Combined action of rous sarcoma virus and chemical carcinogen in rats

Zusammenfassung Zwei bis drei Wochen alte Ratten wurden einer kombinierten Einwirkung von 7,12-Dimethylbenz(a)anthrazen und Rous-Sarkoma-Virus ausgesetzt. Das chemische Karzinogen wurde i.m., das Virus dagegen i.v., zugeführt. Viele der Ratten entwickelten 3–4 Monate später Fibrosakomen und Zysten ohne topographische Beziehung zu dem lokal deponierten Karzinogen. In einem Fibrosarkom der Leber konnte der Rous-Sarkoma-Virus nachgewiesen werden. Virus allein war nicht imstande, Tumore und Zysten in gleichaltrigen Ratten hervorzurufen. Das chemische Karzinogen erzeugte Tumore nur am Platze der i.m. Injektion.

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Supported by grant No. CA 06415 from N.I.H. and by the Swedish Cancer Society.     

Inhibitory action of trypsin and trypsin-inhibitors on experimental inflammation in rats

Zusammenfassung Die entzündungshemmende Wirkung von einigen in der Natur vorkommenden Trypsin-Inhibitoren wurde an Ratten mit experimenteller Kaolin-Arthritis nachgewiesen. Die entzündungshemmende Wirkung von Trypsin könnte demzufolge auf eine durch die Applikation von Trypsin bedingte, reaktive Mobilisierung endogener Protease-Inhibitoren zurückgeführt werden.     

Combined action of nickel sulfate and x-irradiation on human lymphoblastoid leukemic cells]

In a first experiment, cells were cultured in media supplemented by nickel sulphate, irradiated in same media and cultured in same media after irradiation. In a second experiment, cells were cultured during 18 hrs. in media supplemented by nickel sulphate, and then cells were washed and cultured in normal media where they were irradiated. The nickel sulphate toxicity appears as a creasing function of the nickel sulphate concentration and the nickel sulphate action endurance. The nickel sulphate toxic effect is amplified by X-Rays. This amplification is a time function that depends on the X-Ray dose, nickel sulphate concentration and period of time from the outset of culture to the irradiation. The nickel sulphate toxic effect appears faster when nickel works after X-Rays.     

Immunodepressive activity of adriamycin in experimental infection of the mouse withNippostrongylus brasiliensis

Riassunto È stata messa in evidenza l'azione immunodepressiva dell'adriamicina dell'infezione del topo conNippostrongylus brasiliensis. L'antibiotico prolunga il periodo di permanenza dei parassiti nell'ospite, mentre non modifica la fase invasiva della parassitosi.     

Decrease in stimulation and allogeneic response following experimental infection of mice with human adenovirus 5]

15 days after experimental infection with human adenovirus 5, C57 Bl/6 murine spleen cells were found to have altered in vitro properties. Proliferative response to phytohemagglutinine was slightly increased while the allogeneic response was decreased and the capability to stimulate allogeneic cells was significantly diminished. The degree of expression of surface antigens responsible for allogeneic stimulation is influenced by many regulatory factors, still poorly defined; alteration of some factors of antigenicity may result, directly or indirectly, from certain viral infections.