Polyhydroxylated metabolites oftrans-stilbene in the rat

Zusammenfassung Nach Eingabe vontrans-Stilben bei Ratten wurden die grössten Mengen im Harn als 3,4,4-Trihydroxystilben, 3,4,4-Trihydroxybibenzyl und 3,3, 4,4-Tetrahydroxybibenzyl nachgewiesen. Die Bibenzylderivate werden nachscheinlich nach Ausscheidung in der Galle von Darmbakterien metabolisiert.     

Urinary catecholamine metabolites (vanylmandelic and homovanillic acds) in the rat after subchronic treatment with sodium nitrate or nitrite

Summary Sodium nitrate and nitrite in rat food (5 and 0.5% respectively) result in a decrease of both food intake and growth. These agents induce a specific increase in the urinary excretion of 2 catecholamine metabolites: vanylmandelic and homovanillic acids.This work was supported by D. G. R. S. T. grant No. 80. G. 0908 (Nutrition humaine — Toxicologie alimentaire).     

Urinary kallikrein from normal and hypertensive rats

Résumé L'amoindrissement de l'activité kallikréinique urinaire chez les rats hypertendus (technique deGrollman ¹⁰) est due à une diminution de l'élimination de cet enzyme, puisque la cinétique enzymatique, l'action des inhibiteurs sur l'activité estérasique (sur BAEE) et oxytoxique est égale à celle trouvée chez la kallikréine urinaire des rats normaux.     

Identification of two new metabolites of caffeine in the rat urine

Résumé L'acide 1, 3, 7-triméthyldihydro-urique et la 3, 6, 8-triméthylallantoïne ont été identifiés comme métabolites nouveaux de la cafféine dans l'urine de rat.     

Maternal stress alters monoamine metabolites in fetal and neonatal rat brain

Heat-restraint stress given rats during the last week of gestation significantly altered dopaminergic dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA) and noradrenergic 3-methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG) forebrain-hypothalamic monoamine (MA) metabolites in female offspring. On gestational day 21, HVA and MOPEG were significantly higher and lower, and on postnatal day 1 all were higher. There were virtually no differences in brain MA concentrations in males. Thus MA metabolic concentrations differ in fetal-neonatal forebrain-hypothalamus as a function of sex differences and maternal stress.     

Maternal stress alters monoamine metabolites in fetal and neonatal rat brain

Summary Heat-restraint stress given rats during the last week of gestation significantly altered dopaminergic dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA) and noradrenergic 3-methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG) forebrain-hypothalamic monoamine (MA) metabolites in female offspring. On gestational day 21, HVA and MOPEG were significantly higher and lower, and on postnatal day 1 all were higher. There were virtually no differences in brain MA concentrations in males. Thus MA metabolic concentrations differ in fetal-neonatal forebrain-hypothalamus as a function of sex differences and maternal stress.     

Circadian rhythmycity of some key metabolites in the fasted and fed weanling female rat

Zusammenfassung Bei je 32 Ratten im Hungerzustand und mit normaler Fütterung wurden Tagesschwankungen von Na, K, Protein, Harnstoff, Phosphor und Glukose im Serum gefunden. Die Schwankungen spiegeln zweifellos die Aktivität mehrerer endokriner Sekretionen wider, welche wiederum von der Biologischen Uhr⁸ beeinflusst werden.

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This investigation was supported by U.S.P.H.S. Grant No. HE 06975 from the National Heart Institute.     

ATPase in the normal and dystrophic developing retina of the rat

Riassunto Viene descritto un aumento significativo dell'attività specifica dell'ATPasi (attività/mg proteine) durante lo sviluppo post-natale della retina in ratti normali ed in ratti con retinite pigmentosa ereditaria. Il rapporto tra attività ATPasica in presenza di Mg⁺⁺-Na⁺-K⁺ ed attività ATPasica in presenza di Mg⁺⁺ non varia nella retina normale, mentre esso va incontro ad un precoce declino durante lo sviluppo della retina distrofica. Il significato di questi dati è discusso molto brevemente.     

Urinary excretion of C14-histamine and metabolites in cats after C14-histamine given intravenously,and into the cerebral ventricles

Zusammenfassung In narkotisierte Katzen wurde C¹⁴-Histamin entweder durch Hirnventrikel perfundiert oder intravenös injiziert. Seine Ausscheidung und Metabolite in Urin wurde gleichzeitig bestimmt: Ca. 2% des durch die Hirnventrikel perfundierten C¹⁴-Histamins wurde im Blutstrom resorbiert.     

Increased relative growth rate of normal rat cells in vitro with crocetin

Summary The carotenoid crocetin (earlier found to increase relative growth of Walker 256 tumor cells and their radiosensitivity), is shown to increase the relative growth of normal Sprague-Dawley rat muscle derived cells in vitro, presumably by increasing oxygen transport.     

Regional hematocrit ratio and interstitial fluid volume in the normal rat

Résumé La détermination, dans les tissus, du volume globulaire et plasmatique, ainsi que de l'hématocrite, doit être pratiquée après un temps de mélange approprié et en évitant les erreurs dues à la variation locale de la concentration d'indicateur. Les valeurs normales sont fort différentes pour les divers organes étudiés et ne peuvent pas être calculés à partir des résultats obtenus par la mesure de l'hématocrite ou des volumes plasmatiques et globulaires corporels dans le sang artériel.     

Ammoniacal silver staining of normal and inflamed rat synovial membrane

Summary An ammoniacal silver technique was used to detect changes in histone profiles in normal rats and rats with adjuvant-induced arthritis. Under these conditions histone staining reactions change at times when synovial cells are becoming more metabolically active.Acknowledgments: Supported by Biomedical Research Development Grant No. ISO08RR09016-01 from the National Institutes of Health, by grants to both authors from the Marquette University Committee on Research and by Marquette University School of Dentistry.     

Absence of phosphogluconate pathway activity in normal and in ethanol-intoxicated slices from rat brain

Résumé L'auteur a repris la question de l'existence d'une voie oxydative fonctionnelle directe pour la glucose dans le cerveau adulte et constaté qu'elle ne peut être décelée ni dans des conditions normales ni lors d'une intoxication du sujet par l'étanol.     

Contribution of diffusive pathway in intestinal absorption of glucose in rat under normal feeding condition

Summary Luminal concentration of glucose determined by a specific enzymatic method was about 50 mM after meal in rat jejunum. The diffusive pathway was suggested to have an important role in intestinal absorption of glucose.     

Cellular and subcellular localization of3H-estradiol or its metabolites in the pituitary of the neonatal female rat

Zusammenfassung Bei 2 Tage alten Ratten wurde markiertes Oestradiol-17 injiziert. Im Hypophysenvorderlappen waren weniger als 10% der Zellkerne markiert. Diese Zellen befanden sich vorwiegend in der Peripherie. Im Zwischen- und Hinterlappen fanden sich keine markierten Zellen. Eine Vorbehandlung mit nicht markiertem Oestradiol hemmte die nukleare Aufnahme der Radioaktivität, was beweist, dass diese mit Oestradiol oder dessen Metaboliten verbunden sein muss.     

Isolation of histone proteins from rat normal and tumour blood plasma

Summary Histone proteins were isolated from both normal and tumour rat blood plasma: H1, (H2b+H2a) for normal plasma and H1, H3, (H2b+H2a) and H4 for tumour one.