Aided and unaided decision making: Improving intuitive judgement

Intuitive judgement forms the basis of decision making both by experts, in professional settings, and by people in everyday life. Psychologists have studied the rationality of intuitive judgements. In this paper three approaches to decision making will be discussed: unqualified rationalism, qualified rationalism and irrationalism. The first approach holds that man is essentially rational, the second that serious cognitive biases exist, and the third that thinking is strongly influenced by non-cognitive sources of distortion, i.e. emotions and motives. Evidence on judgement is reviewed and found to support the last two approaches. Various ways of improving judgements, as suggested by the three basic viewpoints, are then presented.     

全球化与新的教育政策——欧洲高等教育面临的新挑战

社会的加速变化导致欧洲新教育政策的出台,里斯本战略提出了欧盟教育系统未来要实现的目标,即把欧盟建设成为世界上最具竞争力和多样性的知识经济体,高等教育在其中扮演着越来越重要的角色。分析过去10年欧洲颁布的相关政策文本可以发现,国家、市场和公民社会都对大学产生了新的期望,技术、经济和政治对劳动力市场以及大学的影响也越来越大。在全球化时代,大学应该建立起国际网络以促进国际合作、交流与竞争。     

A network dysfunction perspective on neurodegenerative diseases

Patients with Alzheimer's disease or other neurodegenerative disorders show remarkable fluctuations in neurological functions, even during the same day. These fluctuations cannot be caused by sudden loss or gain of nerve cells. Instead, it is likely that they reflect variations in the activity of neural networks and, perhaps, chronic intoxication by abnormal proteins that the brain is temporarily able to overcome. These ideas have far-reaching therapeutic implications.     

Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

A common viral immune evasion strategy involves mutating viral surface proteins in order to evade host neutralizing antibodies. Such immune evasion tactics have not previously been intentionally applied to the development of novel viral gene delivery vectors that overcome the critical problem of anti-vector immunity. Recombinant, replication-incompetent adenovirus serotype 5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 and other pathogens have proved highly immunogenic in preclinical studies but will probably be limited by the high prevalence of pre-existing anti-Ad5 immunity in human populations, particularly in the developing world. Here we show that rAd5 vectors can be engineered to circumvent anti-Ad5 immunity. We constructed novel chimaeric rAd5 vectors in which the seven short hypervariable regions (HVRs) on the surface of the Ad5 hexon protein were replaced with the corresponding HVRs from the rare adenovirus serotype Ad48. These HVR-chimaeric rAd5 vectors were produced at high titres and were stable through serial passages in vitro. HVR-chimaeric rAd5 vectors expressing simian immunodeficiency virus Gag proved comparably immunogenic to parental rAd5 vectors in naive mice and rhesus monkeys. In the presence of high levels of pre-existing anti-Ad5 immunity, the immunogenicity of HVR-chimaeric rAd5 vectors was not detectably suppressed, whereas the immunogenicity of parental rAd5 vectors was abrogated. These data demonstrate that functionally relevant Ad5-specific neutralizing antibodies are focused on epitopes located within the hexon HVRs. Moreover, these studies show that recombinant viral vectors can be engineered to circumvent pre-existing anti-vector immunity by removing key neutralizing epitopes on the surface of viral capsid proteins. Such chimaeric viral vectors may have important practical implications for vaccination and gene therapy.