Extracting the Cores of Implicit Communities

In this paper, we improve the trawling and point out some communities missed by trawling. We use the DBG （Dense Bipartite Graph） to identify a structure of a potential community instead of CBG （Complete Bipartite Graph）. Based on DBG, we proposed a new method based on edge removal to extract cores from a web graph. Moreover, we improve the crawler to save only potential pages as fans of a core and save a lot of disk storage space. To evaluate the set of cores whether or not belong to a community, the statistics of term frequency is used. In the paper, the dataset of experiment were crawled under domain ＂.cn＂. The result show that the our algorithm works properly and some new cores can be found by our method.     

Oligomerization study of NHR3 and NHR4 domains from ETO protein involved in t（8;21）-associated acute myeloid leukemia

Little had been known about ETO protein until t(8;21) was found in 12%-15% of acute myeloid leukemia which resulted in AML1-ETO fusion protein. ETO protein has four conserved nervy homology regions termed NHR1-4. A lot have already been known about NHR1, 2, 4:NHR1 is homologous with the Drosophila TATA-box-associated factor 110 (TAF110); NHR2 is a dimerization domain associated with mSin3A/HDAC; NHR4 is MYND class of zinc fingers associated with NCoR/SMRT/HDAC. Only the function of NHR3 remains unclear. In order to investigate whether NHR3 domain could participate in oligomerization, we cloned and purified this domain. Through gel filtration chromatography, dynamic light scattering and dissolved crystal electrophoresis, we found that NHR3 domain was a tight tetramer. Then we cloned NHR3 4 domain (i.e. NHR3 domain plus NHR4 domain), and discovered, by gel filtration chromatography and native PAGE, that NHR3 4 domaincould form dimer in solution. This was the first time to observe that NHR3 and NHR4 domains may have some contribution to the oligomerization of ETO protein, which might recruit corepressors in the form of dimer, and stabilize ETO dimerization through convergent strength of NHR2, NHR3 and NHR4 domains and then stabilize corepressors recruitment. These speculations are very worthy of further evaluation.     

Analytical Criteria for Local Activity of CNN with Two-port and Application to Biochemical Model

The analytic criteria are presented for the local activity theory in two-port Cellular Neural Network (CNN) cells with three local state variables, and the application to a Biochemical Model CNN (BMCNN) is given for coupling in series of two enzymes whose prototype was studied by Decroly and Goldbeter. The bifurcation diagrams of the BMCNN's show that there does not exist a locally passive domain, and the computer simulation exhibited that convergent patterns, oscillatory patterns or chaotic patterns may emerge if the selected cell parameters are located in locally active unstable domains but nearby the edge of chaos domain. In particular, the coexistence of multiple oscillations was observed in the corresponding triple cell couples of the BMCNN's with the same initial conditions.     

The entropy characters of point mutation

The biological diversity, which depends on the genetic material DNA, is the foundation for a species to survive and evolve. The entropy is the best measurement of biological diversity. Based on the single-parameter and the two-parameter models, here we established some differential equations about the point mutation of a DNA sequence with finite length, as well as some functions describing the processes of the variation in quantities of 4 kinds of bases （A, T, G and C） in the DNA sequence. At the molecular level, we discussed the entropy characteristics of point mutation. The results proved that a species maintained its entropy and evolved in the direction of the increasing biological diversity. In order to testify the theoretical results, we did a series of computer simulations of random point mutation in Matlab environment. The results were well consistent with the theoretical researches.     

THE ONE-SIDED HANDAMARD PRINCIPAL VALUE FOR SINGULAR-INTEGRALS OF HIGH ORDER AND ITS APPLICATIONS

0 IntroductionLet L = ab be a non-closed smooth arc oriented from a to b, t∈ L, t≠a,b, be the fixed point, andf(t) ∈H. (L) . The usual Hadamard principal value is defined asAbout properties and applications of singular integals of high order were investigated by many authors([1],[2],[3] etc. ) In 1987, the concepts of Hadamard principal value at one-side for singular integralsof high order and the rules of their differentiation are introduced [4]. In this paper we established the rulesof substitution of variable for one-sided Hadamard principal value of singular integrals of high order, andthen, we gave some applications in evaluation of real definite integrals.     

BLOW UP POINT SET OF POSITIVE SOLUTION FOR NONLINEAR HEAT EQUATION

In this paper we consider a class nonlinear heat equation, with non-local term and study that the structure of blow up point set of positive solution of initial boundary value problem in nonsymmatric convex domain.     

Centralized Role-Based Access Control for Federated Multi-Domain Environments

The secure interaction among multiple security domains is a major concern. In this paper, we highlight the issues of secure interoperability among multiple security domains operating under the widely accepted Role Based Access Control （RBAC） model. We propose a model called CRBAC that easily establishes a global policy for roles mapping among multiple security domains. Our model is based on an extension of the RBAC model. Also, multiple security domains were composed to one abstract security domain. Also roles in the multiple domains are translated to permissions of roles in the abstract security domain. These permissions keep theirs hierarchies. The roles in the abstract security domain implement roles mapping among the multiple security domains. Then, authorized users of any security domain can transparently access resources in the multiple domains.     

An efficient format-preserving encryption mode for practical domains

Format-preserving encryption (FPE), which makes sure that ciphertext has the same format as plaintext, has been widely used in protecting sensitive data in a database. Aiming at efficiently solving the FPE problem on a collection of practical domains, we propose the RREM (random reference-based encryption mode), which constructs bijection between the original domain and integer set through distance computation. If an appropriate distance function is predefined, the proposed mode can solve the FPE problem on linear equidistance domain in a more efficient way than previous methods. Furthermore, we make a classification on various types of domains, show the application of RREM in some practical domains, and specify RREM’s capability of solving the FPE problem on frequently-used fields in database quite efficiently.     

Clustering approach based on hierarchical expansion for community detection of scientific collaboration network①

This study presents a clustering algorithm based on hierarchical expansion to solve the problem of community detection in scientific collaboration network .The characteristics of achievements infor-mation related to scientific and technological domains are analyzed , and then an ontology that repre-sents their latent collaborative relations is built to detect clusters from the collaboration network .A case study is conducted to collect a data set of research achievements in the electric vehicle field and better clustering results are obtained .A hierarchical recommendation framework that enriches the domain ontologies and retrieves more relevant information resources is proposed in the last part of this paper .This work also lays out a novel insight into the exploitation of scientific collaboration net-work to better classify achievements information .     

Effect of conformation on UV-Vis absorption spectra of disazo reactive red dyes

In this study,twenty disazo reactive red dyes with J acid as coupling components were selected,and their ground state geometry were studied with BLYP functional and TZVP basis set. The UV-vis absorption spectra were calculated by time-dependent density functional theory(TDDFT) employing B3 LYP and PBE0 hybrid functionals and TZVP basis set,and the absolute mean errors are 0.094 e V and 0.133 e V for B3 LYP and PBE0,respectively. From the comparison of the calculated λ_(max) of the three conformations of disazo reactive red dye,cis-,trans-,and azo,with that of experimental one,we find out that conformation plays an important role on UV-Vis absorption. Dyes 6 and 8 exist in azo conformation rather than in cis-conformation. "Hole-electron" distribution analysis reveals that although these λ_(max) arises from different electron transitions,these electron excitations have the same character of local excitation(LE).     

Duplication and Combination of P-Loop Containing Nucleotide Triphosphate Hydrolases Superfamily

In a genome the set of proteins are formed by duplication and combination of domain superfamilies. P-loop containing nucleotide triphosphate （NTP） hydrolases superfamily is massively duplicated and has the most different partner superfamilies among archaea, bacteria and eukarya, Here, we study the distributions of duplication and combination of p-loop containing NTP hydrolases superfamily in 169 completed genomes. When the total number of domains in a genome is larger, duplication and combination partners of p-loop conraining NTP hydrolases are more. This phenomenon is more obvious in metazoa. The distributions of abundance and corn bination of partners relate to the functions of the protein. Those distributions in metazoa are very different from those in other kingdoms because of complexity of metazoa. Finally the relationship between duplication and combination of p-loop containing NTP hydrolases superfamily in different genomes is described. It fits a power law.     

An analytical model for the prediction of cross-section profile and mean roll radius in alloy bar rolling

In a round-oval-round pass rolling sequence, the cross-section profile of an outgoing workpiece was predicted first after getting the maximum spread. The concept "critical point on the contact boundary" was proposed and the coordinates of the critical point were solved. The equivalent contact section area was represented and the mean roll radius was determined. The validity of this model was examined by alloy bar rolling experiment and rigid-plastic FEM simulation. Compared with the existing models, the mean roll radius obtained by this model is similar to experiment data.     

PX domain and CD domain play different roles in localization and vacuolation of Sorting Nexin 10

Sorting nexins （SNXs） are PX domain containing proteins and essential for intracellular protein sorting, trafficking and signal transduction. The PX domains of SNXs can bind to various phosphorelated phosphoinositides （PIs） and target the host proteins to endosomes. Recently, we have reported that overexpression of SNX10 in mammalian cells could induce giant vacuoles. In this study, we aimed to identify regions in SNX10 critical for the vacuolation activity. We found that both the PX domain and the CD1 region were essential for vacuolation. We provided evidence that the PX domain was able to specifically bind to Ptdlns（3）P and target SNX10 to endosomes. A mutation in the 131 region of the PX domain （V15A） disrupted the Ptdlns（3）P binding ability and the endosomal localization of SNX10. However, correct subcellular localization alone was not sufficient for SNX10 to induce vacuoles. We found that the CD1 region, which was not required for the localization, was indispensable for the vacuolation activity of SNX10. In summary, both the PX domain and the CD1 region are necessary for SNX10 to induce vacuoles but they play different roles in this process.     

The specific contribution of object''''s origin on artifacts categorization

Gelman and Bloom found that adults and children's object naming was sensitive to how an object was created (man-made or not), but they did not reveal on which specific level of conceptual system this effect was. Using a free-naming task and a force-choice task, two experiments were conducted to test a hypothesis that this effect was specifically on domain level ("artifact/non-artifact" distinction). In Experiment 1, participants were asked to name shortly-depicted objects, rate their confidence, and report their reasons for each naming response. Results showed that most of the naming responses in "man-made" condition were in artifact domain, and most in "natural" condition were in non-artifact domain, although in both conditions names were very divergent on basic level. In Experiment 2, another group of participants were asked to choose one from two names (one in artifact domain and the other in non-artifact domain) to match the same shortly-depicted objects presented in the first experiment. Re-sults of Experiment 1 on domain level were replicated in Experiment 2. These convergent findings supported the hypothesis that the effect of object's origin is specifically on domain level of conceptual system of objects. Reasons explicitly reported for naming responses in Experiment 1 suggested that participants might automatically infer objects' functions in "man-made" condition but not in "natural" condition. Here the function-based hypothesis of artifacts classification is discussed.     

A preliminary study on functional domains of small heat shock protein Hsp16.3

Hsp16.3, the small heat shock protein (sHSP) from Mycobacterium tuberculosis, was originally identified as an immunodominant antigen,which possesses three functional domains typical of sHSP family, namely the N-terminal hydrophobic region, α-crystallin domain and a short non-conserved C-terminal extension.To further understand the functional assignment of these independent regions, the three functional domains of Hsp16.3 were defined and the two N- or C-terminal truncated Hsp16.3 remnants were successfully cloned, expressed and purified.In the far and near circular dichroism analysis, the results showed that these remnants expressed similar secondary and tertiary structures to that of wild-type protein.During the reassembly of wild-type nonamer, the C-terminal truncated remnant could interact with the wild-type protein to form hetero-oligomers.When trypsin is used to digest the wild-type Hsp16.3, its α-crystallin domain could resist such degradation.Taken together, these results indicate that the stable secondary and tertiary structures of Hsp16.3 are mainly kept by its α-crystallin domain.     

A FeNiMnC alloy with strain glass transition

Recent experimental and theoretical investigations suggested that doping sufficient point defects into a normal ferroelastic/martensitic alloy systems could lead to a frozen disordered state of local lattice strains(nanomartensite domains), thereby suppressing the long-range strain-ordering martensitic transition. In this study, we attempt to explore the possibility of developing novel ferrous Elinvar alloys by replacing nickel with carbon and manganese as dopant species. A nominal Fe_(89)Ni_5Mn_(4.6)C_(1.4) alloy was prepared by argon arc melting, and XRD, DSC, DMA and TEM techniques were employed to characterize the strain glass transition signatures, such as invariance in average structure, frequency dispersion in dynamic mechanical properties(storage modulus and internal friction) and the formation of nanosized strain domains. It is indicated that doping of Ni, Mn and C suppresses γ→α long-range strain-ordering martensitic transformation in Fe_(89)Ni_5Mn_(4.6)C_(1.4) alloy, generating randomly distributed nanosized domains by strain glass transition.     

Weighted LBF for spaceborne general bistatic SAR processing

Loffeld＇s bistatic formula （LBF） is the first two-dimensional analytic point target reference spectrum derived for general bistatic SAR frequency domain focusing. The phase history is expanded in Taylor series around the individual points of stationary phase of the trans- mitter-target and target-receiver phase histories, respectively, and thus the common bistatic stationary phase point can be obtained using the method of stationary phase. Unfortunately, it shows limitations for extreme bistatic configurations, namely the highly squinted mode and space-surface application. The weighted LBF （WLBF） is proposed in this paper based on the different contributions of total phase modulation from the transmitter and receiver. The formulae we derived are compared with that of the original literature. The extreme bistatic stripmap SAR data can be focused using WLBF, which accommodates the spaceborne squint geometry using the modified effective velocity solution. A point target simulation example is presented to verify the accuracy of the new WLBF spectrum.     

Parameterization for fitting triangular mesh

In recent years, with the development of 3D data acquisition equipments, the study on reverse engineering has become more and more important. However, the existing methods for parameterization can hardly ensure that the parametric domain is rectangular, and the parametric curve grid is regular. In order to overcome these limitations, we present a novel method for parameterization of triangular meshes in this paper. The basic idea is twofold: first, because the isotherms in the steady temperature do not intersect with each other, and are distributed uniformly, no singularity (fold-over) exists in the parameterization; second, a 3D harmonic equation is solved by the finite element method to obtain the steady temperature field on a 2D triangular mesh surface with four boundaries. Therefore, our proposed method avoids the embarrassment that it is impossible to solve the 2D quasi-harmonic equation on the 2D triangular mesh without the parametric values at mesh vertices. Furthermore, the isotherms on the temperature field are taken as a set of iso-parametric curves on the triangular mesh surface. The other set of iso-parametric curves can be obtained by connecting the points with the same chord-length on the isotherms sequentially. The obtained parametric curve grid is regular, and distributed uniformly, and can map the triangular mesh surface to the unit square domain with boundaries of mesh surface to boundaries of parametric domain, which ensures that the triangular mesh surface or point cloud can be fitted with the NURBS surface.     

Characterization of the separate kinase domain of chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

The bifunctional enzvme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase consists of two dis tinct domains which catalyze the synthesis and hydrolysis of fructose-2, 6-bisphosphate, respectively. In this work the properties of the separate 6-phosphofructo-2-kinase domain were investigated. Purification of the expressed separate do main or isolation of this domain from purified glutathione S-transferase (GST) fusion protein with thrombin cleavage led to the loss of its kinase activity. Thus the domain in the GST-tagged form was characterized. The two forms of the do main with different lengths (amino acids 1 ～ 249 and 1 ～ 286) were very similar in kinetic property and could catalyze the formation of fructose-2,6-bisphosphate with a kcat 4-fold lower than that of the full-length enzyme. In addition, the domain was much more sensitive to guanidine inactivation and heat denaturation, and less stable at pH values below 7 than the full-length enzyme. The results suggest that the separate kinase domain of the bifunctional enzyme is far less perfect in structure in the absence of the bisphosphatase domain, though it still possesses the 6-phosphofructo-2-kinase activity.     

Effect of charge on growth of droplets with ionic condensation nuclei

A growth kinetics model of droplets with ionic condensation nuclei based on the chemical potential and the kinetic equation of mass transfer is established. The model is simplified and the effect of charge on droplet growth is examined. The theoretical results show that the critical radius for droplet growth with an ionic condensation nucleus is less than that of those without an ionic nucleus. Furthermore, our results also indicate that if the initial droplet with an ionic nucleus has a radius shorter than the critical radius, the droplet will not vanish, but will reach a steady-state radius. As the ionic charge increases, the critical radius for droplet growth will decrease and the corresponding steady-state droplet radius will increase. In addition we show that once a critical charge is reached, all droplets will grow regardless of initial radius.