极限的影响系数C随着预腐蚀时间的增加或者应力比R的增加而变大.断口分析表明,预腐蚀损伤的存在导致裂纹萌生寿命大大缩短,裂纹萌生由单源转变为多源,并且均萌生于腐蚀坑处.     

Microstructure and properties of in-situ synthesized Cu-1 wt%TiC alloy followed by ECAP and post-annealing

A dispersion-strengthened copper alloy with 1 wt% TiC for commercial electrical-contact wires was prepared by in-situ reaction casting, grain-ultrafining by equal-channel angular pressing (ECAP) and subsequent annealing with aim to obtain excellent comprehensive performance. The results showed that fine TiC particles were in-situ synthesized in the as-cast Cu matrix and aggregated in clusters, and thus mechanical properties of the as-cast alloy deemed insufficient. Continued ECAP at 473 K significantly refined the grains of the as-cast alloy and improved the distribution of TiC particles. Due to multiple strengthening mechanisms, the ECAP-processed alloys maintained good conductivity with obviously enhanced tensile strength and hardness values. After post-ECAP annealing, the elongation and conductivity of the fine-grained copper alloy increased with the adequate tensile strength. The novel combined process endows the alloy appropriate performance to serve current high-frequency electrification railway systems.     

生化实验室在实践教学中的课程协调和管理作用

自2011年以来,为实现培养医学生动手能力、批判性思维和创新能力的教学目标,作为基础实验课程的生物化学与分子生物学实验在实验内容和课程设置方面进行了一系列的改革,循序渐进,由浅入深,同时突出小班化精英化的教育特色,最大限度地使学生受益。在整个课程的实施过程中,生物化学与分子生物学实验室作为实践课程开展的核心部门,无论是在课程准备,课程安排,还是在教学资源分配和课程内容改革中,都起到了有利的协调和管理作用,最大限度地服务于实践教学,使实验课程在良好有序的环境中发展前行。     

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

The CDKN2b-CDKN2a locus on chromosome 9p21 in human (chromosome 4 in mouse) is frequently lost in cancer. The locus encodes three cell cycle inhibitory proteins: p15INK4b encoded by CDKN2b, p16INK4a encoded by CDKN2a and p14ARF (p19Arf in mice) encoded by an alternative reading frame of CDKN2a (ref. 1). Whereas the tumour suppressor functions for p16INK4a and p14ARF have been firmly established, the role of p15INK4b remains ambiguous. However, many 9p21 deletions also remove CDKN2b, so we hypothesized a synergistic effect of the combined deficiency for p15INK4b, p14ARF and p16INK4a. Here we report that mice deficient for all three open reading frames (Cdkn2ab-/-) are more tumour-prone and develop a wider spectrum of tumours than Cdkn2a mutant mice, with a preponderance of skin tumours and soft tissue sarcomas (for example, mesothelioma) frequently composed of mixed cell types and often showing biphasic differentiation. Cdkn2ab-/- mouse embryonic fibroblasts (MEFs) are substantially more sensitive to oncogenic transformation than Cdkn2a mutant MEFs. Under conditions of stress, p15Ink4b protein levels are significantly elevated in MEFs deficient for p16Ink4a. Our data indicate that p15Ink4b can fulfil a critical backup function for p16Ink4a and provide an explanation for the frequent loss of the complete CDKN2b-CDKN2a locus in human tumours.