共查询到20条相似文献,搜索用时 15 毫秒
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Summary Liver ferritin synthesis was inhibited by 22.3% in rats treated with alcohol (2 g/kg) for 45 days. This inhibition was prevented by simultaneous administration (5 mg/kg) of propylthiouracil during the last 15 days. There was no significant effect on liver ferritin concentration. 相似文献
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T. Kato T. Nagatsu T. Shiio S. Sakakibara 《Cellular and molecular life sciences : CMLS》1979,35(3):409-411
Summary Serum X-prolyl dipeptidyl-aminopeptidase activity which had been shown to be depressed in cancer patients was clearly reduced in mice with Ehrlich carcinoma and Sarcoma 180, and slightly reduced in mice with methylcholanthrene-induced sarcomas. The reduced enzyme activity was completely reversed during tumour regression of sarcoma 180 by administration of lentinan, which causes regression of sarcoma 180. 相似文献
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Serum X-prolyl dipeptidyl-aminopeptidase activity which had been shown to be depressed in cancer patients was clearly reduced in mice with Ehrlich carcinoma and Sarcoma 180, and slightly reduced in mice with methylcholanthrene-induced sarcomas. The reduced enzyme activity was completely reversed during tumour regression of sarcoma 180 by administration of lentinan, which causes regression of sarcoma 180. 相似文献
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Zusammenfassung Es wird die cancerostatische Wirkung des 6-Azauracilribosids auf die subkutane Form des Ehrlich-Aszites-Tumors beschrieben und festgestellt, dass 6-Azauracilribosid ungefähr 6mal wirksamer ist als 6-Azauracil. 相似文献
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Specific removal of DNA antibody with an immunoadsorbent 总被引:3,自引:0,他引:3
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K. F. Cheng C. S. Yip H. W. Yeung Y. C. Kong 《Cellular and molecular life sciences : CMLS》1979,35(5):571-572
Summary Leonurine (1) is the uterotonic principle ofLeonurus artemisia. We have developed a simple, high-yield synthetic procedure of1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 11 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro.Acknowledgment. This work was partly supported by World Health Organization, Geneva, Switzerland. 相似文献
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Promotion of antibody formation by prostaglandin 总被引:1,自引:0,他引:1
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Pinho SS Seruca R Gärtner F Yamaguchi Y Gu J Taniguchi N Reis CA 《Cellular and molecular life sciences : CMLS》2011,68(6):1011-1020
Several mechanisms have been proposed to explain the E-cadherin dysfunction in cancer, including genetic and epigenetic alterations.
Nevertheless, a significant number of human carcinomas have been seen that show E-cadherin dysfunction that cannot be explained
at the genetic/epigenetic level. A substantial body of evidence has appeared recently that supports the view that other mechanisms
operating at the post-translational level may also affect E-cadherin function. The present review addresses molecular aspects
related to E-cadherin N-glycosylation and evidence is presented showing that the modification of N-linked glycans on E-cadherin can affect the adhesive function of this adhesion molecule. The role of glycosyltransferases
involved in the remodeling of N-glycans on E-cadherin, including N-acetylglucosaminyltransferase III (GnT-III), N-acetylglucosaminyltransferase V (GnT-V), and the α1,6 fucosyltransferase (FUT8) enzyme, is also discussed. Finally, this
review discusses an alternative functional regulatory mechanism for E-cadherin operating at the post-translational level, N-glycosylation, that may underlie the E-cadherin dysfunction in some carcinomas. 相似文献
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J. Šterzl 《Cellular and molecular life sciences : CMLS》1960,16(11):518-519
Zusammenfassung Eine Anzahl Kaninchen wurde durch humanes Serumalbumin (HSA) sensibilisiert. Wurde bei ihnen durch eine weitere Dosis desselben Antigens (HSA) eine Hypersensitivitätsreaktion hervorgerufen, so wurde die Antikörperbildung gegen ein anderes gleichzeitig eingeführtes Antigen (Ovalbumin-OA) stimuliert. 相似文献
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Summary 4 distinct electronic inputs can be identified in amphibian motoneurons perfused with calcium-free solution containing manganese. The differential effect of 4-aminopyridine on different electrotonic junctions may reflect the peculiarities of molecular architecture of potassium channels in different electrically excitable presynaptic membranes.We thank Prof. D. R. Curtis, of National University Canberra, for the gift of 4-aminopyridine. 相似文献
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Leonurine (1) is the uterotonic principle of Leonurus artemisia. We have developed a simple, high-yield synthetic procedure of 1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1:1 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro. 相似文献
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A Dazord D Gallet J M Saez 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(14):1309-1312
ACTH stimulates the incorporation of 14C-leucine into proteins of adrenal tumor cells in culture. This stimulation though about 20% over controls is statistically significant. Cyclic AMP did not reproduce the stimulation observed with ACTH. 相似文献
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K. Wiesner E. W. K. Jay C. Demerson T. Kanno J. Křepinský Lizzie Poon T. Y. R. Tsai A. Vilím C. S. Wu 《Cellular and molecular life sciences : CMLS》1970,26(9):1030-1033
Zusammenfassung Die stereoselektive Totalsynthese eines Delphininabbauproduktes wird beschrieben. Dieses Produkt, das 5 Ringe und 5 Substituenten besitzt, ist von Delphinin aus leicht zugänglich und kann deshalb als Relais-Verbindung für die Totalsynthese dieses Alkaloids dienen.
Presented at a seminar at the Organic Chemistry Laboratory, ETH, Zurich, Switzerland on June 24, 1969. 相似文献
Presented at a seminar at the Organic Chemistry Laboratory, ETH, Zurich, Switzerland on June 24, 1969. 相似文献
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4 distinct electronic inputs can be identified in amphibian motoneurons perfused with calcium-free solution containing manganese. The differential effect of 4-aminopyridine on different electronic junctions may reflect the peculiarities of molecular architecture of potassium channels in different electrically excitable presynaptic membranes. 相似文献
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Ceelen L Haesebrouck F Vanhaecke T Rogiers V Vinken M 《Cellular and molecular life sciences : CMLS》2011,68(18):3047-3064
Inherent to their pivotal tasks in the maintenance of cellular homeostasis, gap junctions, connexin hemichannels, and pannexin
hemichannels are frequently involved in the dysregulation of this critical balance. The present paper specifically focuses
on their roles in bacterial infection and disease. In particular, the reported biological outcome of clinically important
bacteria including Escherichia coli, Shigella flexneri, Yersinia enterocolitica, Helicobacter pylori, Bordetella pertussis, Aggregatibacter actinomycetemcomitans, Pseudomonas aeruginosa, Citrobacter rodentium, Clostridium species, Streptococcus pneumoniae, and Staphylococcus aureus and their toxic products on connexin- and pannexin-related signaling in host cells is reviewed. Particular attention is paid
to the underlying molecular mechanisms of these effects as well as to the actual biological relevance of these findings. 相似文献