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1.
Summary Approximately 100 times more illumination is required to produce pigment dispersion in the melanophores of eyestalkless fiddler crabs (Uca pugilator) than in the melanophores of intact crabs. The pigment in melanophores of isolated legs will normally disperse in response to irradiation, but this response is inhibited by cytochalasin B.This investigation was supported by a Faculty Research Grant from Western Kentucky University toT. P. Coohill and by Grant No. GB-27497 toM. Fingerman from the National Science Foundation.  相似文献   

2.
Summary An N-glucuronide metabolite of carbamazepine was identified in the bile of the isolated perfused rat liver by means of permethylation, gas chromatography and mass spectrometry.This research was supported by grants from the National Institutes of Health (Nos. N01-NS-5-2328, AM-17665) and the James Whitcomb Riley Memorial Association (No. 74-15) and a grant from the Epilepsy, Foundation of America.  相似文献   

3.
Summary Mast cells in the newborn rat occur in haemopoietic foci of liver and spleen, but disappear from those foci as extramedullary haemopoiesis ceases during the initial postnatal month. At the same time, mast cells increasingly populate bone marrow and connective tissues of heart, lung, stomach and portal tract of liver.J. L. D. acknowledges Scholarships from the National Health and Medical Research Council of Australia while working on this project for the degree of B. Sc. (Med.), the University of New South Wales, and subsequently from the National Heart Foundation of Australia.  相似文献   

4.
Phaeomelanic pigments from a human melanoma   总被引:3,自引:0,他引:3  
Summary The pigments in melanomas from 2 patients were studied with regard to solubility and chemical composition. Melanoma pigment from a patient with red-blonde hair was alkali-soluble and contained 9 or 10% sulfur and was thus of phaeomelanic type. Melanoma pigment from a patient with red-brown hair was insoluble in 0.2N NaOH. Its sulfur content was 6%. This pigment was eumelanic with regard to solubility characteristics but the sulfur content was higher than previously observed for eumelanin.Supported by grants from the Swedish Cancer Society (No. 626-B75-04XA), the Swedish Medical Research Council (No. B76-04X-00056-12), and the Walter, Ellen, and Lennart Hesselman Foundation for Scientific Research. ProfessorProta was a visiting scientist of the Swedish Cancer Society (No. 626-B75-04U).  相似文献   

5.
M Sano  A Ishii 《Experientia》1979,35(4):472-473
The schistosomal and malarial pigments were distinguishable before and after extraction from the host liver. Presence of iron in both pigments was ascertained by the elemental X-ray analysis. Histochemically, however, schistosomal pigment was similar to that of malarial pigment.  相似文献   

6.
Summary The schistosomal and malarial pigments were distinguishable before and after extraction from the host liver. Presence of iron in both pigments was ascertained by the elemental X-ray analysis. Histochemically, however, schistosomal pigment was similar to that of malarial pigment.  相似文献   

7.
The renal handling of unconjugated bilirubin in the dark and during light exposure was analyzed using an isolated rat kidney preparation. The parameters tested were pigment disappearance from the perfusion medium, pigment uptake by tissue, and its renal clearance. The results indicated that despite the fact that pigment disappearance from the medium was similar for both forms of pigment, the extraction ratio was higher for irradiated pigment than for pigment in the dark. When renal clearance of pigment was plotted vs pigment uptake of tissue, the results indicated that irradiated pigment may be more efficiently removed by the kidney. In addition, data on the rate of secretion of p-aminohippurate suggested that both pigment forms shared a common site for secretion.  相似文献   

8.
After i.v. administration to rats of polysaccharide-protein complex, isolated from Candida albicans, a decrease of cardiac output was observed from 20 sec to 240 min postinjection, followed by a recovery at 360 min. Concomitantly the regional blood flow was maintained in heart and lungs, moderately decreased in intestine, liver and adrenals and markedly reduced in skin, muscle, spleen and kidney.  相似文献   

9.
Summary The renal handling of unconjugated bilirubin in the dark and during light exposure was analyzed using an isolated rat kidney preparation. The parameters tested were pigment disappearance from the perfusion medium, pigment uptake by tissue, and its renal clearance. The results indicated that despite the fact that pigment disappearance from the medium was similar for both forms of pigment, the extraction ratio was higher for irradiated pigment than for pigment in the dark. When renal clearance of pigment was plotted vs pigment uptake of tissue, the results indicated that irradiated pigment may be more efficiently removed by the kidney. In addition, data on the rate of secretion of p-aminohippurate suggested that both pigment forms shared a common site for secretion.13 August 1986Acknowledgments. This work was supported by grants from Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), República Argentina. The valuable technical assistance of J. Pellegrino and E. Luque is gratefully acknowledged. We are also indebted to Dr S. Bravlavsky (Max-Planck Institut für Strahlenchemie, D-4330 Mülheim a. d. Ruhr, FRG) for stimulating discussion, and to Mr B. Leguizamón for secretarial assistance.  相似文献   

10.
Summary After i.v. administration to rats of polysaccharide-protein complex, isolated fromCandida albicans, a decrease of cardiac output was observed from 20 sec to 240 min postinjection, followed by a recovery at 360 min. Concomitantly the regional blood flow was maintained in heart and lungs, moderately decreased in intestine, liver and adrenals and markedly reduced in skin, muscle, spleen and kidney.  相似文献   

11.
Summary Trypsin causes an activation of serine sulfhydrase in the liver extracts from intact animals, but inhibits enzyme activity in the liver of ethionine treated rats. Trypsin also decreases an elevation of serine sulfhydrase activity caused by S-adenosylmethionine.This work was supported by the Serbian Medical Research Foundation.  相似文献   

12.
Summary Concentration-response curves for the chronotropic and inotropic effects of isoprenaline, in the absence and presence of propranolol, were obtained on heart atria isolated from normo- or dysthyroid rats. Hyperthyroidism increased the chronotropic potency and efficacy of the -adrenergic agonist. The results are compatible with the view that thyroid hormone increases the density of functional -adrenoceptors in cardiac pacemaker tissue.This study was supported by the Swiss National Science Foundation grant No. 3.374.-0.78. We thank Dr Bachmann from the Central Laboratory of the University Hospital Bern for the estimation of plasma thyroxine levels.  相似文献   

13.
Summary [14C]Orotic acid was rapidly distributed in blood after, both i.p. and s.c. injection but was not completely absorbed from the peritoneal cavity until 20 min after injection. S.c. injection should be an acceptable alternative to i.p. injection although the incorporation into the liver acid soluble- and RNA-fractions was somewhat delayed after the s.c. injection.This work was supported by grants from the Carl Trygger Foundation and the Foundation of Director Albert Påhlsson.  相似文献   

14.
Summary An antimicrobial blue pigment, which is identical with a tetrapyrrole from a bacterium, was isolated from the bryozoanBugula dentata.  相似文献   

15.
Summary In this report we demonstrate the immunocytochemical localization of serotonin in endothelial cells of rat coronary vessels and a significant increase in the release of serotonin into the perfusate of Langendorff rat heart preparations during hypoxia. It is suggested that serotonin, localized in endothelial cells, is released during hypoxia and could provide part of a pathophysiological mechanism for vasodilatation to protect the heart from damage due to hypoxia.This research was supported by the British Heart Foundation and the excellent technical assistance of Jon Bokor is gratefully acknowledged.  相似文献   

16.
Summary Ethanol was administered i.p. to adult roosters during hormonally induced vitellogenin synthesis. At moderate doses, ethanol had no influence on the synthesis of vitellogenin nor did it cause alterations in the size distribution of liver polyribosomes.This was supported in part by a grant from the Foundation for Alcohol Studies, Finland.  相似文献   

17.
Summary Wood frogs survive extracellular freezing at moderate subzero temperatures (–4°C) for at least 11 days. Freezing survival is aided by the accumulation of high concentrations of glucose as a cryoprotectant in blood and tissues. Glucose production was accompanied by a rapid decline in liver, but not muscle, glycogen levels suggesting that liver is the organ controlling cryoprotectant synthesis.Acknowledgments. This study was supported by grants to L.M.G. from the Kroc Foundation (Santa Ynez, California) and from the National Institute of Dental Research (Grant No. DE-03987). The authors wish to thank K. Yorko, M. Shakin, J. Finan and Mrs N. Manivannan for their technical and secretarial assistance.Acknowledgments. I thank Dr J. Ballantyne, Dr F. Schueler and I. McMurray for help with frog collections and Dr. W. Schmid, Dr J. Bogart and Dr F. Cook for helpful discussions. Supported by an N.S.E.R.C. operating grant and by a grant from the Atkinson Charitable Foundation.  相似文献   

18.
Summary Localization of galactocerebroside in kidney, liver, and lung of hamster was studied by the immunoperoxidase method using an affinity-purified specific antibody. Epithelial cells of the following anatomical sites were labelled with the antibody: distal tubuli, ascending limbs of Henle's loops, and collecting tubuli in kidney; periportal bile ducts and hepatic parenchyma in liver; bronchioli and alveoli in lung. The existence of galactocerebroside in these 3 organs was also confirmed by chemical analysis.This study was supported in part by grants from the Ministry of Education, Science and Culture of Japan, a Research Grant for Intractable Diseases from the Ministry of Health and Welfare of Japan, and a grant from the Mitsubishi Foundation.  相似文献   

19.
Summary A net reabsorption of fluid was observed in isolated ferret trachea under control conditions. Cholinergic stimulation resulted in net secretion of fluid while atropine blocked this response without any effect on the basal process of fluid reabsorption.Supported by research grants from the Cystic Fibrosis Foundation and the University of Florida (GML) and by a Pediatric Pulmonary Center award (A 2018) from the Division of Maternal and Child Health of the Department of Health and Human Services and Whitehall Foundation grant (No. 78-156 ck-1).  相似文献   

20.
Summary Evidence from light and electron microscopic studies indicates that differentiation of myocardial cells in moth embryos begins at 6 days post-oviposition and is completed on eclosion. Fibrillogenesis, and development of cytoplasmic organelles and membranes are described. The heart is fully differentiated and functional at eclosion.Acknowledgments. This work was supported by the New Hampshire Heart Association and the National Science Foundation.  相似文献   

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