A new synthetic method of coumestan derivatives

Zusammenfassung Die Synthese von 7-Hydroxy-5,6-dimethoxybenzofurano[3,2:3,4]coumarin aus 7,2-Dihydroxy-oder 7-Benzyloxy-2-hydroxy-4,5-dimethoxyisoflavon wird beschrieben.     

The syntheses of axillarin and its related compounds

Zusammenfassung Axillarin (5, 7, 3, 4-Tetrahydroxy-3,6-dimethoxyflavon). 5,3,4-Trihydroxy-3,6,7-trimethoxyflavon und 5,7,3,4-Tetrahydroxy-3,8-dimethoxyflavon wurden synthetisiert.     

Fever produced in rabbits by N6, O2′-dibutyryl adenosine 3′, 5′-cyclic monophosphate

Zusammenfassung Die Injektion von N⁶-2-O-Dibutyryl-adenosin-3 5-monophosphat in den lateralen Hirnventrikel von Kaninchen führt zu einer langanhaltenden Fieberreaktion, was vermuten lässt, dass zyklisches Adenosin-35-monophosphat als weiterer Mediator in der Genese des Fiebers fungiert.     

The synthesis of a natural dinucleoside phosphate derivative with the aid of a purine cyclonucleoside

Zusammenfassung Die Behandlung von 8-5-Anhydro-8-mercapto-2-o-mesylguanosin mit (1,2 Äquivalent) Tributylammonium-uridylat in siedendem DMF lieferte das Dinucleosidphosphat Uridyl-(3-5)-8-mercapto-2-o-mesylguanosin. Weitere Behandlung mit Raney Ni führte zum Uridyl-(3-5)-2-o-mesylguanosin.     

Zur Synthese des Batrachotoxinins: Synthese von 3β-Acetoxy-16β, 20β-dihydroxy-4′-methyl-18-nor-5β, 14β-pregnano[13,14-f]hexahydro-1′,4'-oxazepin-3′-on(20a)

Summary The synthesis of 3-acetoxy-16, 20-dihydroxy-4-methyl-18-nor-5, 14-pregnano[13,14-f]hexahydro-1, 4-oxazepin-3-one (20a) is described.     

Microbiological transformation of biflavone

Summary Incubation of 5,5-7,7-tetramethoxy-8,8-biflavone withAspergillus niger results in the formation of 4,4-dihydroxy-5,5-7,7-tetramethoxy-8,8-biflavan.Part of this work was done at Allahabad University, Chemical Laboratories.     

Synthesis of dinucleoside phosphates by reaction of 5′-chloro-5′-deoxynucleosides with nucleotide anions

Zusammenfassung Uridylyl-(3–5)-adenosin und Uridylyl-(3-5)-ionosin wurden durch Umsetzung eines passenden 5-chloro-5-deoxy-2, 3-O-isopropylidene-Nukleosids mit Uridin-3-phosphat synthetisiert.     

Über das Vorkommen verschieden substituierter Chalkone während der Mikrosporogenese beiTulipa

Summary During the development of anthers inTulipa cv. Apeldoorn the following chalcones were isolated: 2, 3, 4, 4, 6-pentahydroxychalcone as the main component and 2, 4, 4, 6-tetrahydroxy-3-methoxychalcone as well as 2, 4, 4, 6-tetrahydroxychalcone in a very small amount.

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Die Untersuchungen wurden mit Mitteln der Deutschen Forschungsgemeinschaft unterstützt.     

A new chalcone glucoside and cernuoside from the flowers ofAcacia dealbata

Summary A new chalcone glucoside has been isolated from the flowers ofAcacia dealbata and shown to be 4,2,4,6-tetrahydroxy-3-methoxychalcone 2-O--D-glucoside (1) by chemical degradations and spectroscopic methods. Cernuoside (4,6,3,4-tetrahydroxyaurone 4-O--D-glucoside), (2) has also been found in this plant material.Acknowledgments. The author thanks Prof. H. Wagner, Institut für pharmazeutische Arzneimittellehre der Universität München, for a sample of homoeriodictyol, and Prof. J.B. Harborne, University of Reading, for a sample of aureusidin.     

Total synthesis of orellinine,a minor toxic component of the fungusCortinarius orellanus fries

Summary The 3,3,4,4-tetrahydroxy-2,2-bipyridyl-N-oxide has been synthesized by dealkylation of the corresponding tetramethyl derivative. The chemical properties of this compound are identical to those reported for the minor fungal toxin ofCortinarius orellanus, orellinine.This work is part of the Tesi di Laurea of Miss Cinzia Pierucci.     

Polyhydroxylated metabolites oftrans-stilbene in the rat

Zusammenfassung Nach Eingabe vontrans-Stilben bei Ratten wurden die grössten Mengen im Harn als 3,4,4-Trihydroxystilben, 3,4,4-Trihydroxybibenzyl und 3,3, 4,4-Tetrahydroxybibenzyl nachgewiesen. Die Bibenzylderivate werden nachscheinlich nach Ausscheidung in der Galle von Darmbakterien metabolisiert.     

Effect of urochordamines on larval metamorphosis of ascidians

Two pteridine-containing bromophysostigmine alkaloids, urochordamine A and B, which were isolated from ascidians as larval metamorphosis promoters, were converted to more polar compounds, urochordamine A and B, respectively, when left standing in protic solvents. These four compounds promoted larval metamorphosis of the ascidianHalocynthia roretzi in the order A>A>B>B, and induced metamorphosis of the pediveliger larvae of the musselMytilus edulis galloprovincialis.     

Topochemical approach to the structure-activity relation. Retroenantio-Gly5,10-gramicidin S

, . , -Gly^5,10- , Gly^5,10- .     

The effect of cyclic N-2-O-dibutyryl-adenosine-3′, 5′-monophosphate on neuromuscular transmission and concentration of glycogen in the isolated phrenic nerve-diaphragm preparation of the rat

Résumé Le dérivé dibutyrique du 3, 5-AMP cyclique potentialise les contractions du diaphragme provoquées par stimulation électrique indirecte, alors que l'application du 3,5-AMP cyclique n'a pas un tel effet. D'autre part, ce dérivé diminue le taux de glycogène du diaphragme, ce qui n'est pas le cas pour le 3,5-AMP cyclique.     

Antimalarial activity of racemic 3-Epidihydroquinine, 3-Epidihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei

Zusammenfassung Ein Vergleich dieser Resultate mit denjenigen, die wir für (±)-Dihydrochinin und (±)-Dihydrochinidin berichtet haben², bestätigt die Ergebnisse anderer Arbeiten⁴, dass Inversion am C-3 nur eine geringe Abnahme der Aktivität zur Folge hat. Die folgenden Aktivitäten gegenPlasmodium berghei in Mäusen² wurden in abnehmender Ordnung festgestellt: Dihydrochinidin>Dihydrochinin3-Epidihydrochinidin>3-Epidihydrochinin. Die Ersetzung der 6-Methoxygruppe mit einer 6, 7-Methylendioxy- oder 7-Chlorgruppe ist eine wirksame Abwandlung; die 7-Chlorderivate scheinen bisher die wirksamsten Verbindungen sowohl in der 3-Epials auch in dernormalen Serie zu sein².     

The selective esterification of the 5′-hydroxyl of thymidine

Zusammenfassung Ein einfacher Weg zur selektiven Esterbildung mit der 5-Hydroxylgruppe von Thymidin wird beschrieben. Beispiele: Thymidin-5-phosphat, Thymidin-5-sulfat und Thymidin-5-trichloracetat.     

Induction of ingestive responses by cAMP applied into the rat hypothalamus

Riassunto L'applicazione stereotassica di microdosi di dibutirril-adenosin-3 5 monofosfato nell'area ipotalamica laterale zona incerta di ratti sazi causa un netto aumento nell'ingestione di acqua. L'aumento è molto simile a quello causato dalla carbamoilcolina posta nella stessa zona.     

Study of neurosecretory cells ofHelix pomatia by intracellular dye injection

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Changes in the activities of protein kinase modulators in the cerebellum of mice due to ethanol,caffeine, or phenobarbital administration

Summary Decreased activities of both the inhibitory modulator of adenosine 35-monophosphate (cAMP)-dependent protein kinase (A-PK) as well as the stimulatory modulator of guanosine 35-monophosphate (cGMP)-dependent protein kinase (G-PK) from the mouse cerebellum were noted due to the administration of excessive doses of ethanol, caffeine, and phenobarbital for up to 28 days. The dose-dependence of the inhibition of A-PK or the stimulation of G-PK was observed as a function of the amount of protein kinase modulators in the cerebellum of mice receiving different doses of ethanol.Acknowledgments. This work was supported by a grant (RR 08119-06-PK modulator project) from NIH, USA. J.L. Williams, T. Floyd-Jones, C.F. Duggans, D.L. Boone, and S.O. Smith were prebaccalaureate trainees of MBS program. Authors thank Dr J.F. Kuo of Emory University for encouragement in this project.