共查询到20条相似文献,搜索用时 15 毫秒
1.
Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide variety of cargo, power cell locomotion, drive cell division and, when combined in large ensembles, allow organisms to move. Motor defects can lead to severe diseases or may even be lethal. Basic principles of motor design and mechanism have now been derived, and an understanding of their complex cellular roles is emerging. 相似文献
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
对无换向器电机和异步机并联组成的协同调速系统进行分析,提出协同调速系统中电机工作特性的计算方法。讨论了并联系统中异步电机负载变化对无换向器电机运行的影响以及协同调速时逆变器的换流问题。给出了实验机组的理论计算值和实验结果。 相似文献
12.
13.
All members of the diverse myosin superfamily have a highly conserved globular motor domain that contains the actin- and nucleotide-binding sites and produces force and movement. The light-chain-binding domain connects the motor domain to a variety of functionally specialized tail domains and amplifies small structural changes in the motor domain through rotation of a lever arm. Myosins move on polarized actin filaments either forwards to the barbed (+) or backwards to the pointed (-) end. Here, we describe the engineering of an artificial backwards-moving myosin from three pre-existing molecular building blocks. These blocks are: a forward-moving class I myosin motor domain, a directional inverter formed by a four-helix bundle segment of human guanylate-binding protein-1 and an artificial lever arm formed by two alpha-actinin repeats. Our results prove that reverse-direction movement of myosins can be achieved simply by rotating the direction of the lever arm 180 degrees. 相似文献
14.
设计了一种新型的由动圈直线电机驱动可用于可凸变椭圆活塞车削的伺服刀架系统,给出了新型刀架机械系统的数学模型及其闭合控制系统的组成,分析了动圈中温升较高的原因,提出了降低动圈铜损、限制温升的措施。 相似文献
15.
Biodiversity: turning up the heat on hotspots 总被引:1,自引:0,他引:1
16.
Cell motility: multiple microtubule motors 总被引:2,自引:0,他引:2
J M Scholey 《Nature》1990,343(6254):118-120
17.
18.
19.
20.
P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The seven P2X receptor subtypes are implicated in physiological processes that include modulation of synaptic transmission, contraction of smooth muscle, secretion of chemical transmitters and regulation of immune responses. Despite the importance of P2X receptors in cellular physiology, the three-dimensional composition of the ATP-binding site, the structural mechanism of ATP-dependent ion channel gating and the architecture of the open ion channel pore are unknown. Here we report the crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of the apo receptor. The agonist-bound structure reveals a previously unseen ATP-binding motif and an open ion channel pore. ATP binding induces cleft closure of the nucleotide-binding pocket, flexing of the lower body β-sheet and a radial expansion of the extracellular vestibule. The structural widening of the extracellular vestibule is directly coupled to the opening of the ion channel pore by way of an iris-like expansion of the transmembrane helices. The structural delineation of the ATP-binding site and the ion channel pore, together with the conformational changes associated with ion channel gating, will stimulate development of new pharmacological agents. 相似文献