Hypothalamic nerve fibres in the pars tuberalis and pia-arachnoid tissue of the cat and their degeneration pattern after a lesion in the hypothalamus

Zusammenfassung Mit der Bielschowsky-Gros-Methode wurden bei Katzen Nervenfasern untersucht, die vom Infundibulum in die Pars tuberalis ziehen. Die Befunde an normalen Tieren und an einer Katze mit einer Hypothalamus-Läsion zeigen, dass eine beachtliche Zahl hypothalamischer Fasern in verschiedene Teile der Pars tuberalis, sowie in das Gewebe der Pia und der Arachnoidea übergehen.Bei der operierten Katze wurde das Degenerationsbild der in den dorsalen Teil der Pars tuberalis ziehenden Hypothalamus-Fasern beschrieben.     

Organization in "barrels" of layer-IV cells of the S1 cortex in the mouse: effects of lesions or deprivation of the mystacial vibrissa]

In newborn mice the mystacial pads of the upper lips were submitted to different destructive or functionally reducing procedures. The effects on the barrels of the somato-sensory cortex were judged in mature animals and classified into 3 categories: 1. the barrels were present and normal; 2. the cortex was devoid of barrel structures; 3. the barrels were disorganized. Only procedures which involved peripheral lesions, and not those which reduced only the functional level, produced effects as deep as absence or disorganization of the barrels.     

Visualization of opiate receptors in the locus coeruleus of rats: high resolution radioautography after administration of a tritiated met-enkephalin analog]

Opiate receptor sites were visualized by high resolution radioautography in the locus coeruleus of the Rat following intraventricular injection of the met-enkephalin analogue FK 33-824 tritiated with a high specific activity (3H-FK). After administration of a tracer dose of 3H-FK, more than 75% of the radioactivity detected in the locus coeruleus is specifically bound to opiate receptor sites. These are distributed both between and inside neuronal perikarya. After administration of 3H-FK at high concentration, electron microscope radioautography shows the presence of specific opiate binding sites at the level of axo-somatic and axo-dendritic synaptic junctions. These synaptic binding sites could correspond to receptor sites for endogenous enkephalins.     

Attempt to induce, in the rat, a hepatitis of cirrhotic origin, using amino steroids: holaphyllaminol or amino 3-beta hydroxy-20-beta pregnene-5]

Holaphyllaminol, or Amino-3 beta-Hydroxy-20-beta Pregnene-5, was administered by gastric tube to male Wistar rats at dose of 50, 100 and 200 mg/kg/24 hr respectively, during 10, 20, 40 and 80 days. This substance provokes hepatic lesions beginning at the periportal region, the characteristics of which are a cholestasis, a canalar proliferation and a fibrosis. The interest of these alterations lies in the fact that they present the same features as certain human chronic hepatitis; their progression, a function of the dose of the toxin and the duration of treatment, may make possible to realisation of a model of experimental chronic hepatitis.