Aggression in mice associated with changes in the monoamine-metabolism of the brain

Zusammenfassung MitHerpes simplex Virus i.c. beimpfte Mäuse entwickelten nach vorausgegangener Behandlung mitp-Chlorphenylalanin ein ausgesprochen aggressives Verhalten. Bei Mäusen, deren Serotoninsynthese durch Behandlung mitp-Chlorphenylalanin oder-Propylacetamid ausser Funktion gesetzt war, konnte ausgeprägtes Aggressionsverhalten durch i.p. Injektion vonl-DOPA induziert werden.     

Effect of cortisone or triiodothyronine administration to pregnant rats on lysosomal hydrolases in fetal forebrain and cerebellum

Triiodothyronine injected daily to pregnant rats for the last week of gestation (50 microgram/100 g b.wt) increased the specific activities of 5 acid glycosidases in the fetal forebrain and cerebellum. Cortisone (50 mg/100 g b.wt) administered in the same period had no effect on cerebellum acid hydrolases, but decreased their activity in the forebrain.     

Effect of cortisone or triiodothyronine administration to pregnant rats on lysosomal hydrolases in fetal forebrain and cerebellum

Summary Triiodothyronine injected daily to pregnant rats for the last week of gestation (50 g/100 g b.wt) increased the specific activities of 5 acid glycosidases in the fetal forebrain and cerebellum. Cortisone (50 mg/100 g b.wt) administered in the same period had no effect on cerebellum acid hydrolases, but decreased their activity in the forebrain.Supported by grant No. HD 08536 from the National Institutes of Health, Bethesda, Maryland.     

Characteristic changes of cerebellar proteins associated with cerebellar hypoplasia in jaundiced Gunn rats and the prevention of these by phototherapy

Summary In the cerebellar particulate fractions from Gunn rat homozygotes 3 protein bands with apparent mol.wts of 250,000, 50,000 and 33,000 in SDS-polyacrylamide gel disc electrophoresis underwent major changes, and phototherapy of the newborns could effectively prevent the changes.A part of this research was supported by grants from the Ministry of Education in Japan (No.448131) and the Japan Association for Maternal Welfare.     

The action of cortisone on the embryonic cartilage and musclein vitro

Zusammenfassung Cortison verzögert das Wachstum von embryonalen Femur-Anlagen und hemmt die hypertrophische Entwicklung des Knorpelsin vitro, fördert aber die Differenzierung der gestreiften Myoblasten.     

Interconversion of cortisol and cortisone in theMacaca mulatta

Zusammenfassung Die Umwandlung von Kortisol in Kortison und umgekehrt wird nach Injektion von radioaktiven Steroiden bei einem weiblichen Affen (Macaca mulatta) untersucht. Es konnte festgestellt werden, dass im Blut Kortisol relativ rasch in Kortison umgewandelt wurde, während umgekehrt Kortison wesentlich langsamer umgewandelt wird.     

Orotic acid prevents changes in cardiac sarcolemmal glycoproteins and contractility associated with muscular dystrophy in hamsters

Summary Orotic acid included in the diet of cardiomyopathic hamsters during the myolytic phase of the disease (30–60 days of age) prevented the reduction in cardiac sarcolemmal sialic acid, calcium binding, sialyltransferase activity and contractile activity associated with the cardiomyopathy.This work was supported by research grants from the MRC of Canada, the Muscular Dystrophy Association of Canada and the Nova Scotia Heart Foundation. I thank Dr Peter E. Dresel for his encouragement and Ms Jane Benjamin and Mr Steven Couban for their technical assistance.     

Activities of kidney decarboxylases of histidine and ornithine in adrenalectomized mice substituted with cortisone.

In adrenalectomized mice, cortisone inhibited histidine decarboxylase of the kidney in a dose-related manner. The effect of cortisone on ornithine decarboxylase was diphasic: small doses elevated, high doses inhibited.     

Lack of cortisone inhibition of chromosomal puffing inDrosophila melanogaster

Résumé L'administration de cortisone (ou d'hydrocortisone) à des larvesDrosophila n'inhibe pas le bourgeonnement normal des chromosomes de leurs glandes salivaires. Toutefois, la quantité de cortisone que ces larves peuvent tolérer est environ 1/10 de celle qui supprime le bourgeonnement chez les larvesSciara.