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1.
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response 总被引:4,自引:0,他引:4
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Conventional artificial fish has some shortages on the interaction with environment, other fish, and the animator. This article proposes a multi-tier interaction control model of artificial fish, realizes the interaction model through integration of virtual reality technology and Markov sequence, and provides a virtual marine world to describe the interaction between artificial fish and the virtual environment and the interaction between the artificial fish and the animator. Simulation results show that the interaction model owns not only the basic characteristics of virtual biology, but also has high trueness interaction function. 相似文献
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用类Lee-Low-Pines中间耦合方法讨论了在有限温度情形极性-极性半导体异质结中界面极化子的性质.在二维近似下,得到了两支界面光学声子模影响下的极化子能量和有效质量的解析表达式.结果表明:极化子效应随温度的升高而减弱,并发现极化子能量较其有效质量对温度更为敏感.数值结果表明温度效应对某些Ⅱ-Ⅵ族半导体异质结是重要的,但对Ⅲ-Ⅴ族半导体异质结是不重要的. 相似文献
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Cellular immune response is a major barrier to xenotransplantation. Human tumor necrosis factor-α (hTNF-α) possesses cross-species activity and directly amplifies the immune rejection via the upregulation of adhesion molecules on porcine endothelium. We investigated the role of protein tyrosine phosphorylation in the induction of expression of E-sclectin and vascular cell adhesion molecule-1 (VCAM-1), and the augmentation of adhesion of human peripheral blood monocytes (PBMo) and natural killer cells (PBNK), after rhTNF-α-stimulation of porcine aortic endothelial cells (PAEC) in vitro, rhTNF-α-increased adhesiveness of PAEC for both PBMo and PBNK was dose-dependently reduced by pretreatment of PAEC with the selective protein tyrosine kinase (PTK) inhibitor genistein. The inhibitory effect occurred at the early time of PAEC activation triggered by rhTNF-α, and was completely reversible. PTK activity assay indicated that genistein also suppressed rhTNF-α stimulated activation of protein tyrosine kinases (PTKs) in PAEC in a dose-dependent manner. Flow cytometric analysis showed that genistein inhibited the upregulation of E-selectin and VCAM-1 by rhTNF-α. These results suggest that PTKs may regulate the expression of E-selectin and VCAM-1 on PAEC and the adherence of PBMo and PBNK induced by rhTNF-α. Moreover, dietary genistein, used as an adhesion antagonist, may contribute to managing the cell-mediated rejection in the clinical application. 相似文献
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具有循环中心和小中心商的有限p群 总被引:3,自引:0,他引:3
本文证明中心循环且中心商为p~5阶群的有限p群能分为15个互不同构的类。 相似文献
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Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins 总被引:1,自引:0,他引:1
During protein biosynthesis, nascent polypeptide chains that emerge from the ribosomal exit tunnel encounter ribosome-associated chaperones, which assist their folding to the native state. Here we present a 2.7 A crystal structure of Escherichia coli trigger factor, the best-characterized chaperone of this type, together with the structure of its ribosome-binding domain in complex with the Haloarcula marismortui large ribosomal subunit. Trigger factor adopts a unique conformation resembling a crouching dragon with separated domains forming the amino-terminal ribosome-binding 'tail', the peptidyl-prolyl isomerase 'head', the carboxy-terminal 'arms' and connecting regions building up the 'back'. From its attachment point on the ribosome, trigger factor projects the extended domains over the exit of the ribosomal tunnel, creating a protected folding space where nascent polypeptides may be shielded from proteases and aggregation. This study sheds new light on our understanding of co-translational protein folding, and suggests an unexpected mechanism of action for ribosome-associated chaperones. 相似文献
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<正>Introduction In recent years the production of aluminum alloy has leaped to second place in overall metal material pro-duction, surpassed only by steel. In addition to use in the aviation industry, aluminum alloy has begun to be applied in the machinery manufacturing industry and 相似文献
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采用固相微萃取(SPME)技术,气质联用(GC-MS)法分析野生和栽培铁皮石斛的挥发性成分.从野生和栽培铁皮石斛中,分别鉴定出97种和80种挥发性成分,相对含量均占总离子峰的96.0%,具有60个相同的化合物,主要成分均包含芳樟醇、癸醛、对映-海松-8(14),15-二烯等化合物. 相似文献