排序方式: 共有6条查询结果,搜索用时 15 毫秒
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Y Okada X Sim MJ Go JY Wu D Gu F Takeuchi A Takahashi S Maeda T Tsunoda P Chen SC Lim TY Wong J Liu TL Young T Aung M Seielstad YY Teo YJ Kim JY Lee BG Han D Kang CH Chen FJ Tsai LC Chang SJ Fann H Mei DC Rao JE Hixson S Chen T Katsuya M Isono T Ogihara JC Chambers W Zhang JS Kooner;KidneyGen Consortium;CKDGen Consortium E Albrecht;GUGC consortium K Yamamoto M Kubo Y Nakamura N Kamatani N Kato J He YT Chen YS Cho ES Tai T Tanaka 《Nature genetics》2012,44(8):904-909
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ~110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function. 相似文献
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The present research brings new insights on the role of admixed corrosion inhibitors in the processes of cement hydration and rebar corrosion.The admixing of NaCl and the corrosion inhibitors in fresh mortar was found to alter the morphology and microstructure of the hardened mortar at the steel-mortar interfacial region.The admixing of the inhibitors increased the risk of carbonation of cement hydrates at the steel-mortar interfacial region,but partially displaced chloride ions. Chloride and the admixed in... 相似文献
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Nejentsev S Thye T Szeszko JS Stevens H Balabanova Y Chinbuah AM Hibberd M van de Vosse E Alisjahbana B van Crevel R Ottenhoff TH Png E Drobniewski F Todd JA Seielstad M Horstmann RD 《Nature genetics》2008,40(3):261-2; author reply 262-3
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Kato N Takeuchi F Tabara Y Kelly TN Go MJ Sim X Tay WT Chen CH Zhang Y Yamamoto K Katsuya T Yokota M Kim YJ Ong RT Nabika T Gu D Chang LC Kokubo Y Huang W Ohnaka K Yamori Y Nakashima E Jaquish CE Lee JY Seielstad M Isono M Hixson JE Chen YT Miki T Zhou X Sugiyama T Jeon JP Liu JJ Takayanagi R Kim SS Aung T Sung YJ Zhang X Wong TY Han BG Kobayashi S Ogihara T Zhu D Iwai N Wu JY Teo YY Tai ES Cho YS He J 《Nature genetics》2011,43(6):531-538
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention. 相似文献
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Y chromosome sequence variation and the history of human populations 总被引:48,自引:0,他引:48
Underhill PA Shen P Lin AA Jin L Passarino G Yang WH Kauffman E Bonné-Tamir B Bertranpetit J Francalacci P Ibrahim M Jenkins T Kidd JR Mehdi SQ Seielstad MT Wells RS Piazza A Davis RW Feldman MW Cavalli-Sforza LL Oefner PJ 《Nature genetics》2000,26(3):358-361
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago. 相似文献
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