Metabolic effects of neopyrithiamine and the aneurin contents in the tissues of the rat

Riassunto Ratti trattati con neopiritiamina presentano un contenuto particolarmente basso di aneurina nel tessuto nervoso (cervello) e non rispondono alla somministrazione di glucoso (per os) con aumento di Q.R. e di produzione calorica come, invece, fanno i controlli e i ratti carenzati mediante la dieta (3–4 settimane).     

In vitro effects of different rat tissues on radioiodinated 4-iodoantipyrine

Résumé On a étudié l'action de differents tissus du rat sur la 4-iodoantipyrine radioiodée. On a observé une activité déiodante seulement avec le tissu hépatique.     

Fever and survival in the rat. Metabolic versus temperature response

Summary In infected rats, survival was directly proportional to the metabolic cost of fever (O₂%°C) during its rising phase and inversely proportional to the height of fever. It is suggested that some febrile, metabolic response may be beneficial, while the rise in temperature may be harmful for the host animal.I thank Dr W. Mannheim from the Institute of Hygiene for kindly furnishing the cultures ofS. enteritidis. This work was supported by the Schwerpunktprogramm Temperaturregulation und-adaptation of the DFG.     

Metabolic effects of thyroxine in infant rats

Zusammenfassung Die Behandlung 5 oder 8 Tage alter Ratten mit Thyroxin- oder TSH-Injektionen verursachte eine signifikante Stimulierung im Sauerstoffverbrauch und in der Sukzinodehydrogenase-Aktivität im Leber-, Muskel- und Gehirngewebe. Dies zeigt, dass die Inaktivität der Schilddrüse in metabolischer Kontrolle schon innerhalb von 8 Tagen nach der Geburt aufgehoben wird, wenn genügend TSH vorhanden ist.

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Supported by National Research Council for Sciences and by the University of Turku through grants to one of the authors (R.T.). The aid of MissHelka Julku is gratefully acknowledged.     

Association of mastopoiesis with haemopoietic tissues in the neonatal rat

Summary Mast cells in the newborn rat occur in haemopoietic foci of liver and spleen, but disappear from those foci as extramedullary haemopoiesis ceases during the initial postnatal month. At the same time, mast cells increasingly populate bone marrow and connective tissues of heart, lung, stomach and portal tract of liver.J. L. D. acknowledges Scholarships from the National Health and Medical Research Council of Australia while working on this project for the degree of B. Sc. (Med.), the University of New South Wales, and subsequently from the National Heart Foundation of Australia.     

Developmental and ageing changes in aminopeptidase activities in selected tissues of the rat

Aminopeptidase activities, assayed as arylamidase activities, were investigated in selected tissues of 1, 6, 12 and 24-month-old rats. The enzyme activities were found to have a heterogeneous distribution and age-related changes were observed. The highest levels of soluble arginyl-aminopeptidase activity were detected in brain homogenate at all the studied ages, whereas membrane-bound activity presented the highest levels in brain and kidney in the four ages tested. Aspartyl-aminopeptidase activity was detected mainly in the particulate fraction of kidney at all four ages. In 1, 6 and 12-month-old animals, soluble aspartyl-aminopeptidase activity was also higher in the kidney than in the rest of the tissues, whereas in the group of 2-year-old rats, the highest levels were found in both kidney and liver. Age-related changes were observed in all the studied tissues and for all the assayed enzymatic activities. In general, the maximal levels were detected in both the youngest and the oldest animals, and the minimal ones in 6 and 12-month-old rats. However, in the adrenals, the soluble and membrane-bound arginyl-aminopeptidase activity was higher in 6-month and 2-year-old rats than in 1-month and 12-month-old rats. These changes may reflect the functional status of the susceptible endogenous substrates of aminopeptidases.     

Metabolic restoration in rat liver after partial hepatectomy

Zusammenfassung Es zeigt sich während des frühen Regenerationsstadiums bei der teilweise hepatektomierten Rattenleber, dass ein Anstieg im Galaktose-Metabolismus mit gleichzeitiger Abnahme seiner Hemmung durch Ethanol einhergeht. Nach vollständiger Geweberegeneration kehrt der normale Metabolismus zurück.

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I wish to thank ProfessorJ. H. Quastel for providing me with the facilities and for his encouragement during my work at McGill University, Montreal (Canada).     

Anomeric compositions of D-glucose in tissues and blood of rat

Summary The anomeric compositions of D-glucose in the liver, kidney, heart, blood and plasma of rat were determined by our method for the assay of D-glucose anomers and the percentages of the -anomer were found to be 61.8, 61.0, 62.4, 62.7 and 62.9, respectively.     

Anomeric compositions of D-glucose in tissues and blood of rat

The anomeric compositions of D-glucose in the liver, kidney, heart, blood and plasma of rat were determined by our methods for the assay of D-glucose anomers and the percentages of the beta-anomer were found to be 61.8, 61.0, 62.4, 62.7 and 62.9, respectively.     

Sex related fibrinolytic activity in rat tissues

Histochemical study of many organs of male and female adult Wistar rats of the same age showed no difference in fibrinolytic activity (plasminogen activator activity) between the sexes.     

Sex related fibrinolytic activity in rat tissues

Summary Histochemical study of many organs of male and female adult Wistar rats of the same age showed no difference in fibrinolytic activity (plasminogen activator activity) between the sexes.     

Comparative ontogenesis of gamma-glutamyl transpeptidase in rat tissues

Summary In rats, placental gamma glutamyl transpeptidase (GGTP) specific activity declined linearly during the last third of gestation. In contrast, the kidney enzyme activity progressively increased 15-fold. In the gut, peak activity was reached at mid-lactation (age 12 days). Hepatic GGTP levels were maximal during the foetal stage. Brain GGTP was negligible at birth and attained its highest specific activity at weaning.This work was supported in part by USPHS NIH SO8 RR-09128-03.     

Converting enzyme content of different tissues of the rat

Résumé On a dosé l'enzyme de conversion dans différents tissus du rat au moyen d'une méthode chimique mesurant la libération d'histidyl-leucine à partir du substrat synthétique Z-phe-his-leu. Le poumon contient au moins 8 fois plus d'enzyme que tous les autres tissus étudiés. Il en contient notamment plus de 100 fois plus que le foie.     

Observations upon the mast cells of rat foetal tissues

Résumé Dans les études physiologiques récentes, il est dit que l'histamine foetale se montre plusieurs jours avant l'apparition des mastocytes dans les tissus foetaux. Le présent travail démontre que les mastocytes apparaissent plus tôt et sont plus répandus qu'on ne le supposait. Ces constatations confirment d'anciennes observations apparemment oubliées.     

Age- and sex-related differences in the content of prothymosin alpha in rat tissues.

Differences in the tissue content of prothymosin alpha during the early postnatal development of male and female rats are reported. Thymus and spleen have been found to contain significantly higher amounts of prothymosin alpha in the newborn and prepubertal animals, as compared to adults, whereas liver has been found to contain low levels of prothymosin alpha throughout development. These findings indicate a functional association of prothymosin alpha with the proliferating lymphoid tissues of the young rat.     

Distribution of polyamine oxidase activity in rat tissues and subcellular fractions

The activity of polyamine oxidase (PAO) in rat tissues, and its subcellular distribution, were assayed using a simple polarographic method. The highest PAO activity was measured in the liver and the lowest in the skeletal muscle. In liver, kidney and uterus the highest specific PAO activity was found in the light mitochondrial fraction. PAO was not found in the microsomal fraction except in the kidney.