Increased vascular permeability in the primary cutaneous allograft response in the rat

Résumé La réaction cutanée de l'immunité de transplantation contre une greffe allogénique est accompagnée d'une forte mais courte augmentation de la perméabilité vasculaire. La réponse vasculaire apparait rapidement et cela avant les effets macroscopique ou histologiques de l'immunité de transplantation.     

Kinetics of increased vascular permeability induced in rat skin by serotonin

Résumé Les auteurs ont étudié la cinétique du passage des complexes protein-colorant à travers les capillaires cutanés dont la perméabilité a été augmentée par l'injection préalable de serotonin dans la peau. Les résultats obtenus ont permis d'établir les lois qui règlent cette cinétique et le rôle des recepteurs adrénergic dans le phenomen inflammatoire.     

Increased vascular permeability induced in synovialis of the rat by histamine,serotonin and bradykinin

Résumé La perméabilité vasculaire de la membrane synoviale du rat est augmentée par l'histamine, la sérotonine et la bradykinine. Dans cette réaction la sérotonine est plus active que l'histamine et la bradykinine.

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L.P.B. is supported by a Medical Postgraduate Research Scholarship from the National Health and Medical Research Council of Australia.

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We are indebted to Associate ProfessorJ. Garcia-Lémé, University of São Paulo, Brazil, for advice.     

Changes of mucopolysaccharides in the epiphyseal plates of mice following neonatal thymectomy

Zusammenfassung Es wurde eine Präponderanz der neutralen Mukopolysaccharide in der Epiphysealplatte der neonatal thymektomierten Mäuse beobachtet und das Phänomen diskutiert.     

Effect of parathyroidectomy on the fasting-refeeding response in the rat colon

Following fasting and refeeding, the colonic epithelium of the rat exhibits a marked hyperplasia. This response is of a similar magnitude but of a longer duration to that observed in mice. This response is not affected by reducing serum calcium levels to those reported to alter normal tissue proliferation in vivo.     

Effect of parathyroidectomy on the fasting-refeeding response in the rat colon

Summary Following fasting and refeeding, the colonic epithelium of the rat exhibits a marked hyperplasia. This response is of a similar magnitude but of a longer duration to that observed in mice. This response is not affected by reducing serum calcium levels to those reported to alter normal tissue proliferation in vivo.Supported in part by HRSF, grant T-90, and by grants No. 1-PO2-CA10438 and No. 5-TO10-CA05224 from the National Cancer Institute, DHEW.The authors wish to thank Andrew M. Ruland for performing the serum calcium assays and George Miller of Zivic-Miller Laboratories.     

Changes in placental permeability to corticosterone and estradiol-17beta toward the end of gestation in the rat

Radioactivity in the fetal plasma 1 h after maternal injection of 14C-4-corticosterone or 14C-4-estradiol-17 beta on day 21 of gestation was markedly higher than that 1 h after injection on day 22. Radioactivity in the maternal plasma was not different on these 2 days. The results suggest that the placental permeability to steroids from the mother to the fetus declines toward the end of gestation in the rat.     

Time courses and refractoriness of enhanced vascular permeability induced by histamine,serotonin and bradykinin in synovialis of the rat

Summary Enhanced vascular permeability induced in synovialis of the rat by histamine and serotonin lasts 5–15 min and that induced by bradykinin less than 5 min. Synovialis of the rat becomes refractory to the permeability effects of repeated doses of each of these substances in the hour following initial application.This work was carried out while L.P.B. was supported by a Medical Postgraduate Scholarship from the National Health and Medical Research Council of Australia.     

Continuous quantitative recording of changes in vascular permeability

Zusammenfassung Es wird die Anwendung radioaktiven Phosphanilsäure-Rinderserum-Albumins zur kontinuierlichen Messung von Änderungen der Gefässwandpermeabilität beschrieben.

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This work was supported by a grant and Fellowship (to A.B.) from the Asthma Foundation of New South Wales and a grant from the United States Public Health Service (Grant No. HE 08513-02).     

Bromocryptine treatment and puberty attainment in the female rat

Summary The influence of bromocryptine treatment on the timing of vaginal patency and 1st oestrus in female rats was studied. No significant influence of bromocryptine on these parameters was noted, and it is concluded that suppression of prolactin secretion has no effect on puberty attainment.Acknowledgment. We thank Professor E. Flückiger and Dr H. Friedli, Pharmaceutical Division, Sandoz Ltd, Basle, Switzerland, for the donation of bromocryptine mesylate.     

Autoradiographic localization of radioactivity in female rat neocortex after injection of tritiated estradiol

Zusammenfassung Durch autoradiographische Untersuchung wurde die Einlagerung von Radioaktivität in ein begrenztes Gebiet des Neocortex der Rattenweibchen nach einmaliger Verabreichung von³H-Östradiol im Alter von 5 bis 50 Tagen nachgewiesen. Die reduzierten Silberkörner zeigen eine vorwiegend perinukleare Akkumulation, was für die Zellen der östrogen-Zielgewebe typisch ist.     

Changes in the protein kinase C activity or rat sternomastoid muscle during development and after denervation

Summary The relationship between the activity of protein kinase C (PKC) and muscle innervation was explored in the rat sternomastoid muscle (SM) from day 18 of gestation (E18) to adult age. Between E18 and birth, PKC activity rose 5-fold, and during the day after birth, diminished to a level characteristic of the mature muscle. The rise chiefly occurred in the neural part of the muscle, in both the membrane and the cytosol fractions. Between E18 and day 5 after birth, the ratios of membrane to cytosol PKC activity rose from 0.5 to 10 and 3 respectively in the neural and aneural parts of the muscle. Denervation of adult SM reduced PKC activity by half in the membrane fraction of the neural part but did not significantly change it in the membrane or cytosol fractions of the aneural parts. These results suggest that innervation plays an important part in determining the level of PKC activity in muscle.     

Changes in the protein kinase C activity or rat sternomastoid muscle during development and after denervation

The relationship between the activity of protein kinase C (PKC) and muscle innervation was explored in the rat sternomastoid muscle (SM) from day 18 of gestation (E18) to adult age. Between E18 and birth, PKC activity rose 5-fold, and during the day after birth, diminished to a level characteristic of the mature muscle. The rise chiefly occurred in the neural part of the muscle, in both the membrane and the cytosol fractions. Between E18 and day 5 after birth, the ratios of membrane to cytosol PKC activity rose from 0.5 to 10 and 3 respectively in the neural and aneural parts of the muscle. Denervation of adult SM reduced PKC activity by half in the membrane fraction of the neural part but did not significantly change it in the membrane or cytosol fractions of the aneural parts. These results suggest that innervation plays an important part in determining the level of PKC activity in muscle.     

Changes in microsomal lipids of rat liver after chronic carbon tetrachloride intoxication

Riassunto Un prolungato trattamento con tetracloruro di carbonio, tale da indurre una grave cirrosi epatica, determina una diminuzione degli acidi grassi più insaturi (acido arachidonico ed acido docosaexenoico) dei fosfolipidi dei microsomi di fegato di ratto. L'ipotesi che tale diminuzione sia dovuta ad una parziale distruzione di questi acidi grassi attraverso un processo di perossidazione lipidica indotto dal CCl₄, è avvalorata dalla presenza, nei lipidi microsomiali, di una banda di assorbimento caratteristica dei «dieni coniugati».