排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
Elia J Glessner JT Wang K Takahashi N Shtir CJ Hadley D Sleiman PM Zhang H Kim CE Robison R Lyon GJ Flory JH Bradfield JP Imielinski M Hou C Frackelton EC Chiavacci RM Sakurai T Rabin C Middleton FA Thomas KA Garris M Mentch F Freitag CM Steinhausen HC Todorov AA Reif A Rothenberger A Franke B Mick EO Roeyers H Buitelaar J Lesch KP Banaschewski T Ebstein RP Mulas F Oades RD Sergeant J Sonuga-Barke E Renner TJ Romanos M Romanos J Warnke A Walitza S Meyer J Pálmason H Seitz C Loo SK Smalley SL 《Nature genetics》2012,44(1):78-84
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10(-9)). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 × 10(-6)). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ~10% of the cases (P = 4.38 × 10(-10)) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts. 相似文献
2.
W. J. Rietveld F. ten Hoor M. Kooij W. Flory 《Cellular and molecular life sciences : CMLS》1979,35(10):1334-1336
Summary A method is described in which food approach behaviour of rats is recorded to study feeding behaviour. Between rats, differences in food approach behaviour were observed. For each rat, food approach behaviour was constant over a long period of time. This allows conversion of approach behaviour data into quantified feeding behaviour. Examples of long-term feeding behaviour and of reproducibility of food intake are given. 相似文献
3.
4.
A method is described in which food approach behaviour of rats is recorded to study feeding behaviour. Between rats, differences in food approach behaviour were observed. For each rat, food approach behaviour was constant over a long period of time. This allows conversion of approach behaviour data into quantified feeding behaviour. Examples of long-term feeding behaviour and of reproducibility of food intake are given. 相似文献
1