核受体LXRα靶基因研究进展

核受体的研究近几年已有飞速的发展。LXRα(Liver X Receptor α)是一种与脂类代谢有关的核受体。研究发现LXRa的靶基因具有调节脂类的吸收、运输、转化和生物合成的功能，此外，LXRα在糖类的代谢等方面也有重要的调控作用。研究结果表明LXRα与动脉粥样硬化的发生有非常密切的关系。目前利用LXRα为靶标进行抗动脉粥样硬化药物筛选已经成为一个重要的研究方法。     

水稻光温敏核不育调控基因及作用机理研究进展

我国两系法杂交水稻理论与技术体系研究已取得重大突破,进入大规模生产应用实践阶段。本文综述了水稻光温敏核不育系的类型、育性转换特性,以及近五年来对其不育基因的定位克隆和育性调控机理研究方面的新进展,并对研究中存在的问题进行了讨论。     

基因编辑技术研究进展与挑战

基因编辑技术是指对基因进行修饰而获得新的特征或功能的技术,当前研究最多的是始于2012年的第三代CRISPR/Cas9基因编辑系统及相关技术,其他近几年新兴起来的基因编辑系统包括单碱基基因编辑技术、引导编辑技术、RNA编辑技术等.基因编辑技术近年来蓬勃发展,技术本身得以不断改进,新成果加速涌现.基因编辑系统已在疾病治疗...     

比格犬黑皮质素受体3基因291位点突变与体重性状相关性的分析

分析比格犬MC3R基因突变与体重性状的关系。抽取112只比格犬血液,记录体重数据,然后提取DNA;采用PCR-RFLP技术对MC3R基因G291A位点进行分析,并克隆测序。测序结果表明,291位点表现为G、A二个等位基因和GG、GA及AA三种基因型;统计分析结果显示AA型犬与GG型犬体重比较差异显著（P〈0．05）。犬MC3R基因突变可致体重增加,可作为犬体重标记的候选基因。     

核电技术现状与研究进展

对世界核电发展最新现状进行了概述，综述世界上第三代和第四代核电技术研究进展，最后介绍了核聚变发电技术的前景。     

研究开发的全球化

继贸易全球化、生产全球化之后,研究开发全球化已经成为经济一体化的重要趋势。本文分析了研究开发全球化的背景、动机及主要方式,并介绍了日本、韩国在美国的研究开发及国外企业在华研究开发的情况。在此基础上,对我国企业“走出去”提出了一些建议。     

国内外环境材料最新研究进展

介绍了环境材料的概念，对近期国内外在环境材料理论和应用研究领域取得的进展进行了综述，指出了未来环境材料研究的发展方向。     

Catching the WAVE: The Weight-Adjusting Account of Values and Evidence

It is commonly argued that values “fill the logical gap” of underdetermination of theory by evidence, namely, values affect our choice between two or more theories that fit the same evidence. The underdetermination model, however, does not exhaust the roles values play in evidential reasoning. I introduce WAVE – a novel account of the logical relations between values and evidence. WAVE states that values influence evidential reasoning by adjusting evidential weights. I argue that the weight-adjusting role of values is distinct from their underdetermination gap-filling role. Values adjust weights in three ways. First, values affect our trust in the testimony of others. Second, values influence the evidential thresholds required for justified epistemic judgments. Third, values influence the relative weight of a certain type of evidence within a body of multimodal discordant evidence. WAVE explains, from an epistemic perspective, rather than psychological, how smokers, for example, can find the same evidence about the dangers of smoking less persuasive than non-smokers. WAVE allows for a wider effect of values on our accepted scientific theories and beliefs than the effect for which the underdetermination model allows alone; therefore, science studies scholars must consider WAVE in their research and analysis of evidential case studies.     

The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis

The RAG1 and RAG2 proteins play a crucial role in V(D)J recombination by cooperating to make specific double-stranded DNA breaks at a pair of recombination signal sequences (RSSs). However, the exact function they perform has heretofore remained elusive. Using a combination of sensitive methods of sequence analysis, we show here that the active core region of the RAG2 protein, confined to the first three quarters of its sequence, is in fact composed of a six-fold repeat of a 50-residue motif which is related to the kelch/mipp motif. This motif, which forms a four-stranded twisted antiparallel β sheet, is arranged in a circular formation like blades of a propeller or turbine. Given the known properties of the β-propeller fold in mediating protein-protein interactions, it is proposed that this six-laded propeller structure of the RAG2 active core would play a crucial role in the tight complex formed by the RAG1 and RAG2 proteins and RSSs. Moreover, the presence of a plant homeodomain finger-like motif in the last quarter of the RAG2 sequence suggests a potential interaction of this domain with chromatin components. Received 6 June 1998; accepted 9 June 1998