机器学习技术在生物信息挖掘中的方案探讨

后基因时代,探索和解释隐藏在分子生物学数据库中的有用信息是对生物信息学研究人员的巨大挑战!为了解决分子生物学中遇到的这些难题,有效及廉价的方法是非常必要的.机器学习是一个崭新的计算机应用领域,而生物信息学是生物学与计算机科学以及应用数学等学科相互交叉而形成的一门新兴学科.本文分析了机器学习技术的内容,介绍了生物信息学的内涵和新的应用技术,同时探索了机器学习技术对生物信息挖掘应用的途径.这些方法有助于加速生物分子结构预测、基因发现、基因组学和蛋白组学等方面的研究进展.     

机器学习方法及其在生物信息学中的应用

分析了机器学习技术的内容,介绍了生物信息学的内涵和新的应用技术,同时探索了机器学习技术对生物信息挖掘应用的途径.这些方法有助于加速生物分子结构预测、基因发现、基因组学和蛋白组学等方面研究的进展.     

机器学习在生物信息学中的应用

机器学习具有从数据和经验中获取知识的学习能力，能用于从大量生物数据中提取知识的过程。生物信息学是一个融合多门学科的领域，包括分子生物学、计算机科学、物理化学和数学。机器学习算法已成为生物信息学中数据分析算法的主要内容。介绍了典型的机器学习方法以及它们在生物信息学中的应用。     

癌症和癌症治疗中的生物信息学方法

生物信息学是用数理和信息科学的观点、理论和方法，以计算机为工具对生物信息进行获取、处理、存储、分配、分析和解释的一门学科，它是生物学、医药学、计算机科学、物理学和数学等学科的有机结合。本书讲述了在癌症研究中所使用的生物信息学分析技术、方法和实验平台等，向读者展示了如何使用生物信息学方法进行癌症相关的研究，以及作为一个连接基础科学与临床应用的桥梁，生物信息学方法是如何积极地影响癌症患者的治疗的。     

分子生物学技术及其在污染生态学中的应用研究进展

分子生物学技术在污染生态学中的应用日益广泛,本文综述了应用于污染生态学中的各项分子生物学技术,包括电泳分离显示技术、分子标记技术、DNA序列分析和基因工程技术等,并阐述了分子生物学技术在污染环境中生物种群动态分析、生物群落结构多样性、污染环境的监测预警和生物修复等方面的应用,同时提出在今后的污染生态学研究中,要探索多种技术的综合使用.     

生物大分子中的原子等效电荷分布计算

生物大分子的动力学模拟，对理解或探索生物大分子生物学功能的相互关系具有重要的指导意义．而生物大分子动力学模拟中，其分子中原子等效电荷分布的推算或描述，则是模拟过程中的重要方面．本文基于密度泛函理论框架的电负性均衡法和基于分子轨道理论的Qeq方法对生物大分子中原子等效电荷的分布进行概要地模拟和分析；同时对这些方法的生物学领域的应用以及最新研究进展作简要阐述．     

生命科学领域的前沿科学：生物信息学

从生物信息学兴起的历史条件，常用的生物信息数据库，生物信息学的基本分析方法，生物信息学和计算机的关系，生物信息学的主要研究内容等方面介绍了生物信息学，阐述了生物信息学的发展前景和亟待解决的问题。     

基因序列的搜索与相似性比对

生物信息学的基本任务是对各种生物分析序列进行分析,也就是研究新的计算机方法,从大量的序列信息中获取基因结构、功能和进化等知识,并将其存储于基因数据库中.而在序列分析中,将未知序列同基因数据库中已知序列进行相似性比较是一种强有力的研究手段,包括序列的片段测定、拼接,基因的表达分析,以及RNA和蛋白质的结构功能预测.     

甘蓝型油菜(Brassica napus)中一个未知功能蛋白基因的cDNA克隆

随着现代分子生物学的发展,许多物种,特别是拟南芥等模式生物的整个基因组序列以及其中一部分基因的功能已经比较清楚,但仍然存在大量功能未知的基因有待进一步研究,从已知片段出发,利用cDNA末端快速扩增（rapid amplification of cDNA ends,RACE）技术钓取基因全长,并结合生物信息学技术预测蛋白质结构,是研究未知基因功能的一种重要手段．     

组合数学在生物信息学教学中的应用

从试验中获取的生物信息进行储存、检索和分析是生物信息学研究的基本工作,所得的生物信息往往是离散的数据,而组合数学研究的对象就是离散数据,并有成熟的理论体系和组合算法思想,因此可以利用组合算法模型,以计算机为工具研究生物信息数据。本文浅谈组合数学在生物信息学教学中应用,以及在生物信息学专业中开设的重要性。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that