Inhibition of uridinediphosphate glucuronyltransferase caused by furosemide

Summary The diuretic agent, furosemide, inhibits liver microsomal uridinediphosphate glucuronyltransferase (EC. 2.4.1.17), in monkey and rat. Inhibition is of the non-competitive type.     

Inhibition of uridinediphosphate glucuronyltransferase caused by furosemide

The diuretic agent, furosemide, inhibits liver microsomal uridinediphosphate glucuronyltransferase (EC. 2.4.1.17), in monkey and rat. Inhibition is of the non-competitive type.     

Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids

The inhibitory effect of four flavonoid compounds on virus multiplication and their influence on the intracellular cyclic AMP (cAMP) level were studied in cell cultures. Quercetin and quercitrin reduced the yields of Human (alpha) herpesvirus 1 (HSV-1) and Suid (alpha) herpesvirus 1 (pseudorabies virus), but hesperidin and rutin had no effect. Further, quercetin and quercitrin elevated the intracellular level of cAMP, whereas hesperidin and rutin did not alter the cAMP level. Both antiviral activity and cAMP-enhancing effect were dependent on the concentrations of the flavonoids, and these effects turned out to be parallel. This study suggests that a relation exists between the antiviral effect and the cAMP-enhancing activity of flavonoids.     

Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids

Summary The inhibitory effect of four flavonoid compounds on virus multiplication and their influence on the intracellular cyclic AMP (cAMP) level were studied in cell cultures. Quercetin and quercitrin reduced the yields ofHuman (alpha) herpesvirus 1 (HSV-1) andSuid (alpha) herpesvirus 1 (pseudorabies virus), but hesperidin and rutin had no effect. Further, quercetin and quercitrin elevated the intracellular level of cAMP, whereas hesperidin and rutin did not alter the cAMP level. Both antiviral activity and cAMP-enhancing effect were dependent on the concentrations of the flavonoids, and these effects turned out to be parallel.This study suggests that a relation exists between the antiviral effect and the cAMP-enhancing activity of flavonoids.     

Inhibition of EMC virus reproduction and prevention of cell death by amino acid analogues and puromycin

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Inhibition of the regulatory ability of stomata caused by exhaust gases

Summary It is demonstrated that very low concentrations of exhaust gases from a combustion engine inhibit the regulatory ability of stomata. However, when gas treatment was stopped, plants showed a quick recovery of the ability to close stomata.     

Inhibition of cell division in mammalian cell cultures by hypertonic medium

Résumé L'arrêt de la métaphase se produit dans les cellules de HeLa S-3 au contact d'un milieu de tonicité accrue (>165 mM). L'accumulation optimale intervient à 277 mM lorsque du NaCl a été utilisé pour augmenter l'influence du milieu. Les effets de l'usage d'autres sels et d'autres types de cellules sont décrits. La dilution du milieu à 165 mM donne lieu à un arrêt synchrone du processus de la mitose dans les cellules et assure la conservation d'un bon synchronisme au cours de la division cellulaire suivante.     

Acceleration of crypt cell proliferation by acoustic stimuli

Summary Cell proliferation rates in the bases of the crypts of Lieberkuhn in the jejunum of rat were measured using a stathmokinetic technique. In rats subjected to recurring loud noise cell proliferation was more rapid than in rats not subjected to the noise.     

Mast cell destruction caused by distilled water

Zusammenfassung Intraperitoneal injiziertesaqua destillata, welches Schock hervorruft, führt zu einem starken Mastzellenzerfall. Derselbe bleibt bei osmotischer Wirkung ohne Schock wesentlich geringer.     

The germ cell — oncogenic and embryogenic correlates

Summary This study is based on 100 consecutive germ cell tumors of the gonads, received during a 5-year period. Benign teratomas, with totipotent differentiation are the commonest ovarian germ cell tumors, whereas the nullipotent germinomas from the bulk of the testicular tumors. Differentiation in the rapidly proliferating testicular teratomas, occurs in the form of embryoid bodies and organoid structures. From an analysis of the germ cell tumors it is evident that the ovum confers differentiating functions on the zygote, while the spermatozoon confers functions of organization and proliferation. This difference in the behavior of the 2 germ cells is due to local feedbacks within the cortical and medullary zones of the gonads.Acknowledgments. I wish to thank Dr S. K. Lal, Maulana Azad Medical College, New Delhi, for his valuable suggestions concerning gonadal functions. Reprint requests to B. I., B-72, Pandara Road, New Delhi-110003 (India).     

Template preference of polymerases and its relevance to oncogenic RNA virus replication

Zusammenfassung DNS-Polymerae aus Kalbsthymus (in50%-Glycerin-haltigem Puffer gelöst) zeigt bei Kühlaufbewahrung Alterung mit Änderung ihrer Template-Präferenz von einstrangiger zu doppelstrangiger DNS.

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Supported by U.S. Public Health Service and Damon Runyon Grants.