Defining disposition concepts: A brief history of the problem

The aim of this paper is twofold. Firstly, I give a brief account of the history of the debate on the problem of defining disposition concepts from its beginning in the late 1920s until today. This account is divided into four parts, corresponding with 2, 3, 4 and 5 of the paper, each of which deals with a major period of the debate. Section 2 reports up to the mid-1950s. Section 3 deals with important contributions to the discussion between 1955 and 1958. However, the progress made around that time was far ahead of the logical theory and techniques which were needed for foundational reasons and for a better understanding of the basic notions. Some logical techniques appropriate for that aim were developed in the late 1960s and early 1970s. Though not uncontroversial, those logical techniques resulted in improvements of the insights gained in the mid-1950s; I shall report on those logical techniques and their application to the problem of defining disposition concepts in Section 4. In the early 1990s, however, the whole tradition of defining disposition concepts in terms of conditionals has been challenged by some strong counter-examples which are treated in Section 5. Finally, the second of the aims of this paper is explored in Section 6, in which I sketch very briefly the current stage of the debate by discussing and evaluating the most recent approaches to the subject.     

Natural diversity: A neo-essentialist misconstrual of homeostatic property cluster theory in natural kind debates

In natural kind debates, Boyd's famous Homeostatic Property Cluster theory (HPC) is often misconstrued in two ways: Not only is it thought to make for a normative standard for natural kinds, but also to require the homeostatic mechanisms underlying nomological property clusters to be uniform. My argument for the illegitimacy of both overgeneralizations, both on systematic as well as exegetical grounds, is based on the misconstrued view's failure to account for functional kinds in science. I illustrate the combination of these two misconstruals with recent entries into the natural kind debate about emotions. Finally, I examine and reject Stich's “Kornblith-Devitt method” as a potential justification of these misconstruals.     

Climate change transformation: A definition and typology to guide decision making in urban environments

Climate change presents a threat to the sustainability of cities and their societies, and must be adequately addressed. Urban environments (cities) are responsible for the creation of a significant amount of greenhouse gas emissions which are the source of climate change. Cities have been increasingly the focus of action to address climate change, yet emissions are not significantly reducing. Additionally, there a lack of integration between adaptation and mitigation. This prevents responses adequate to limit global warming to 1.5^OC, and to be well adapted to anticipated changes. This paper critically analyses existing definitions and typologies of climate change actions. A definition of ‘climate change transformation’ is proposed which includes the integration of adaptation and mitigation goals to enable a new regime in which global warming is limited to 1.5^OC. A new three-part typology: ‘coping, malaction and transformation,’ is presented for categorising climate change actions by the extent to which they integrate adaptation and mitigation, and define a new regime. The typology is accompanied by illustrations to demonstrate the relationship between adaptation and mitigation. The definition, typology and illustration serve to guide effective climate change decision making, and provides principles to guide application in urban environments.     

Climate change transformation: A definition and typology to guide decision making in urban environments

Climate change presents a threat to the sustainability of cities and their societies, and must be adequately addressed. Urban environments (cities) are responsible for the creation of a significant amount of greenhouse gas emissions which are the source of climate change. Cities have been increasingly the focus of action to address climate change, yet emissions are not significantly reducing. Additionally, there a lack of integration between adaptation and mitigation. This prevents responses adequate to limit global warming to 1.5^OC, and to be well adapted to anticipated changes. This paper critically analyses existing definitions and typologies of climate change actions. A definition of ‘climate change transformation’ is proposed which includes the integration of adaptation and mitigation goals to enable a new regime in which global warming is limited to 1.5^OC. A new three-part typology: ‘coping, malaction and transformation,’ is presented for categorising climate change actions by the extent to which they integrate adaptation and mitigation, and define a new regime. The typology is accompanied by illustrations to demonstrate the relationship between adaptation and mitigation. The definition, typology and illustration serve to guide effective climate change decision making, and provides principles to guide application in urban environments.     

Climate change transformation: A definition and typology to guide decision making in urban environments

Climate change presents a threat to the sustainability of cities and their societies, and must be adequately addressed. Urban environments (cities) are responsible for the creation of a significant amount of greenhouse gas emissions which are the source of climate change. Cities have been increasingly the focus of action to address climate change, yet emissions are not significantly reducing. Additionally, there a lack of integration between adaptation and mitigation. This prevents responses adequate to limit global warming to 1.5^OC, and to be well adapted to anticipated changes. This paper critically analyses existing definitions and typologies of climate change actions. A definition of ‘climate change transformation’ is proposed which includes the integration of adaptation and mitigation goals to enable a new regime in which global warming is limited to 1.5^OC. A new three-part typology: ‘coping, malaction and transformation,’ is presented for categorising climate change actions by the extent to which they integrate adaptation and mitigation, and define a new regime. The typology is accompanied by illustrations to demonstrate the relationship between adaptation and mitigation. The definition, typology and illustration serve to guide effective climate change decision making, and provides principles to guide application in urban environments.     

Narrow and broad styles of scientific reasoning: A reply to O. Bueno

In a recent paper, Otávio Bueno (2012) introduced a narrower understanding of Hacking's concept of styles of scientific reasoning. Although its ultimate goal is to serve a pluralist view of science, Bueno's proposal is a thought-provoking attempt at outlining a concept of style that would keep most of the original understanding's heuristic value, while providing some analytical grip on the specific details of particular scientific practices. In this reply, I consider solely this latter more proximate goal. More precisely, I assess whether or not Bueno's narrower understanding of styles could provide historians and philosophers of science with a workable unit to investigate particular transformations in scientific practices. While the author's proposal is certainly interesting overall, the usefulness of the unit it describes may be compromised by three shortcomings: 1° the extent to which the unit is meant to be narrower is indeterminate; 2° it does not improve much on the analytical capabilities of Hacking's concept; and 3° like Hacking's concept it is rather powerless to capture the dynamical character of particular scientific practices.     

Regulation of cell adhesion by PP2A and SV40 small tumor antigen: An important link to cell transformation

The serine/threonine protein phosphatase 2A (PP2A) represents a large family of highly conserved heterotrimeric enzymes. Their critical importance in cell homeostasis is underlined by the fact that they are targets of natural toxins like the tumor promoter okadaic acid, and of simian virus 40 small tumor antigen (SV40 small t), a viral protein known to promote cell transformation. Furthermore, mutated or lower expression levels of PP2A subunits have been found in certain cancers. One major known event in PP2A-dependent cell transformation is the alteration of key signaling pathways that control cell growth and survival. In this review, we focus on how PP2A enzymes also affect cell adhesion and cytoskeletal dynamics, the disruption of which is linked to loss of cell polarity, increased cell motility and invasiveness. We also examine how those various pathways participate in the transforming activity of SV40 small t. Received 29 June 2006; received after revision 3 August 2006; accepted 20 September 2006