共查询到20条相似文献,搜索用时 31 毫秒
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In 1914, the physics discipline had reached a very similar stage of development in Australia and Japan. A generation later the paths of development had considerably diverged. A systematic comparison of the evolution of physics in the two countries during these years identifies factors—political, economic and cultural—that led to this divergence, but it also uncovers a number of underlying parallels. 相似文献
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T. Nagatsu T. Kato Y. Numata K. Ikuta M. Sano I. Nagatsu T. Takeuchi M. Matsuzaki H. Umezawa 《Cellular and molecular life sciences : CMLS》1977,33(5):581-583
Summary Serum dopamine--hydroxylase activity in spontaneously hypertensive rats and Wistar-Kyoto rats had a positive correlation with dopamine--hydroxylase and tyrosine hydroxylase activities in mesenteric vessels, vas deferens, and adrenal glands at 14–16 weeks of age, a negative correlation with dopamine--hydroxylase activity in locus coeruleus at 3 weeks and 14–16 weeks of age, and a positive correlation with tyrosine hydroxylase activity only at 3 weeks of age, but not at 14–16 weeks of age. 相似文献
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Summary Over three years, theAdh and -Gpdh loci have been studied in two cellar populations ofDrosophila melanogaster and in two field populations which were each near to one of the cellars. Analyses of gene frequencies indicate that the divergence among subpopulations is greater in theAdh locus than in the -Gpdh locus. Selection for or againstAdh
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allele acting on theIn(2L)t inversion influences of the -Gpdh alleles. This phenomenon may contribute to explain the maintenance of theAdh and -Gpdh polymorphism and of theIn(2L)t inversion. 相似文献
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Peroxisomes are single-membrane-bound organelles present in virtually all eukaryotic cells. They are involved in numerous
metabolic processes, both catabolic and anabolic, including β-oxidation of very long chain fatty acids, metabolism of hydrogen
peroxide, plasmalogen biosynthesis and bile acid synthesis. In several genetic diseases, there is either isolated deficiency
of a specific peroxisomal protein (single-protein deficiencies) or a defect in the formation of the organelle with loss of
multiple peroxisomal functions (peroxisome biogenesis disorders). X-linked adrenoleukodystrophy is an example of the former,
and the Zellweger spectrum of the latter. Peroxisome biogenesis disorders are inherited in an autosomal recessive manner and
result from mutations in any of at least 12 PEX genes that encode peroxins. This article reviews the peroxisomal system, the clinical, biochemical and molecular aspects
of peroxisomal disorders, and discusses recent scientific advances in the understanding of peroxisome biogenesis.
Received 16 October 2001; received after revision 2 January 2002; accepted 3 January 2002 相似文献
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This paper examines whether the disaggregation of consumer sentiment data into its sub‐components improves the real‐time capacity to forecast GDP and consumption. A Bayesian error correction approach augmented with the consumer sentiment index and permutations of the consumer sentiment sub‐indices is used to evaluate forecasting power. The forecasts are benchmarked against both composite forecasts and forecasts from standard error correction models. Using Australian data, we find that consumer sentiment data increase the accuracy of GDP and consumption forecasts, with certain components of consumer sentiment consistently providing better forecasts than aggregate consumer sentiment data. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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The correct repair of double-strand breaks (DSBs) is essential for the genomic integrity of a cell, as inappropriate repair
can lead to chromosomal rearrangements such as translocations. In many hematologic cancers and sarcomas, translocations are
the etiological factor in tumorigenesis, resulting in either the deregulation of a proto-oncogene or the expression of a fusion
protein with transforming properties. Mammalian cells are able to repair DSBs by pathways involving homologous recombination
and nonhomologous end-joining. The analysis of translocation breakpoints in a number of cancers and the development of model
translocation systems are beginning to shed light on specific DSB repair pathway(s) responsible for the improper repair of
broken chromosomes.
Received 19 June 2001; received after revision 6 September 2001; accepted 11 September 2001 相似文献
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K. V. Nageswara Rao P. L. Narasimha Rao 《Cellular and molecular life sciences : CMLS》1961,17(5):213-214
Zusammenfassung Die Isolierung, Charakterisierung und antibiotischen Eigenschaften von-Guttiferin (I), C33H38O8 (Smp. 113–115°), aus den Samenhülsen und vom nahe verwandten-Guttiferin (II), C29H36O6 oder C33–34H38–40O8 (Smp. 86–91°) (möglicherweise identisch mit-Gambogasäure), aus Gummigutt, dem harzigen Sekret vonGarcinia morella, wurden beschrieben und ihre Verwandtschaft zu Morellin und Moreollin, den beiden bekannten Pigmenten der Samenhülsen, dargelegt. Für I wurde eine Partialstruktur vorgeschlagen. Die Bildung derselben komplexen bromhaltigen Säure vom Smp. 199 bis 200° unter der Einwirkung von Natriumhypobromit auf I und II spricht ferner für deren nahe strukturelle Verwandtschaft. 相似文献
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Serglycin is a proteoglycan found in hematopoietic cells and endothelial cells. It has important functions related to formation
of several types of storage granules. In connective tissue mast cells the covalently attached glycosaminoglycan is heparin,
whereas mucosal mast cells and activated macrophages contain oversulfated chondroitin sulfate (type E). In mast cells, serglycin
interact with histamine, chymase, tryptase and carboxypeptidase, in neutrophils with elastase, in cytotoxic T cells with granzyme
B, in endothelial cells with tissue-type plasminogen activator and in macrophages with tumor necrosis factor-α. Serglycin
is important for the retention of key inflammatory mediators inside storage granules and secretory vesicles. Serglycin can
further modulate the activities of partner molecules in different ways after secretion from activated immune cells, through
protection, transport, activation and interactions with substrates or target cells. Serglycin is a proteoglycan with important
roles in inflammatory reactions.
Received 2 October 2007; received after revision 7 November 2007; accepted 12 November 2007 相似文献
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Sjöblom B Salmazo A Djinović-Carugo K 《Cellular and molecular life sciences : CMLS》2008,65(17):2688-2701
Alpha-actinin is a cytoskeletal actin-binding protein and a member of the spectrin superfamily, which comprises spectrin, dystrophin and their homologues and isoforms. It forms an anti-parallel rod-shaped dimer with one actin-binding domain at each end of the rod and bundles actin filaments in multiple cell-type and cytoskeleton frameworks. In non-muscle cells, alpha-actinin is found along the actin filaments and in adhesion sites. In striated, cardiac and smooth muscle cells, it is localized at the Z-disk and analogous dense bodies, where it forms a lattice-like structure and stabilizes the muscle contractile apparatus. Besides binding to actin filaments alpha-actinin associates with a number of cytoskeletal and signaling molecules, cytoplasmic domains of transmembrane receptors and ion channels, rendering it important structural and regulatory roles in cytoskeleton organization and muscle contraction. This review reports on the current knowledge on structure and regulation of alpha-actinin. 相似文献
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A. G. Terzian R. R. Safrasbekian R. S. Sukasian G. T. Tatevosian 《Cellular and molecular life sciences : CMLS》1961,17(11):493-494
Résumé L'-méthyltryptamine et le 5-méthoxy dérivé ont été synthétisés en utilisant une variante de la méthode d'Abramovitch etShapiro.Des expériencesin vitro ont montré que ces deux amines ne subissent pas de désamination par la monoaminoxydase du cerveau des rats blancs. La 5-méthoxy--methyltryptamine injectée aux souris blanches en dose de 10 mg/kg semble accroître l'activité de la monoaminoxydase du cerveau. 相似文献
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Konstantin Knoblich Hong-Xing Wang Chandan Sharma Anne L. Fletcher Shannon J. Turley Martin E. Hemler 《Cellular and molecular life sciences : CMLS》2014,71(7):1305-1314
Ablation of tetraspanin protein TSPAN12 from human MDA-MB-231 cells significantly decreased primary tumor xenograft growth, while increasing tumor apoptosis. Furthermore, TSPAN12 removal markedly enhanced tumor-endothelial interactions and increased metastasis to mouse lungs. TSPAN12 removal from human MDA-MB-231 cells also caused diminished association between FZD4 (a key canonical Wnt pathway receptor) and its co-receptor LRP5. The result likely explains substantially enhanced proteosomal degradation of β-catenin, a key effecter of canonical Wnt signaling. Consistent with disrupted canonical Wnt signaling, TSPAN12 ablation altered expression of LRP5, Naked 1 and 2, DVL2, DVL3, Axin 1, and GSKβ3 proteins. TSPAN12 ablation also altered expression of several genes regulated by β-catenin (e.g. CCNA1, CCNE2, WISP1, ID4, SFN, ME1) that may help to explain altered tumor growth and metastasis. In conclusion, these results provide the first evidence for TSPAN12 playing a role in supporting primary tumor growth and suppressing metastasis. TSPAN12 appears to function by stabilizing FZD4–LRP5 association, in support of canonical Wnt-pathway signaling, leading to enhanced β-catenin expression and function. 相似文献
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《Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics》2009,40(4):374-382
In this paper, we discuss various aspects of Heisenberg's thought on hidden variables in the period 1927–1935. We also compare Heisenberg's approach to others current at the time, specifically that embodied by von Neumann's impossibility proof, but also views expressed mainly in correspondence by Pauli and by Schrödinger. We shall base ourselves mostly on published and unpublished materials that are known but little-studied, among others Heisenberg's own draft response to the EPR paper. Our aim will be not only to clarify Heisenberg's thought on the hidden-variables question, but in part also to clarify how this question was understood more generally at the time. 相似文献