On the role of antidiuretic hormone in volume natriuresis and polyuria in rats

Zusammenfassung An Ratten wird gezeigt, dass eine ADH-Infusion in niedriger Dosierung die Natriurese unter einer Belastung mit physiologischer NaCl nicht beeinflusst, während das Urinvolumen reduziert wird.

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Acknowledgement. Skilful technical assistance of Mrs.M. Blaková is sincerely appreciated.     

Stimulation of sodium transport by antidiuretic hormone in bullfrog intestine

Summary Antidiuretic hormone (ADH) increased the potential difference (PD) and shortcircuit current (SCC) across the small intestine of the bullfrog. This effect was independent of those produced by amiloride or high calcium but was masked by a theophylline-induced effect. Net active sodium (Na⁺) absorption accounted for the observed electrical changes.This work was supported by Whitehall Foundation, grant No. 78 156 ck-1 DSR No.     

Stimulation of sodium transport by antidiuretic hormone in bullfrog intestine.

Antidiuretic hormone (ADH) increased the potential difference (PD) and shortcircuit current (SCC) across the small intestine of the bullfrog. This effect was independent of those produced by amiloride or high calcium but was masked by a theophylline-induced effect. Net active sodium (Na+) absorption accounted for the observed electrical changes.     

Effect of human serum oxytocinase on the antidiuretic action of lysine vasopressin and oxytocin in the rat

Zusammenfassung Nach i.v. Dauerinfusion von Lysin-Vasopressin oder Oxytocin wird bei der experimentellen Analyse der Wirkung menschlicher Oxytocinase eine Erniedrigung des antidiuretischen Effekts gefunden; diese rührt vom Absinken der Peptidkonzentration sowohl im Blutplasma als auch am Wirkort her.     

Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration

Summary The growth hormone (GH) and prolactin releasing (PRL) activity of [D-Met², Pro⁵]-enkephalinamide (EKNH₂), an opioid peptide analog with higher opiate agonist activity that morphine, was compared in the unanesthetized male rat to those of equimolar doses of morphine upon systemic injection. EKNH₂ proved to be a higher PRL, but not GH, releaser than the opiate alkaloid.     

Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man

Summary Human -atrial natriuretic peptide (h-ANP) makes the urine of dehydrated volunteers hypotonic to plasma despite high circulating concentrations of antidiuretic hormone. Urinary dilution with h-ANP also occurs in subjects receiving indomethacin. Therefore, h-ANP antagonises effects of antidiuretic hormone on distal tubular V₂-receptors in man, probably without involving prostaglandins.     

Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man

Human alpha-atrial natriuretic peptide (h-alpha ANP) makes the urine of dehydrated volunteers hypotonic to plasma despite high circulating concentrations of antidiuretic hormone. Urinary dilution with h-alpha ANP also occurs in subjects receiving indomethacin. Therefore, h-alpha ANP antagonises effects of antidiuretic hormone on distal tubular V2-receptors in man, probably without involving prostaglandins.     

Colchicine dissociates the toad (Bufo arenarum) urinary bladder responses to antidiuretic hormone and to serosal hypertonicity

Resumen Los efectos de la ocitocina y la hipertonía serosa sobre la respuesta hidrosmótica de la vejiga urinaria del sapo pueden ser disociados empleando colchicina, y mas evidentemente cuando el alcaloide es colocado junto con Cu⁺⁺.     

Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat

Acute or chronic injection of RX 77,368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO2) and brown adipose tissue activity in the rat, and decreased weight gain. Other TRH analogues (CG 3509, RGH 2202) and TRH itself also stimulated VO2. These thermogenic actions are probably mediated centrally by stimulation of sympathetic outflow to brown fat.     

Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat

Summary Acute or chronic injection of RX 77368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO₂) and brown adipose tissue activity in the rat, and decreased weight gain Other TRH analogues (CG 3509, RGH 2202) and TRH itself also stimulated VO₂. These thermogenic actions are probably mediated centrally by stimulation of sympathetic outflow to brown fat.     

A depolymerizing effect of the luteinizing hormone and follicle stimulating hormone on the neurotubules of the hypothalamus-hypophysial tract in the rat

Résumé Les neurotubules des fibres nerveuses du tract hypothalamo-hypophysaire du rat sont désorganisées après des traitments in vitro avec l'hormone lutéinisante et l'hormone folliculaire stimulante. Le méchanisme de dépolymérisation est discuté.