IRF7表达与系统性红斑狼疮的相关性

探讨了干扰素调节因子7(IRF7)的表达与中国汉族人群系统性红斑狼疮(SLE)的相关性.运用实时荧光定量聚合酶链式反应的方法分别测定疾病患者与正常对照组外周血IRF7mRNA的表达水平,并与血清中干扰素水平、干扰素积分以及SLEDAI积分作相关性分析.结果发现,患者外周血IRF7mRNA的表达水平较正常对照组的明显增高,且其与血清中干扰素水平、干扰素积分以及SLEDAI积分均呈正相关.由此可知,IRF7表达的增高可能促使干扰素通路异常激活,从而导致系统性红斑狼疮的发生.     

小剂量短波紫外线加超短波治疗系统性红斑狼疮患者带状疱疹感染

目的:观察小剂量短波紫外线加超短波治疗系统性红斑狼疮(SLE)患者带状疱疹感染的疗效及安全性.方法:30例患者随机分为两组,治疗组采用小剂量短波紫外线加超短波治疗,对照组单独采用口服阿昔洛韦片与外涂阿昔洛韦软膏治疗.结果:治疗组有效率高于对照组(均P<0.05),其止痛、止疱、结痂时间、总病程比对照组明显缩短(P<0.01),带状疱疹后遗神经痛发生率比对照组明显减少(P<0.05),治疗组治疗前后SLE活动性未发生明显改变(P>0.05).结论:小剂量短波紫外线加超短波治疗SLE患者带状疱疹感染疗效高,病程缩短,可减少后遗神经痛的发生率,且未增加SLE的活动性.     

系统性红斑狼疮尸检临床病理分析

目的：本文对３例系统性红斑狼疮（ＳＬＥ）尸检材料进行临床病理分析。探讨ＳＬＥ患者的继发感染和死因。方法：对ＳＬＥ尸检标本进行常规染色,光镜观察。结果：病变主要在肾脏、心内膜和浆膜,其他器官也可受到影响,而狼疮性肾炎是很明显。结论：ＳＬＥ属自身免疫性疾病。继发感染与使用皮质激素和免疫抑制剂有关。肾功衰竭是ＳＬＥ的死亡原因。     

系统性红斑狼疮与妊娠（综述）

系统性红斑狼疮（SLE）是累及全身多个系统的自身免疫性疾病,其对妊娠及胎儿发育均可产生不良影响。因此,妊娠期监护、风险预测及处理是SLE妇女安全过度过妊娠期的关键。     

Functional modifications of cytotoxic T-lymphocyte T200 glycoprotein recognized by monoclonal antibodies

Plasma membrane glycoproteins of cytotoxic T lymphocytes (CTLs) are involved in the binding to and subsequent destruction of appropriate target cells. The electrophoretic profile of surface proteins of mature CTLs, particularly those of high relative molecular mass (Mr), is markedly different from that of naive peripheral T cells or non-cytolytic T cells, suggesting the possible involvement of these molecules in the activation of CTLs and/or in the lytic process itself. By generating monoclonal antibodies to cell-surface proteins of CTL clones, we have now detected CTL-specific modifications in one of these high-Mr membrane proteins, T200. Although forms of T200 are found on a wide variety of cell types, the neoantigenic determinants recognized by our antibodies are present exclusively on activated T cells and in high concentrations only on CTLs. Furthermore, the expression of the modifications recognized by our antibodies is influenced by soluble factors and also seems to have functional significance, as monoclonal antibodies specific for these novel epitopes block cytolytic activity.     

HIV-specific cytotoxic T lymphocytes in seropositive individuals

Virus-specific cytotoxic T lymphocytes (CTL) which kill virus-infected cells are thought to be a major host defence against viral infections. Here we report the existence of human immunodeficiency virus (HIV)-specific CTL in persons infected with this virus, the aetiological agent of AIDS (acquired immunodeficiency syndrome). Recombinant HIV-vaccinia viruses were used to express HIV antigens in B-cell lines established from subjects seropositive for HIV and seronegative controls. Circulating lymphocytes capable of killing HIV env-expressing autologous B cells were detected in eight of eight seropositive subjects; in addition, at least three seropositive subjects demonstrated gag-specific cytotoxic responses. No HIV-specific cytotoxicity was observed in seronegative subjects. Selective inhibition of the env-specific cytotoxicity by a CD3-specific monoclonal antibody indicates that the effectors are T cells. This demonstration of a cytotoxic T-cell immune response to HIV in infected individuals should prove useful in investigating the immunopathogenesis of HIV infection further and in evaluating AIDS vaccine strategies.