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Inhibition of JNK activation through NF-kappaB target genes. 总被引:26,自引:0,他引:26
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Induction of proto-oncogene JUN/AP-1 by serum and TPA 总被引:116,自引:0,他引:116
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Nuclear factor of activated T cells contains Fos and Jun. 总被引:42,自引:0,他引:42
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Bone and haematopoietic defects in mice lacking c-fos. 总被引:26,自引:0,他引:26
Z Q Wang C Ovitt A E Grigoriadis U M?hle-Steinlein U Rüther E F Wagner 《Nature》1992,360(6406):741-745
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Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. 总被引:30,自引:0,他引:30
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Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage 总被引:55,自引:0,他引:55
J Saklatvala 《Nature》1986,322(6079):547-549
During inflammatory reactions, activated leukocytes are thought to produce a variety of small proteins (cytokines) that influence the behaviour of other cells (including other leukocytes). Of these substances, which include the interleukins, interferons and tumour necrosis factors (TNFs), interleukin-1 (IL-1) has been considered potentially a most important inflammatory mediator because of its wide range of effects. In vivo it is pyrogenic and promotes the acute phase response; in vitro it activates lymphocytes and stimulates resorption of cartilage and bone. Cartilage resorption is a major feature of inflammatory diseases such as rheumatoid arthritis, and IL-1 is the only cytokine hitherto known to promote it. TNFs are characterized by their effects on tumours and cytotoxicity to transformed cells, but share some actions with IL-1. I report here that recombinant human TNF alpha stimulates resorption and inhibits synthesis of proteoglycan in explants of cartilage. Its action is similar to and additive with IL-1, and it is a second macrophage-derived cytokine whose production in rheumatoid arthritis, or inflammation generally, could contribute to tissue destruction. 相似文献
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Stimulatory effect of splicing factors on transcriptional elongation. 总被引:28,自引:0,他引:28