A new ester glucoside from the bark ofTecomella undulata

Zusammenfassung Isolierung und Strukturaufklärung eines neuen Esterglukosides aus der Rinde vonTecomella undulata.     

Leukocyte mobilization from the guinea pig spleen by muscarinic cholinergic stimulation

Important interactions between the immune system and the nervous and endocrine systems have become increasingly accepted. The present results demonstrate that the cholinergic agonist carbacholine greatly increased the number of granulocytes and lymphocytes in the splenic venous blood, but not arterial blood, shortly after administration to guinea pigs. The effect was largely blocked by pretreatment with atropine. In contrast, animals treated with indomethacin had a decreased number of leukocytes in both splenic venous and arterial blood. A decrease in relative splenic weight due to carbacholine treatment was also blocked by atropine. However, cholinergic leukocyte mobilization, or that previously observed after adrenergic stimulation, may not be caused by capsule contraction since it is not accompanied by mobilization of erythrocytes. Furthermore, indomethacin, which potentiates the response of splenic smooth muscle to adrenergic stimuli, blocked the effect of noradrenaline (NA) on leukocyte mobilization.     

Leukocyte mobilization from the guinea pig spleen by muscarinic cholinergic stimulation

Important interactions between the immune system and the nervous and endocrine systems have become increasingly accepted. The present results demonstrate that the cholinergic agonist carbacholine greatly increased the number of granulocytes and lymphocytes in the splenic venous blood, but not arterial blood, shortly after administration to guinea pigs. The effect was largely blocked by pretreatment with atropine. In contrast, animals treated with indomethacin had a decreased number of leukocytes in both splenic venous and arterial blood. A decrease in relative splenic weight due to carbacholine treatment was also blocked by atropine. However, cholinergic leukocyte mobilization, or that previously observed after adrenergic stimulation, may not be caused by capsule contraction since it is not accompanied by mobilization of erythrocytes. Furthermore, indomethacin, which potentiates the response of splenic smooth muscle to adrenergic stimuli, blocked the effect of noradrenaline (NA) on leukocyte mobilization.     

Histochemical demonstration for the release of norepinephrine from the sympathetic nerves in the cat spleen

Résumé Le développment de fluorescence diffuse provoquée dans les cellules lisses, les trabécules et le tissue élastique par la stimulation des nerfs spléniques du chat pendant l'occlusion, est tenu pour évidence directe de la libération de noradrénaline provenant de nerfs sympathiques.     

Molecular hybridization of RNA from chicken spleen cells after immunization

Zusammenfassung Es wird mit neuer Technik gezeigt, dass nach Immunisierung von Hühnern in der Milz neue Ribonukleinsäuren erscheinen.     

Leucine aminopeptase in the spleen

Zusammenfassung Leucinaminopeptidase wird histochemisch in der Milz von Mäusen und Ratten untersucht. Eine besonders ausgeprägte Reaktion zeigte sich in der Zentralarterienwandung und in den umgebenden Reticulumzellen der weissen Pulpa. Im Bereich der roten Pulpa verhalten sich nur die Inseln positiv, während eine extramedulläre Hämatopoese vorkommt.     

Somatostatin reduces the release of colony-stimulating activity (CSA) from PHA-activated mouse spleen lymphocytes

Summary PHA-activated lymphocytes release colony-stimulating activity (CSA) for macrophage-granulocyte precursor cells (colony forming units, CFU_C) in the culture medium. Somatostatin, known to interfer with ribosomal protein synthesis, was demonstrated to reduce the release of CSA from PHA-treated mouse spleen lymphocytes.The technical assistance of Ulrike Wallner and Paulette Bais is thankfully acknowledged.     

Changes in antigenicity of rats spleen cells nuclei resulting from total-body X-irradiation

Résumé Les études immunologiques de l'ADN et l'ADNP, extraits des cellules normales de la rate des rats, ont demontré que ces constituants cellulaires ont au moins la propriété d'haptène.     

Somatostatin reduces the release of colony-stimulating activity (CSA) from PHA-activated mouse spleen lymphocytes.

PHA-activated lymphocytes release colony-stimulating activity (CSA) for macrophage-granulocyte precursor cells (colony forming units, CFUc) in the culture medium. Somatostatin, known to interfer with ribosomal protein synthesis, was demonstrated to reduce the release of CSA from PHA-treated mouse spleen lymphocytes.