共查询到20条相似文献,搜索用时 15 毫秒
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Defective rRNA synthesis in human leukaemic blast cells? 总被引:1,自引:0,他引:1
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Detection of human leukaemia associated antigens in leukaemic serum and normal embryos 总被引:4,自引:0,他引:4
R Harris D Viza R Todd J Phillips R Sugar R F Jennison G Marriott M H Gleeson 《Nature》1971,233(5321):556-557
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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells 总被引:111,自引:0,他引:111
An emerging concept in the field of cancer biology is that a rare population of 'tumour stem cells' exists among the heterogeneous group of cells that constitute a tumour. This concept, best described with human leukaemia, indicates that stem cell function (whether normal or neoplastic) might be defined by a common set of critical genes. Here we show that the Polycomb group gene Bmi-1 has a key role in regulating the proliferative activity of normal stem and progenitor cells. Most importantly, we provide evidence that the proliferative potential of leukaemic stem and progenitor cells lacking Bmi-1 is compromised because they eventually undergo proliferation arrest and show signs of differentiation and apoptosis, leading to transplant failure of the leukaemia. Complementation studies showed that Bmi-1 completely rescues these proliferative defects. These studies therefore indicate that Bmi-1 has an essential role in regulating the proliferative activity of both normal and leukaemic stem cells. 相似文献
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I antigen in leukaemic patients 总被引:1,自引:0,他引:1
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Nuclear blebs in human leukaemic cells 总被引:1,自引:0,他引:1
N G McDuffie 《Nature》1967,214(5095):1341-1342
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