Cardiac glycogen fractions in the ventricles of fasted and non-fasted,exercised rats

Zusammenfassung Vergleich von Glykogenfraktionen aus Ventrikeln männlicher Albinoratten, die 24 h gefüttert wurden, mit Nichgefütterten. Letztere verbrauchten meistens TCA (ungebundenes Glykogen) nach Bewegung, während gefütterte Ratten sowohl Rest-Glykogen (gebundenes) wie auch TCA Glykogen verbrauchten. Die Glykogenabnahme war im linken Ventrikel nach Bewegung grösser als im rechten.

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This investigation was supported by Public Health Service Research Grant No. HE 06747.     

Lithium effects upon components of activity in rats

Summary When lithium chloride was administered to rats several changes occurred in a number of components of activity, some of which were sex-related. There was a reduction in both ambulatory and rearing activity and in behaviour associated particularly with the mouth and nose. The findings are related to a suggestion that lithium effects on behaviour may be more subtherthan hitherto thought.     

Lithium effects upon components of activity in rats.

When lithium chloride was administered to rats several changes occurred in a number of components of activity, some of which were sex-related. There was a reduction in both ambulatory and rearing activity and in behaviour associated particularly with the mouth and nose. The findings are related to a suggestion that lithium effects on behaviour may be more subtle than hitherto thought.     

Dissociation of vertical and horizontal components of activity in rats treated with lithium chloride

Résumé La chlorure de lithium, administré aux rats. a affaibli leur activité verticale, sans porter atteinte à leur activité horizontale. Ces résultats sont compatibles avec l'hypothèse selon laquelle le lithium affaiblit les réponses des animaux aux stimulations.     

CO-binding pigment (P-450) and other electron transport components in hepatoma bearing rats

Zusammenfassung Basierend auf früheren Eiweissuntersuchungen bezüglich einer endoplasmatisch-retikulären Elektronenstromkette ergibt sich: NADPH-Oxydase und Zytochrom-c-Reduktase sind in der normalen Rattenleber wie in der Hepatoma (Typ 7777) tragenden gleich, während die Ferricyanid-Reduktase und P-450 in der Leber der letzteren herabgesetzt waren.     

Extracellular matrix components in intestinal development

Intestinal morphogenesis and differentiation are dependent on heterotypic cell interactions between embryonic epithelial cells (endoderm) and stromal cells (mesenchyme). Extracellular matrix molecules represent attractive candidates for regulators of these interactions. The structural and functional diversity of the extracellular matrix as intestinal development proceeds is demonstrated by 1) spatio-temporal specific expression of the classically described constituents, 2) the finding of laminin and collagen IV variants, 3) changes in the ratio of individual constituent chains, and 4) a stage-specific regulation of basement membrane molecule production, in particular by glucocorticoids. The orientation/assembly of these extracellular matrix molecules could direct precise cellular functions through interactions via integrin molecules. The involvement of extracellular matrix, and in particular basement membrane molecules in heterotypic cell interactions leading to epithelial cell differentiation, has been highlighted by the use of experimental models such as cocultures, hybrid intestines and antisense approaches. These models allowed us to conclude that a correct elaboration and assembly of the basement membrane, following close contacts between epithelial and fibroblastic cells, is necessary for the expression of differentiation markers such as digestive enzymes.     

Snake venom components and their applications in biomedicine

Snake envenomation is a socio-medical problem of considerable magnitude. About 2.5 million people are bitten by snakes annually, more than 100,000 fatally. However, although bites can be deadly, snake venom is a natural biological resource that contains several components of potential therapeutic value. Venom has been used in the treatment of a variety of pathophysiological conditions in Ayurveda, homeopathy and folk medicine. With the advent of biotechnology, the efficacy of such treatments has been substantiated by purifying components of venom and delineating their therapeutic properties. This review will focus on certain snake venom components and their applications in health and disease. Received 6 July 2006; received after revision 14 August 2006; accepted 28 September 2006     

Urushiol components as mediators in DNA strand scission

Summary Poison oak urushiol, a mixture of 3-alk(en)ylcatechol derivatives was found to mediate DNA strand scission in the presence of oxygen and with copper(II) chloride as a catalyst. The reactionis believed to occur via activated reduced oxygen produced during oxidation of the catechol into itso-quinone derivative.